Nutritional status of patients with pulmonary tuberculosis and anti-tuberculosis treatment effect / 中国热带医学

@#Abstract: Objective To investigate the nutritional status of patients with pulmonary tuberculosis and its effects on conventional anti-tuberculosis treatment, so as to provide a basis for improving the efficacy of conventional treatment of pulmonary tuberculosis. Methods The relevant data of 168 patients with pulmonary tuberculosis admitted to Suining Central Hospital from April 2020 to April 2022 were retrospectively analyzed. Nutritional status of the patients before treatment was investigated using the Mini Nutritional Assessment (MNA) score, and the influencing factors of nutritional status before treatment were analyzed. Therapeutic effects of anti-tuberculosis drugs in the non-nutritional risk group and the nutritional risk group were comparatively analyzed. Results Among the 168 patients, 64 were assessed as having good nutritional status before treatment, 59 had the risk of malnutrition and 45 were malnourished according to the MNA score. Univariate analysis and linear regression analysis showed that age, underlying diseases, and clinical symptoms were factors affecting the MNA score before treatment (t=3.173, 3.718, 2.018, P all<0.05); whereas gender and education level were not factors affecting MNA score before treatment (t=0.065, 0.059, P all>0.05). According to the MNA score before treatment, the patients were dividedinto a non-nutritional risk group (MNA score > 23.5) and a nutritional risk group (MNA score ≤23.5). The negative conversion rate of sputum bacteria, effective rate of focal absorption in the non-nutritional risk group were 92.19% (59/64)and90.63% (58/64) , respectively, which were significantly higher than corresponding 79.85% (82/104)and76.92% (80/104) in the nutritional risk group. The drug resistance rate, adverse reaction rate, and average treatment cost of the no nutritional risk group and nutritional risk group were 7.81% (5/64) and 21.15% (12/104), 15.63% (10/64) and 31.73% (33/104), (0.62±0.13) million yuan and (0.89±0.26) million yuan, respectively, with significant differences (χ2=5.228, 5.071, 7.685, 5.396, 7.728, P all<0.05). Conclusions Patients with pulmonary tuberculosis exhibit poor nutritional status before treatment. The patients’nutritional status is easily affected by age, underlying diseases, and clinical symptoms, thereby affecting the effect of anti-tuberculosis treatment. Therefore, early nutritional intervention for tuberculosis patients should be recommended in order to prevent malnutrition and enhance the effectiveness of anti-tuberculosis treatment.

Excessive interdialytic weight gain and associated factors

ABSTRACT Excessive interdialytic weight gain (IDWG) may be associated with numerous factors that are discussed little in the literature. The aim of the present study was to evaluate factors associated with excessive IDWG in patients on hemodialysis. A cross-sectional study was conducted with 197 adults on hemodialysis at a satellite clinic in the city of Jaboatão dos Guararapes, Brazil. We calculated %IDWG by the mean difference among 12 hemodialysis sessions, with >4.5% considered excessive. The conceptual model considered socioeconomic, demographic, clinical, anthropometric and laboratorial variables. Excessive IDWG was found in 28.4% of the sample. In the final adjusted Poisson regression model, three variables remained independently associated with excessive IDWG: age between 20 and 59 years (adjusted prevalence ratio [PRadjusted]= 1.87, 95% CI: 1.21-2.88), household income between one and two times the minimum monthly salary (PRadjusted=2.14, 95% CI: 1.36-3.44) and

RESUMEN El aumento de peso interdiálisis (APID) excesivo puede asociarse a numerosos factores, pero todavía es poco discutido en la literatura. El objetivo fue evaluar los factores asociados al APID excesivo de pacientes en hemodiálisis (HD). Estudio transversal, que incluyó a 197 pacientes adultos en HD, y fue realizado en una clínica satélite ubicada en Jaboatão dos Guararapes/PE. Para el análisis del % APID, se calculó el promedio de la diferencia de peso de 12 sesiones de hemodiálisis, considerándose excesivo el valor >4,5%. El modelo conceptual consideró variables socioeconómicas, demográficas, clínicas, antropométricas y de laboratorio. El APID excesivo estuvo presente en el 28,4% de la muestra y, tras el ajuste para el modelo final obtenido por la regresión de Poisson, tres variables permanecieron independientemente asociadas al APID excesivo: edad entre 20 y 59 años (razón de prevalencia ajustada - RPajustada= 1,87 IC95% 1,21-2,88), renta familiar entre 1 y 2 sueldos mínimos (RPajustada= 2,14 IC95% 1,36-3,44) y nivel educacional <9 años de estudio (RPajustada= 1,78 IC95% 1,15-2,76). Los resultados mostraron una asociación entre APID excesivo con algunos factores, siendo la renta familiar baja la más fuertemente asociada, seguida por la edad adulta no-anciana y el bajo nivel educacional.

Comparison of Malnutrition Prevalence Between Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients: A Cross-sectional Study

Introduction: Introduction: Malnutrition is a serious unresolved nutritional problem amongst dialysis patients associated with increased mortality and morbidity and prevalence differs according to dialysis modalities. This study compared protein- energy malnutrition (PEM) prevalence in haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. Methods: A total of 155 HD and 90 CAPD patients were enrolled. PEM prevalence was determined using body mass mdex (BMI), serum albumin, Dialysis Malnutrition Score (DM5) and dietary intake. Results: CAPD patients had significantly higher BMI (24.1 � 4.8 kg/m2 vs. 22.7 � 4.8 kg/m2 p=O.024) and mid-arm muscle area (32.1 � 12.4 cm2 vs. 29.5 � 15.9 cm2 p=O.044) than HD patients. They also had significantly lower serum albumin (31 � 5 g/L vs. 35 � 6 g/L; p5 years were independent risk factors of PEM hi dialysis patients. Conclusion: Periodic nutritional assessments, education and dietary counseling should be emphasised in these patients as a preventive measure of PEM.