Estudios de la naturaleza de la Efectividad y Dirección Funcional de Suplemento Biológicamente Activo en el Tratamiento Integral de la Hepatitis Alcohólica Aguda / Nature Studies of the Effectiveness and Functional Direction of Biologically Active Supplement in Comprehensive Treatment of Acute Alcoholic Hepatitis

The article examines the influence of the Biologically Active Dietary Supplement (BADS) "Oleopren Hepa" as a hepatoprotective effect in the comprehensive treatment of acute alcoholic hepatitis. During the study, the authors obtained evidence of the effectiveness and functional orientation of the BADS. The materials for the research are the data obtained during the examination and treatment of 60 patients with acute alcoholic hepatitis. All examined patients were divided into 2 groups: 1st group (main), which received dietary supplements; the 2nd group (control) who did not receive this supplement. The average age of patients was 38.7 ± 9.3 years. The study was carried out based on the gastroenterological department of the city clinical hospital. As a result of the use of BADS in the comprehensive therapy of patients with acute alcoholic hepatitis, hepatomegaly was significantly reduced, and a decrease in the levels of total bilirubin, AsAt, AlAT, GGTP and cholesterol was observed. Additional intake of a specialized product enhanced the hepatoprotective effect of the main treatment. According to the tested biochemical parameters, the dynamics were better than in the control group. The use of the BADS, in addition to comprehensive therapy, increases the effectiveness of treatment of acute alcoholic hepatitis.

Biologically active dietary supplement for correction of exchange disorders in nervous system diseases

The prescription composition of the biologically active dietary supplement (BADS) Oleopren Neuro has been scientifically substantiated through the pharmacological evaluation of the effective agents, polyprenols being the main of them. The technology of an innovative product has been developed, with the establishment of adjustable production parameters securing high organoleptic advantages and stability of the BADS. Regulated indicators of quality and nutritional value have been determined. Sanitary toxicological and hygienic safety indicators of the product under development had been studied, which allowed to establish a shelf life of two years taking the safety margin of three months into account. The possible mechanisms of the dolichols effect on the metabolic status of the organism were considered. Clinical trials of the efficiency and functional focus of a specialized product on a representative group of patients with the dyscirculatory encephalopathy (DE) of vascular genesis stages I ­ II were conducted. The BADS were included in the diet of patients, along with the basic therapy, one capsule twice a day for 10 days. The materials obtained in this article allow to recommend the developed product as an efficient means of increasing the body's resistance to adverse effects of the environment, stressful situations, as well as psychoemotional and physical stress.

Ecological assessment of executive dysfunction in anxiety

Introduction: The specialized literature states that anxiety can interfere with cognition, particularly in complex cognitive processes such as those related to executive functioning. Neuropsychological studies in anxiety disorders have confirmed the presence of deficits in executive functions, with significant changes in its components. The main aim of this study was to compare the executive performance of a sample with anxiety disorder to a control group, using an instrument that differs from the others by high ecological validity, revealing a higher predictive evidence on daily tasks. Methods: This study included 60 participants aged between 18 and 53 years that were allocated to an experimental group (n = 30; mean = 31.93; standard deviation [SD] = 10.99) and a control group (n = 30; mean = 29.63; SD = 9.07). Anxiety symptoms and the executive functioning were assessed using the Beck Anxiety Inventory (BAI) and the Behavioural Assessment of the Dysexecutive Syndrome (BADS), respectively. Results: Participants with anxiety disorders presented a significant impairment on executive functioning in general. However, we found a significant impact in tasks that involve control inhibition, design of action strategies according to the functionality and probability of success, the ability to predict or estimate and the ability to plan the action. In addition, the EG required significantly more time to execute all the tests (mean = 440.33, SD = 97.17), compared to the CG (mean = 320.90; SD = 51.27). Conclusions: Individuals with anxiety disorders have a significant impairment in their executive functioning in general, which is reflected in activities of daily living.

The Reliability and Validity of the Korean Version of Behavioral Activation for Depression Scale / 신경정신의학

OBJECTIVES: The Behavioral Activation of Depression Scale (BADS) has been reported to be a valid tool for assessing the different behavioral aspects of depression, such as activation, rumination or avoidance, and functional impairment. The aim of this study was to assess the reliability and validity of the Korean version of BADS (K-BADS). METHODS: A sample of 196 outpatients completed the K-BADS and the data were analyzed for internal consistency and factor structures. An additional 51 outpatients re-filled the K-BADS after two weeks for the test-retest reliability. To test for the validity, the Hospital Anxiety and Depression Scale (HADS), Working Alliance Inventory (WAI), Drug Attitude Inventory-10 (DAI-10), and Mindfulness Attention Awareness Scale (MAAS) were administered. RESULTS: Internal consistency of K-BADS was good (Cronbach's alpha=0.843) and principal component factor analysis revealed the four-factor structure. The K-BADS showed a reasonable test-retest reliability (r=0.863, p<0.001). The total score of K-BADS correlated significantly with the total scores of the HADS depression (r=−0.694) and HADS anxiety (r=−0.681). No correlations were found between the K-BADS and the K-WAI (r=0.170) and between the K-BADS and the K-DAI-10 (r=0.311). CONCLUSION: The K-BADS is a reliable and valid instrument for measuring the behavioral activation for depression in Korean patients with depressive symptoms.