Clinical Observation on Navel Application of Jianpi Hewei Adhesive Plaster Combined with Oral Use of Modified Sini Hewei Anshen Decoction for the Treatment of Diabetic Gastroparesis Accompanied by Anxiety in Type 2 Diabetes / 广州中医药大学学报

Objective To evaluate the clinical efficacy of navel application of Jianpi Hewei Adhesive Plaster combined with oral use of modified Sini Hewei Anshen Decoction in treating diabetic gastroparesis(DGP)accompanied by anxiety of liver-stomach disharmony type in type 2 diabetes patients.Methods One hundred patients with DGP accompanied by anxiety of liver-stomach disharmony type were randomly divided into a treatment group and a control group,with 50 patients in each group.The control group was given oral use of Mosapride Citrate Tablets orally,and the treatment group was given navel application of Jianpi Hewei Adhesive Plaster combined with oral use of modified Sini Hewei Anshen Decoction.The course of treatment for the two groups covered 4 weeks.The two groups were observed in the changes of the traditional Chinese medicine(TCM)syndrome scores,Gastroparesis Cardinal Symptom Index(GCSI)scores,Hamilton Anxiety Scale(HAMA)scores,gastric emptying time,and levels of fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),plasma motilin(MOT),gastrin(GAS),and serum tumor necrosis factor alpha(TNF-α)and interleukin 6(IL-6)before and after the treatment.After treatment,the clinical efficacy and safety of the two groups were evaluated.Results(1)During the trial,4 patients in the treatment group and 3 patients in the control group fell off,and eventually a total of 93 patients were included for the efficacy statistics,including 46 patients in the treatment group and 47 patients in the control group.(2)After 4 weeks of treatment,the total effective rate of the treatment group was 95.65%(44/46)and that of the control group was 76.60%(36/47).The intergroup comparison(tested by chi-square test)showed that the therapeutic effect of the treatment group was significantly superior to that of the control group(P＜0.01).(3)After treatment,the TCM syndrome scores(including epigastric and abdominal congestion,depression or irritability,and poor appetite)and GCSI scores in the two groups were decreased compared with those before treatment(P＜0.05)and the gastric emptying time was shortened compared with that before treatment(P＜0.05),and the effect of the treatment group on decreasing TCM syndrome scores and GCSI scores and on shortening the gastric emptying time were significantly superior to that of the control group(P＜0.01).(4)After treatment,the plasma MOT and GAS levels of the two groups were increased compared with those before treatment(P＜0.05),and the increase in the treatment group was significantly superior to that in the control group(P＜0.01).(5)After treatment,the levels of glucose metabolism indicators of FBG,2hPG,and HbA1c in the two groups were decreased compared with those before treatment(P＜0.05),but the differences of all glucose metabolism indicators between the two groups after treatment were not statistically significant(P＞0.05).(6)After treatment,the serum TNF-α and IL-6 levels in the two groups were decreased compared with those before treatment(P＜0.05),and the decrease in the treatment group was significantly superior to that in the control group(P＜0.05).(7)After treatment,the total HAMA scores and the scores of mental anxiety factor and somatic anxiety factor of HAMA in the two groups were decreased compared with those before treatment(P＜0.05),and the effect on lowering the scores in the treatment group was significantly superior to that in the control group(P＜0.05).(8)During the treatment period,no significant adverse reactions occurred in the two groups of patients,which has high safety.Conclusion Navel application of Jianpi Hewei Adhesive Plaster combined with oral use of modified Sini Hewei Anshen Decoction exerts certain efficacy in treating DGP accompanied by anxiety of liver-stomach disharmony type.The therapy is effective on relieving clinical symptoms,enhancing gastric motility,inhibiting inflammatory response,and improving anxiety emotion and the quality of life of the patients.

Guanxin Danshen Dripping Pills Improve Quality of Life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study / 中国结合医学杂志

OBJECTIVE@#To assess the efficacy and safety of Guanxin Danshen Dripping Pills (GXDS) in the treatment of depression or anxiety in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).@*METHODS@#From September 2017 to June 2019, 200 CHD patients after PCI with depression and anxiety were included and randomly divided into GXDS (100 cases) and placebo control groups (100 cases) by block randomization and a random number table. Patients in the GXDS and control groups were given GXDS and placebo, respectively, 0.4 g each time, 3 times daily for 12 weeks. The primary outcomes were scores of Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Scale (GAD-7) and the Seattle Angina Pectoris Scale (SAQ). The secondary outcomes included 12 Health Survey Summary Form (SF-12) scores and the first onset time and incidence of major adverse cardiovascular events (MACEs). Other indices including blood pressure, blood lipids, microcirculation and inflammatory-related indices, etc. were monitored at baseline, week 4, and week 12.@*RESULTS@#In the full analysis set (200 cases), after treatment, the PHQ-9 and GAD-7 scores in the GXDS group were considerably lower than those in the control group (P<0.05). Compared with the baseline, the total PHQ-9 scores of the experimental and control groups decreased by 3.97 and 1.18, respectively. The corrected mean difference between the two groups was -2.78 (95% CI: -3.47, -2.10; P<0.001). The total GAD-7 score in the GXDS group decreased by 3.48% compared with the baseline level, while that of the placebo group decreased by 1.13%. The corrected mean difference between the two groups was -2.35 (95% CI: -2.95, -1.76; P<0.001). The degree of improvement in SAQ score, SF-12 score, endothelin and high-sensitive C-reactive protein levels in the GXDS group were substantially superior than those in the placebo group, and the differences between the two groups were statistically significant (P<0.05). Similar results were obtained in the per protocol population analysis of 177 patients. Three cases of MACES were reported in this study (1 in the GXDS group and 2 in the placebo group), and no serious adverse events occurred.@*CONCLUSIONS@#GXDS can significantly alleviate depression and anxiety, relieve symptoms of angina, and improve quality of life in patients with CHD after PCI. (Registration No. ChiCTR1800014291).

Research advances in the correlation between chronic subjective tinnitus and anxiety state / 临床耳鼻咽喉头颈外科杂志

Tinnitus and anxiety disorder are common clinical symptoms. Comorbidity between tinnitus and anxiety state is increasing year by year. The relationship between tinnitus and anxiety state has always been a hot topic, and this paper reviews the literature on the relationship between chronic subjective tinnitus and anxiety state in recent years.

Género y conductas ansiosas en estudiantes universitarios

Resumen Las diferencias de oportunidades de género en el campo de la ciencia y tecnología son aún una brecha, a esto se suma las probables afectaciones psicológicas, emocionales que son de interés en el estudio porque analiza y relaciona de forma objetiva las implicaciones de género y riesgos por predisposición a conductas ansiosas en estudiantes de ciencia y tecnología de la universidad. Los participantes fueron de 4to. y 5to. año, de diferentes especialidades, la muestra estuvo constituida por 368 (192 mujeres y 176 hombres), que realizan actividades de investigación. Se aplicaron el cuestionario sobre Implicaciones de género y la escala del IDARE (Inventario de Ansiedad Rasgo-Estado) para medir ansiedad. Los resultados ponen de manifiesto que las estudiantes participan más en actividades de investigación pero también obtienen mayores niveles de ansiedad "estado". Se evaluó la vida familiar, el vivir solos, con familiares, tareas dentro del hogar, participación y aportes al conocimiento científico. Los estudiantes muestran mayor ansiedad "estado" al participar en círculos de estudio, por ser parte de investigaciones financiadas, frente a la paternidad y por responsabilidad económica en el hogar. Resaltar que hay claros indicios de afectaciones (ansiedad) a la salud psicológica-emocional por segregación vertical y horizontal de género.

Abstract The differences in gender opportunities in the field of science and technology are still a gap, in addition to the probable psychological and emotional effects that are of interest in the study because it analyzes and objectively relates the implications of gender and risks for predisposition to anxious behavior in university science and technology students. The participants are 4th and 5th year, of different specialties, the sample was constituted by 368 (192 women and 176 men), who carry out research activities. Methods: Two instruments were applied: a questionnaire on Gender Implications and the IDARE scale to measure anxiety. Results show that students participate more in research activities but also obtain higher levels of "state" anxiety. Family life, living alone, with relatives, tasks within the home, participation and contributions to scientific knowledge were evaluated. Students show greater anxiety "status" when participating in study circles, as part of funded research, as opposed to paternity and economic responsibility in the home. Highlight that there are clear indications of affectations (anxiety) to psychological health emotional by vertical and horizontal segregation of gender.

Clinical Study on Yiqi Yangxin Dingzhi Prescription for Anxiety State of Patients with Chronic Obstructive Pulmonary Disease / 中国中医药信息杂志

Objective To observe the effects of Yiqi Yangxin Dingzhi Prescription on anxiety state of patients with chronic obstructive pulmonary disease (COPD). Methods Randomized, parallel controled, single-blind research plan was used. Totally 80 patients with COPD were randomly divided into observation group and control group, with 40 cases in each group. Both groups received COPD stable maintenance treatment. On this basis, observation group was given Yiqi Yangxin Dingzhi Granules, while control group was given TCM simulator, one dosage per day, twice a day. The treatment lasted for two weeks both groups. TCM symptom scores, COPD assessment test (CAT) scores, and Hamilton Anxiety Scale (HAMA) scores before and after treatment in the two groups were observed. The safety indexes were monitored. Results Compared with before treatment, the TCM symptom scores, CAT scores, and HAMA scores of the two groups after treatment were significantly lower (P＜0.05). After treatment, the improvement degree of the TCM symptom total scores [(5.04±1.90) vs (2.27±1.83), the improvement degree of the CAT total score [(4.51±1.36) vs (1.81±1.47)], and the improvement degree of the HAMA total score [(5.32±2.78) vs (2.76±1.19)] in the observation group were better than the control group, with statistical significance (P＜0.05). No significant adverse events occurred in both groups. Conclusion Yiqi Yangxin Dingzhi Prescription can effectively improve the clinical symptoms of the patients with COPD and the life quality of the patients, and it has high safety.

Efectos de un programa de inteligencia emocional en la ansiedad y el autoconcepto en mujeres con cáncer de mama / Effects of an emotional intelligence program in anxiety and self-concept in women with breast cancer

El estudio tiene como objetivo evaluar los efectos de un programa de inteligencia emocional en la ansiedad y el autoconcepto en mujeres con cáncer de mama sometidas a cirugía. Se utilizó una muestra de 81 mujeres, 39 pertenecientes al grupo de intervención y 42 al grupo control. El estudio utilizó un diseño cuasiexperimental de medidas repetidas pretest-postest con grupo de control. Para evaluar el efecto del programa se administraron tres instrumentos de evaluación, el TMMS-24, Fernández-Berrocal, Extremera y Ramos (2004), la Escala de Autoconcepto AF5 (García y Musitu, 1999), y el STAI Estado de Spielberger, Gorsuch y Lushene (1982). Los resultados de los ANCOVAs postest confirman mejoras estadísticamente significativas en el grupo de intervención en las variables de claridad emocional, reparación emocional, en todas las subescalas del autoconcepto, así como, una disminución de la ansiedad en las mujeres con cáncer de mama. Por otro lado, se observó que existen interacciones entre la variable tiempo de diagnóstico y las variables dependientes.

The study aims to assess the effects of an emotional intelligence programme on anxiety and seft-concept in women with breast cancer who have undergone surgery. The study sample consists of 81 women, 39 belonging to the intervention group and 42 to the control group. The study used a cuasi-experiment design of repeated pre-test-post-test measures with control group. To evaluate the program's effect, three assessment tools were employed, TMMS-24 (Fernández-Berrocal, Extremera y Ramos, 2004), AF5 self-concept scale (García y Musitu, 1999), and STAI (Spielberger, Gorsuch y Lushene, 1982). The results of the ACNOVA postest show statistically significant improvements in the intervention group in the variables of emotional clarity, emotional reparation, in all the subscales of self-concept, as well as, a decrease in anxiety in women with breast cancer. On the other hand, it was noted that there are interactions between the variable of diagnosis time and the dependent variables.

Niveles de ansiedad y su relación con los trastornos temporomandibulares / Anxiety levels and their relationship to temporomandibular disorders

El diagnóstico de los trastornos temporomandibulares es un tema muy controvertido dentro del campo de la salud, desde una perspectiva psicológica son muy escasas las referencias en este sentido, sobretodo las enfocadas a analizar los niveles de ansiedad en estos pacientes. En los últimos años se han realizado diferentes investigaciones que validan la inclusión de factores psicológicos como parte de la etiología del diagnóstico, dentro de los factorespsíquicos más asociados se presentan la ansiedad como rasgo y la ansiedad como estado. El propósito de este trabajo es presentar una revisión sobre la relación existente entre los niveles de ansiedad y los trastornos temporomandibulares.

The diagnosis of temporomandibulardisorders is very controversial within the fieldof health issue, from a psychological perspectiveare very few references in this regard,especially focused on analyzing anxiety levelsin these patients. In recent years there have beenvarious studies that validate the inclusionof psychological factors as part of the etiology,diagnosis, within the psychological factorsmost associated trait anxiety and state anxietyas presented. The purpose of this paper is topresent a review of the relationship betweenanxiety levels and temporomandibular disorders.

Factores sociodemográficos y hospitalarios relacionados con el nivel de ansiedad en familiares con pacientes pediátricos / Social, demographic, and hospital factors related to anxiety levels among relatives of pediatric patients / Fatores sociodemográficos e hospitalares relacionados com o nível de ansiedade em familiares com pacientes pediátricos

Introducción: La asistencia al niño hospitalizado y su familia es uno de los ámbitos que hoy requiere un esfuerzo por investigar. Conocer los factores relacionados con la ansiedad que viven los familiares en la UCIP, abre caminos para desarrollar modelos de intervención y Planes de Cuidados de Enfermería dirigidos a favorecer el afrontamiento y mejorar el bienestar familiar intrahospitalario. Objetivo: Determinar la relación de los factores sociodemográficos y hospitalarios con el nivel de ansiedad que presentan los familiares con pacientes hospitalizados en la unidad de cuidados intensivos pediátricos (UCIP). Metodología: Estudio cuantitativo, descriptivo y transversal. Se utilizó un instrumento de elaboración propia para la identificación de factores sociodemográficos y hospitalarios; y la escala de Inventario de Ansiedad Estado-Rasgo de Spielberger (IDARE) para la medición del nivel de ansiedad. Resultados: 34 familiares que participaron -11.8% (4) hombres; y 88.2% (30) mujeres- la edad promedio fue de 29 años, las puntuaciones de ansiedad estado y ansiedad rasgo indican que al no conocer algún albergue se presenta una diferencia significativa en el nivel de ansiedad estado de los familiares (X

Introduction: Aid to hospitalized children and their relatives is an issue which requires further research. Knowing the factors related to the anxiety that these children's relatives experience in the PIUC can broaden the scope to develop intervention models and Nursing Care Plans to address these issues and improve the intra-hospital family wellbeing. Objective: To determine the relationship between the social, demographic, and hospital factors with the levels of anxiety experienced by the relatives of hospitalized patients in the Pediatric Intensive Care Unit (PICU). Methodology: Quantitative, descriptive, and transversal study. An own-designed instrument to identify social, demographic, and hospital factors, and the Spielberger's State-Trait Anxiety Inventory (STAI) to estimate the levels of anxiety were used. Results: Thirty four relatives participated, 11.8% (4) were male and 88.2% (30) female. The average age was 29 years old. The anxiety state and trait scores suggest that, when information on shelters in not available, there are significant differences in the state of anxiety (X

Introduçãoa: assistência da criança hospitalizada e da sua família, é um dos âmbitos que na atualidade requer um esforço para pesquisar. Conhecer os fatores relacionados com a ansiedade que experimentam os familiares na UCIP, abre caminhos para desenvolver modelos de intervenção e Planos de Cuidados de Enfermagem dirigidos a favorecer o enfrentamento e melhorar o bem-estar familiar intra-hospitalar. Objetivo: Determinar a relação dos fatores sociodemográficos e hospitalares com o nível de ansiedade que apresentam os familiares com pacientes hospitalizados na Unidade de Cuidados Intensivos Pediátricos (UCIP). Metodologia: Estudo Quantitativo, descritivo e transversal. Utilizou-se um instrumento de elaboração própria para a identificação de fatores sociodemográficos e hospitalares; e a escala de Inventário de Ansiedade Estado-Traço de Spielberger (IDARE) para a medição do nível de ansiedade. Resultados: 34 familiares participaram, 11.8% (4) homens e 88.2% (30) mulheres, a média da idade foi de 29 anos, as pontuações de ansiedade estado e ansiedade traço, indicam que quando conhecer algum abrigo se apresenta uma diferença significativa no nível de ansiedade estado dos familiares (X

Validación del Inventario de Ansiedad Estado - Rasgo (STAIC) en niños escolarizados entre los 8 y 15 años / Validation of the State-Trait Anxiety Inventory (STAIC) in school children between the ages of 8 and 15

The purpose of this investigation was to standarize State - Trait Anxiety Inventory for Children (STAIC) in children and adolescents between the ages of 8 and 15. The standarization of the STAIC questionnaire is the result of the evaluation of 670 children of both genders, in 35 public and private educational institutions in the city of Medellín, Colombia. The data base had an analysis through the program SPSS version 10.0. The analysis consisted in evaluating the structural properties of the test through the construct validity found in the factorial analysis with varimax rotation by the principal components method and the reliability by the Cronbach alpha with the intraclass correlation coefficient. The analysis of the above conditions brought up a result of six factors in its factorial analysis. A Cronbach alpha of 0.70 was established.

Esta investigación tuvo como propósito estandarizar el Inventario de Ansiedad Estado - Rasgo (STAIC) en niños y adolescentes entre 8 y 15 años de edad. La estandarización del cuestionario STAIC, es el resultado de la evaluación de 670 niños de ambos géneros, en 35 instituciones educativas públicas y privadas de la ciudad de Medellín, Colombia, La base de datos tuvo un análisis a través del programa SPSS versión 10.0. El análisis consistió en evaluar las propiedades estructurales de la prueba a través de la validez de constructo hallada bajo el análisis factorial con rotación varimax por el método de componentes principales y la confiabilidad por alpha de Cronbach con coeficiente de correlación intraclase. El análisis de dichas condiciones arrojó como resultado seis factores en su análisis factorial. Se estableció un alpha de Cronbach de 0.70.