Autopsy findings of SUDEP in adolescence

@#Sudden unexpected death in epilepsy (SUDEP) is a rare in children; the risk of SUDEP in children is up to 10-fold less than adults. Herein, we report a case of SUDEP in a 14-year-old boy. The post-mortem findings in neuropathological examination in SUDEP are not pathognomonic. Tongue and lip bites marks are only an indication of a seizure before death. Basically, there are no lesions that could explain the incidence of seizures before death. However, post-mortem examination is mandatory in order to determine the diagnosis of SUDEP. Autopsy, histopathological, and toxicologic examinations and a proper medical history of epilepsy are required to come to diagnosis of SUDEP. This case report further demonstrates the importance of medicolegal autopsy in allegedly dead victims.

Autopsy Findings in Fetuses with Oligohydramnios / 대한비뇨기과학회지

PURPOSE: After 16 weeks of gestational age, amniotic fluid is mainly consisted fetal urine. There is a close correlation between oligohydramnios associated with urinary tract anomaly and pulmonary development. Therefore, fetuses with oligohydramnios starting in the second trimester are considered to have uniformly fatal outcomes. We try to survey clinical characteristics of fetuses with oligohydramnios on autopsy and to find the need of perinatal management in fetuses with urinary tract anomaly and oligohydramnios which is occurred since second trimester. MATERIALS AND METHODS: We retrospectively analysed gestational age at presentation, maternal age, causes of oligohydramnios, external physical examination, prenatal sonographic findings, underlying urologic anomalies, associated anomalies of other organs and ultimate outcomes in eighteen fetuses with oligohydramnios among 301 autopsy fetuses from 1986 to 1991. RESULTS: It occurred predominantly in male as a ratio of 2.6:1 Gestational age of fetuses at presentation ranged from 21 to 47 weeks(average: 32.6) and maternal age from 20 to 33 years(average: 28.3). Causes of oligohydramnios in 18 fetuses ware fetal renal anomalies with intrauterine growth retardation(IUGR)(6), fetal renal anomalies(3), fetal death in uterine(3), urinary tract obstruction with IUGR(2) et al Inaccuracy rate between prenatal sonographic findings and autopsy findings was 53.8%, 0% in fetuses with urologic anomalies and with non-urologic anomalies, respectively. Underlying urinary tract anomalies consisted of bilateral renal dysplasia(4), posterior urethral valves(2), bilateral renal agenesis(1), bilateral renal hypoplasia(1), unilateral renal dysplasia and contralateral renal hypoplasia(1), infantile polycyctic kidney(1) et al. The most frequent anomaly of other organ was respiratory system anomalies, especially pulmonary hypoplasia. The prognosis in our cases with oligohydramnios was dismal as much as all fetuses except one, still birth, died of respiratory failure at perinatal periods. CONCLUSIONS: Based on these experiences we have the policy to induce delivery and early perinatal management in cases with second or third trimester onset of severe oligohydramnics with urinary tract abnormalites.