RESUMO
Zika virus (ZIKV) was first isolated in 1947. It is known to circulate mainly in tropical areas and can be transmitted through Aedes mosquitoes. In 2015, an outbreak of ZIKV began in Brazil and then spread rapidly to the Latin Americans and Caribbean. Accumulating evidence indicates that there are associations between ZIKV infection and human nervous disorders, such as the occurrence of microcephaly in neonates and Guillain-Barré syndrome in adults. The current ZIKV outbreak has been declared a public health emergency of international concern. Here, we review the virological features, transmission and epide-miological characteristics of ZIKV and the clinical featrues and prevention of ZIKV infection.
RESUMO
Objective To investigate the diversity of mosquito-borne viruses in Xinjiang , China, and to identify mosquitos-borne viruses of medical importance rapidly .Methods The virus-derived RNAs in mosquitos captured in wild were screened and confirmed by using Illumina deep sequencing approach and reverse transcription PCR , respectively .The alignment analysis was performed by using gene sequences from GenBank.Results One hundred and forty-four Culex Flavivirus ( CxFV, Flavivirus genus, Flaviviridae) specific sequences were identified .The overlapping reads were assembled into 7 uncontinuous viral genomic contigs.The gaps between the contigs were further filled by RT-PCR products, which resulted in reconstruc-tion of viral genomic 5′and 3′terminus (687 nt and 411 nt).Phylogenetic analysis showed that the newly identified CxFV belonged to America/Asian genotype , which specifically clustered into a clade with other CxFV strains from China mainland ,sharing 98.2%-99.5%homologies in nucleotide sequences and 99.5%in amino acids sequences among them .Conclusion Illumina deep sequencing approach was successfully applied to arthropod-borne virus surveillance .The recently emerged Culex Flavivirus was detected for the first time in Xinjiang, China.