RESUMO
Lung cancer is the malignant tumor with the highest incidence and mortality in China, and is prone to brain metastasis in the process of disease development, which seriously affects the quality of life and survival of patients. The treatment methods for brain metastasis of lung cancer include surgery, chemotherapy, whole brain radiotherapy, stereotactic radiosurgery, molecular targeted therapy, immunotherapy, anti-angiogenesis therapy, etc. It's one of the research hotspots to choose reasonable and effective treatment schemes for different patients. This paper reviews the research progress in the treatment of brain metastasis from lung cancer, to provide reference for selecting more reasonable clinical treatment for the patients.
RESUMO
Non-small cell lung cancer ( NSCLC) is the most common histological type and accounts for approximately 80%-85%of lung cancers , which can be classified into lung adenocarcinoma , squamous cell carcinomas , and so on.With the coming era of precise treatment, NSCLC is further divided into treatable oncogenic alterations negative-and positive-NSCLC.For patients without treatable oncogenic alterations , platinum-based chemotherapy remains the cornerstone of the treatment , and antiangiogenesis therapy al-so plays an important role in the subsequent treatment .For those with treatable oncogenic alterations , in addition to standard first gener-ation EGFR-TKIs and ALK-TKIs, second and third generation targeted drugs have been investigated in first line or post -resistance treat-ment.The application of immune checkpoint inhibitors has become a new trend of lung cancer treatment .Our review summarizes recent advances in chemotherapy , antiangiogenesis therapy ,target therapy , and immunotherapyof NSCLC .