Relationship between leptin level of IGR patients and the intima-media thickness of carotid arterial / 实用医学杂志

Objective To investigate the relationship between leptin level of IGR patients and intima-media thickness (IMT) of carotid arterial. Methods One hundred and eighteen IGR patents were enrolled into the following three groups according to the result of oral glucose tolerance test (OGTT): 38 cases of the purely impaired fasting glucose (IFG) group, 42 cases of the purely impaired glucose tolerance (IGT) group and 42 cases of the IFG combining with IGT (IFG + IGT) group. Thirty-eight cases with normol glucose tolerance (NGR) were enrolled in the NGR group. The blood fat, fasting blood-glucose (FBG), fasting insulin (insulin), fasting C peptide , 2 h-postprandial blood glucose , 2 h-insulin , 2 h-C peptide , glycosylated hemoglobin (HbA1C), C-reactive protein (CRP), body mass index (BMI), leptin and IMT were determined in patients of the three groups and the healthy controls. The multiple linear regression was used to analyze the relationship between leptin level and IMT , and person correlation was further used to analyze the affinity degree between leptin level and IMT. Results Compared with the NGT group, the inter-group comparison showed that leptin level was significantly increased in the IFG, IGT and (IFG + IGT) groups (P < 0.05, respectively). Compared with the IFG and IGT groups, IMT and the leptin level were increased in the (IFG + IGT) group (P < 0.05, respectively). The multiple linear regression analysis showed that leptin level was correlated with the increase of IMT in the (IFG + IGT) group (P < 0.05), but not in the IFT group and the IGT group. Conclusion The leptin level in the IGR group and the IMT in the IFG + IGT ) group were significantly increased , the leptin level was closely associated with IMT.

Grosor de íntima-media carotídea en niños sanos por técnica ecográfica computarizada / Arterial intima-media thickness in healthy Chilean children using an ultrasonographic computerized technique

Introduction: Vascular endothelium is a target organ in metabolic syndrome. Ultrasound measurement of intimae-media thickness (IMT) is used in adults to predict cardiovascular risk, but normal values in children are unknown. Objective: To describe arterial intima-media thickness in healthy children, by means of an ultrasonographic technique and a specific software. Subjects and Methods: Seventy-four healthy children, 39 males, ages 5-15 y.o., body mass index (BMI) 10-85 percentile were selected from an upper-middle socioeconomic background. Subjects were grouped by age. Three measurements were carried out to each subject at the middle third of the right common carotid for maximal intima-media thickness using a Phillips iU22 ultrasound system; a 12-5 MHz lineal transducer and QLAB advanced quantification software, which includes a specific program for automated IMT measurements, were used. Weight, stature, BMI, and abdominal circumference were registered. Results: No significant differences in the IMT values according to age or gender were found. Median IMT was 0.41 mm (0.40-0.56 mm); 5 children presented IMT 0.50-0.56 mm (> 75th percentile). The median IMT for those children with abdominal circumference < 50th percentile was the same for those over 50th percentile (0.41 mm). Conclusions: Measurements of carotid intima-media thickness for healthy Chilean children were found to be in the expected range, in relation with adult known values.

Introducción: Uno de los sitios de daño asociado a síndrome metabólico es el endotelio vascular; la medición ecográfica del grosor de intima-media carotídea (GIMC) es usado en adultos como un indicador de daño vascular, pero no se conocen valores de normalidad en niños. Objetivo: Estudiar el grosor de intima-media carotídea mediante programa computacional específico, en niños chilenos sanos. Pacientes y Método: Se seleccionaron 72 niños (percentiles 10-85 de IMC sin enfermedad conocida), 5 a 15 años de edad, de estratos socioeconómicos medio-altos, 33 niñas y 39 varones, agrupados por tramos de edad; se les efectuó y promedió 3 mediciones ecográficas en tercio medio de arteria carótida común derecha, mediante equipo Phillips modelo ÍU22; se usó un transductor lineal 12-5 MHz y un software de cuantificación avanzada QLAB, con programa específico de medición automática para grosor de GlMC Además se les midió: peso, talla, 1MC, perímetro abdominal (PA). Se solicitó previamente el consentimiento escrito a padres y niños. Resultados: No hubo diferencias en las mediciones de GlMC de acuerdo a edad o sexo, la mediana fue de 0,41 mm (0,40-0,56 mm); hubo 5 niños entre 0,50 y 0,56 mm (> percentil 75); no hubo correlación con PA o 1MC; los niños con PA < percentil 50 tuvieron una mediana de GlMC igual a aquellos con PA > percentil 50 (0,41 mm). Conclusiones: Las mediciones de grosor de intima-media carotídea de niños y adolescentes chilenos sanos mediante técnica ecográfica y programa computarizado, están dentro de valores esperados para la edad, comparados con valores conocidos de adultos.

Effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension / 中国基层医药

Objective To investigate inhibitory effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension. Methods 104 patients with mild or mid essential hypertension were randomly divided into three groups, which include telmisartan group( telmisartan 80 mg/d PO), ramipril group( ramipril 5 mg/d PO), and control group( other anti-hypertension agents). Blood pressure was monitored during treatment. Carotid arterial intima-media thickness(CIMT) were measured in all patients at beginning and patients who had the 12 months course. Results There were 91 patients who had the 12 months course,which include telmisartan group33 cases,ramipril group28 cases, and control 30 cases. The CIMT was significantly decreased in telmisartan group and ramipril group ( all P < 0. 05 ), and not changed in control while blood pressure fall effectively. In ramipril, group5 cases were ceased the course because of severe cough. Conclusion Both telmisartan and ramipril could decrease blood pressure and CIMT effectively, and there were less side effects in telmisartan group.

Application of Carotid Arterial lntima-media Thickness Measurement in the Diabetic Retinopathy / 中国慢性病预防与控制

Objective To investigate the significance of measuring carotid arterial intima-media thickness(IMT) and diabetic retinopathy(DR).Methods 76 diabetic patients were divided into three groups:no diabetic retinopathy(NDR),nonpmliferative diabetic retinopathy(NPDR),and proliferative diabetic retinopathy(PDR).20 helath people were chosen as control All subjects were examined by ColorDoppler imaging on the carotid arterial intima-media thickness.Results The mean IMT was significantly higher in T_2DM patients than in normal control group(P

Correlation of Microinflammation,Nutrition and Common Carotid Arterial Intima-Media Thickness / 上海第二医科大学学报

Objective To study the relationship of microinflammation,nutrition and common carotid artery intima-media thickness(CCA-IMT) for the early prevention and interference of ischemic stroke. Methods(CCA-IMT was) measured by carotid arterial ultrasound in 250 elderly subjects.The levels of serum high-sensitivity C-(reactive) protein(hsCRP),ferritin,albumin,pre-albumin and transferrin were assayed at the same time.According to the results of CCA-IMT,all the subjects were divided into five groups:

Effect of Rosuvastatin on Carotid Arterial Intima-media Thickness of Elderly Patients / 药物流行病学杂志

Objective:To investigate the effect of rosuvastatin on carotid arterial intima-media thickness of elderly patients and its comparison with simvastatin.Method:126 patients hospitalized during January and August 2008 were randomly divided into a treatment group and a cotrolled group.All the patients were male and older than 70 years old,and their mean age was 78.9?8.8 years.63 patients accepted the rosovastatin therapy and 63 patients accepted the simvastatin therapy.Result:After 8-weeks'therapy,CIMT was reduced from 1.58?0.24mm before the treatment to 1.44?0.22mm after it.There was no difference between the two groups in decreasing CIMT.No adverse events related to the study medication were observed.Conclusion:The treatment with rsuvastatin can prevent the increase of carotid arteriosclerosis in eldlerly patients without any difference in decreasing CIMT,compared with simvastatin.