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Advances in studies on anti-oxidant mechanism of curcumin based on signal transduction pathway / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2373-2380, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-853443
RESUMO
Curcumin is one of the polyphenolic compounds, which is the biological active ingredient of Curcuma longa. Studies indicate a beneficial role of curcumin in terms of anti-oxidant, anti-tumourgenic, and anti-inflammatory properties. And H-atom transfer is a preferred anti-oxidant mechanism of curcumin. Curcumin activates the Nrf2-ARE, NF-κB, NADPH oxidase/ROS, Notch, AMPK/eNOS, and MAPK signal transduction pathways, induces or inhibits signaling molecules and functional gene, modulates the protein expression, increases anti-oxidant enzyme activities, and counteracts oxidative stress.