A Case of Adnexal Tumor with Folliculosebaceous-apocrine Differentiation: Literature Review and Nomenclature Clarification / 대한피부과학회지

No abstract available.

Sebaceous carcinoma with apocrine differentiation: A rare entity with aggressive behavior.

Sebaceous carcinomas are rare neoplasms but have aggressive behavior. Although they can be found anywhere in the body ocular region is the most common site which comprises 75% of all cases of sebaceous carcinomas. Due to their rarity, varied histopathological features, and diverse clinical presentation, their diagnosis is often delayed, sometimes by a year. They are divided on the basis of histological differentiation into well and poorly differentiated. Apocrine differentiation is a still rarer fi nding and only two cases have been reported in the literature so far. We report a case of sebaceous carcinoma with apocrine differentiation in a 60-year-old male who presented with a painless swelling in right upper eyelid for 2 months which was gradually progressive. Computed tomography (CT) scan was performed and a provisional diagnosis of hemangioma was made. The mass was excised and histopathological examination revealed it to be sebaceous carcinoma. However, there were areas with decapitation secretions and granular eosinophilic cytoplasm. These were positive for cytokeratin (CK) 7 and CK 19 which confi rmed their apocrine nature. Therefore, a fi nal diagnosis of sebaceous carcinoma with apocrine differentiation was made. Thus, it can be concluded that ocular sebaceous carcinomas with apocrine differentiation are extremely rare and have signifi cant clinical importance since they can mimic a benign lesion and the nature of surgical intervention and follow up is more aggressive than that of simple sebaceous carcinoma alone.

A Case of Chondroid Syringoma with Folliculosebaceous-Apocrine Differentiation / 대한피부과학회지

Chondroid syringoma is a sweat gland tumor which is composed of a mixture of epithelial cells and mesenchymal tissue. It is referred to as a mixed tumors. Mixed tumor with follicular, sebaceous and apocrine differentiation are considered to be an expression of the common embryologic origin of elements of the folliculosebaceous-apocrine unit. A 74 year-old man presented with an asymptomatic, firm, pigmented nodule on the right cheek. Histologically, it showed numerous aggregates of cuboid epithelial cells with tubuloalveolar structures and keratinous cysts within a chondroid stroma. This was consistent with a chondroid syringoma. We herein describe an unusual chondroid syringoma with folliculosebaceous-apocrine differentiation.

A Case of Nodular Hidradenoma with Apocrine Differentiation / 대한피부과학회지

Nodular hidradenoma is a relatively infrequent benign tumor that shows differentiation from or toward the structure of the eccrine sweat gland. We report a case of nodular hidradenoma with apocrine differentiation in a 74-year old female who had an asymptomatic, 3.5x2.7x1.0cm-sized, smooth-surfaced, round, erythematous to bluish tumor mass with cystic grape-like nature on the right thigh for 3 years. Histological findings showed a well-circumscribed tumor composed of solid portions with fusiform basophilic cells and clear round cells, cystic spaces, tubular lumina, squamoid feature and decapitation secretion.

A Case of Apocrine Mixed Tumor / 대한피부과학회지

Mixed tumor of the skin, so called chondroid syringoma, is a benign epithelial neoplasm with glandular or ductal differentiation surrounded by myxoid stroma. It is most frequently located on the head and neck and presents as an asymptomatic, firm, subcutaneous nodule. Mixed tumor with follicular, sebaceous and apocrine differentiation is considered as an expression of the common embryologic origin of elements of the folliculo-sebaceous-apocrine unit. We report a case of mixed tumor of the skin with follicular, sebaceous and apocrine differentiation.

A case of chondroid syringoma with folliculosebaceous-apocrine differentiation / 대한피부과학회지

Chondroid syringoma is referred as mixed tumor because it has epithelial structure and mesenchymal elements. Mixed tumors could be divided into two distinct types, eccrine and apocrine. Mixed tumor with follicular, sebaceous and apocrine differentiation is considered as an expression of the common embryologic origin of elements of the folliculosebaceous-apocrine unit. A 32-year old manpresented with an asymptomatic firm erythematous nodule on the left cheek. Histologically, it showed typical features of chondroid syringoma with tubules exhibiting branching and cystic dilatation in the myxoid and chondroid stroma. Our case is unique in that the tumor arose from follicular infundibulum with follicular, sebacesous and apocrine differentiation.

A Case of Apocrine Poroma

Apocrine poroma is a benign cutaneous adnexal neoplasm differentiating in the direction of sebaceous and apocrine glands, and follicular germs. The clinical appearance of apocrine poroma is not distinctive, and the histologic finding is similar to that of eccrine poroma, which is typified by proliferation of poroid and luminal cells in continuity with the epidermis. But sebaceous, apocrine or follicular differentiation may also be found in the case of apocrine poroma. We herein report a case of apocrine poroma on the scalp. This case exhibited apocrine and sebaceous differentiation, and connection to an adjacent follicular epithelium.

Invasive Extramammary Paget Disease: A Report of 2 Cases with Immunohistochemical and Ultrastructural Findings

We present 2 cases of invasive extramammary Paget disease occuring in the vulva area of a 60 year old female, and in the scrotal and penile area of a 63 year old male patient. The histologically typical Paget cells were not only seen in the surface epithelium but were also involved in the outer root sheath of the hair follicles. Stromal infiltration of tumor cells into the upper dermis were present in both cases, however, no underlying primary sweat gland carcinoma was present. Metastatic foci of inguinal lymph nodes showed apocrine-type epithelium with abundant eosinophilic granular cytoplasm, which were positive for anti-CEA and GCDFP-15, as well as eccrine-type epithelium containing mucinous secretory materials in the lumen and the cytoplasm. Ultrastructural findings showed interdigitating plasma membranes with prominent desmosomes between the Paget cells, intracytoplasmic tonofibrils, intracellular tubules, lipid vacuoles, and enlarged mitochondria. Histological, immunohistochemical, and ultrastructural findings suggested that Paget cells showed both eccrine and apocrine differentiation.