RESUMO
Objective To investigate changes of thyroid functions in high-risk pregnant women suffering from gestational diabetes mellitus(GDM).Methods From Feb.2013 to Jun.2014, 80 cases of high-risk preg-nant women suffering from GDM were selected as group A1(high-risk group), 80 cases of GDM pregnant women were selected as group A2(diabetic group), and 80 cases of healthy pregnant women were selected as group A 3 ( the control group ) .Indicators of thyroid function for the three groups were detected and compared .Results The positive rate of TPOAb in group A1 and A2 was significantly higher than that in group A 3, and the difference had statistical significance(P0.05), while FT4 level in group A1 and A2 was both significantly lower than that in group A3, and the difference had statistical significance (P<0.05).Conclusions The probability of thyroid dysfunction in GDM pregnant women and high-risk pregnant women is higher than that in the normal healthy pregnant women . For pregnant women with a family history of diabetes , thyroid functions should be checked comprehensively to prevent thyroid dysfunction .
RESUMO
Objective To investigate HLA-DPB1, DQB1 gene alleles and their correlation with autoantibodies in type 1 diabetes mellitus. Methods Sequence-based typing was used to determine the alleles of HLA-DPB1 and -DQB1 in 68 patients with type 1 diabetes and 50 healthy controls. Autoantibodies 〔glutamic acid decarboxylase antibody (GADA), islet cell antibody (ICA), insulin autoantibody (IAA)〕were detected by ELISA. Results Compared with the controls, the frequencies of DPB1*0402 and DQB1*0301 were significantly lower in type 1 diabetics (11.76%, 5.15% vs 30.00%, 22,00% respectively, P