Analysis of operation efficiency and resource allocation of clinical departments in a hospital based on data envelopment andlysis / 中华医院管理杂志

Objective:To establish a calculation model for the operational efficiency and resource allocation of clinical departments in hospitals, for references for hospitals to optimize resource allocation.Methods:The informations including hospitalization time, nursing grade, etc. of inpatients admitted by 32 clinical departments in a tertiary public hospital from January to December in 2021 were extracted. A data envelopment analysis method was conducted on the operation efficiency and input edundancy of the departments. The K-means algorithm was used to divide inpatients into 3 categories according to the level of medical workload. Taking the numbers of doctors, nurses and beds as the input indicators, and the numbers of patients in the 3 categories as the output indicators, a BCC model 1 was established to evaluate the efficiency of resources invested by clinical departments into professional human value. At the same time, a BCC model 2 was established with the total number of patients admitted and medical income as the output indicators to evaluate the efficiency of resources invested by clinical departments into economic benefits.Results:A total of 38 147 inpatients were enrolled. There were 14 departments with overall technical efficiency (OTE) =1.000 in the BCC model 1, 10 departments with OTE=1.000 in the BCC model 2, and 8 departments with OTE=1.000 in the 2 models. As for the input redundancy, 6 departments had high input redundancy in the BCC model 1, 11 departments had high input redundancy in the BCC model 2, and 4 departments had high input redundancy in both models.Conclusions:The model established by this study could effectively evaluate the operational efficiency and input redundancy of clinical departments, identify departments with high workload and low economic benefits, and provide reference for the rational allocation of medical resources in hospitals.

Basal cell carcinoma-clinico-pathological study in Eastern India in correlation with different risk factors

Objectives: To study the histological variants and mimickers of basal cell carcinoma (BCC) alongwith different risk factors among a group of patients from eastern India. Methods: The specimen for the study was sent by the dermatology department for histopathology after skin biopsy. Results: Out of 42 patients, 15 patients studied were males and the rest of the cases were females. The male to female ratio was 0.55:1. Maximum (15 cases) cases were in the age group of 50–59 years. Apart from sunlight, chronic arsenic exposure is an important risk factor of BCC. Basal cell hyperplasia and squamous cell carcinoma are the histological differential diagnosis of nodular BCC and basosquamous BCC. Conclusion: BCC is a disease of the older age group and with female preponderance in our study. Nodular basal cell carcinoma was the most common histologic type of basal cell carcinoma. The face was the most common site for BCC followed by the scalp. UV radiations and Arsenic do play role in the pathogenesis of BCC. CD10 helps differentiate superficial BCC from basal cell hyperplasia.

Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional factors GLI through bromodomain-containing protein 4 (BRD4) has recently spurred new interest as potential treatment of HH-driven MB. Through screening of current clinical BRD4 inhibitors for their inhibitory potency against glioma-associated oncogene homolog (GLI) protein, the BRD4 inhibitor

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance. The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6 (IL-6) and interferon-

Morpheaform Basal Cell Carcinoma: A Case Report with Review of Literature

Basal cell carcinoma (BCC) is the most frequently occurring skin cancer. Most cases are not life threatening, as very small proportions of BCCs metastasise. However, a high tendency to recurrence makes characterising BCCs and tumour margin areas obligatory. It will assist in better understanding their pathogenesis and in more effective treatment through prevention of recurrence and second primary disease. Various morphological subtypes have been described, nodular BCC being the most common type. Morpheaform or sclerosing BCC is a rare but high risk variant of BCC. One such case of Morpheaform, BCC in a 30-year old female patient is reported here to emphasise the nature and early diagnosis of this malignancy.

Investigating the geographical distribution of skin cancer (BCC type) in Ardabil province via GIS.

Background: Skin cancer is the most common type of cancer in most countries and it holds the first or the second place in terms of frequency in different areas of the country. BCC is the most usual type of tumor in the white skinned people, and its incidence rate rises as individuals get older, especially after age 40.Thistype of skin cancer mostly occurs in the white skinned people and, in85% of cases; it develops on the head and neck. This study aimed at examining the geographical distribution of skin cancer (BCC type) in Ardabil province through GIS. Methods: This cross-sectional study has been done on 131 cases of skin cancer with type BCC in 2007-2014. The required information such as age, sex, occupation, and the locus of BCC, was extracted from the patients' records based on their place of residence. Data analysis was performed using SPSS (version 20). ARC GIS (version 10) was used for drawing geographic maps. Results: 50.4% of the subjects were men and the mean age of them was 62.8±14.5 years. Of the subjects, 66.4% were from Ardabil city, 80.2% from urban population and 15.3% of the subjects were smokers. Of the patients, 78.5% had developed cancer in their face. Conclusions: Results showed that for control of cancer, educational interventions should be given priority, and people should be instructed about the use of personal protection equipment, like proper sunscreen cream, hat and sunshade in the workplace, as far as it is possible.

Impact of behaviour change communication among pregnant women regarding good and harmful traditional practices.

Background: Neonatal survival is influenced much by care provided by the family before, during and after delivery, which in turn is influenced by mother’s beliefs, and perceptions of her immediate family. Objective: To assess the behaviour of pregnant women regarding good and harmful neonatal care practices. 2. Implementation and assessing impact of Behaviour Change Communication (BCC) Package among pregnant women regarding good and harmful neonatal care practices. Methods: A community based intervention study was conducted in the field practice area of the Urban Health Training Centre, Department of Community Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. 200 pregnant women were enrolled purposively. Data were analyzed with Epi Info version 3.5.1. Percentages, and Chi Square Test used. Results: Due to implementation of BCC Package in intervention, good practices like giving colostrum were increased two times. Initiation of breastfeeding within 1 hour was increased 4.7 times, exclusive breastfeeding was gone up 3.8 times and induction of burping was increased 6 times. There was significant difference (P–value <0.05) between the two groups on 7th and 28th days of delivery. Harmful practices like not washing hand were decreased 3.83 times, use of dark and ill-ventilated room was decreased 2.54 times, and practice of cutting the cord with a used blade, or any unsterile scissors, knife, or sickle, broken cup was decreased 3 folds. Application of ghee/ cow dung on the cord was decrease significantly. Practices of prelacteals and use of pacifier, application of kajal, and witch craft for neonatal illnesses were reduced significantly. Conclusion: There was significant improvement in pregnant women regarding traditional neonatal practices. Some practices had not changed due to some strong cultural beliefs and influence of mother in-law and elderly females of the family.

BCC oriented model being challenged as a strategy of sustaining safe sex among MSM / 中国艾滋病性病

Objective To examine effect of intervention strategies on developing sustainable safe sex practice among MSM.Methods A total of 420 participants were divided into three non-clinical trial groups,i.e.BCC-based condom facilitation(BCC-CF)group,sub-culture-based socio-facilitation(SBC-SF)group and the control group,to assess the sustaining effect of different models of intervention by stepwise cross-sectional follow-up survey.Results The survey of 410 MSM who had homo-sex partners in the past 6 months indicated that the rate of consistent condom use in anal intercourse with casual partners as a key indicator significantly increased in the BCC-CF(62.0%,P

Expression of HSP70 in Basal Cell Carcinoma and Squamous Cell Carcinoma / 中国医师杂志

Objective To observe the expression and role of HSP70 in human epidermis and cutaneous neoplasms.Methods 56 cases of epidermis tumors,including 29 biopsy samples from basal cell carcinoma, 27 from squamous cell carcinoma,and 30 from normal human skin were investigated. HSP70 expression was examined by immunohistochemical SABC staining with specific monoclonal antibodies.Results The expression of HSP70 was detectable in the cytoplasm throughout the epidermal cell layers in normal human epidermis,HSP70 expression in the tumor cells in basal and squamous cell carcinomas was reduced (P

Expression of Proliferatin Cell Nuclear Antigen ( PCNA ) and P53 Protein in Skin Carcinomas

Basal cell carcinoma(BCC) and squamous cell carcinoma(SCC) are the most frequent neoplasms of the human skin. Ultraviolet radiation in sunlight is a well established mutagen of p53 gene and is the major epidemiological risk factor in the development of basal cell carcinoma and squamous cell carcinoma. There is no general agreement in the several studies about the percentage of p53 positive staining of BCCs and SCCs. To evaluate the relationship between p53 positivity, PCNA index and other clinicopathological parameters, immunohistochemistry for p53 protein and PCNA was performed in 20 cases of BCCs, 14 SCCs and 3 Bowen's disease. The results are as follows; 1) The immunostaining of p53 protein and PCNA is localized to the nuclei of the tumor cells and some of adjacent normal surface squamous epithelium, more intense in the periphery of the tumor nests. 2) The pattern of immunostaining of PCNA is similar to that of p53 protein. 3) There was no difference in the expression of p53 protein according to the location of tumors, age or sex of patients, except thickness. 4) There was no difference among the BCCs, SCCs and Bowen's disease in the percentage of positive staining of p53 protein and PCNA but the aggressive BCCs and the less differentiated SCCs showed more high PCNA index and more intense p53 immunostaining. Above results suggest that the expressions of p53 protein and PCNA are related to the differentiation and biological behavior such as infiltrating property of the tumor, and they may be used as adjuvant indicators of prognosis in the skin carcinomas.

Reconstruction of a Skin Defect Following Excision of Basal Cell Carcinoma in the Nose by Labial - alar Transposition Flap / 대한피부과학회지

We report a case of nasal BCC in which the skin defect is reconstructed by a local labial-alar transposition flap. In nasal reconstruction, the local flap is the preferred methods. This flap has the advantage of a more acceptable scar, is easy to make, and less edematous than a superiorly based flap. However, for defects larger than 1cm, this flap is not advisable and the defect has to be located adjacent to th nsolabial fold.

Two Cases of Basal Cell Carcinoma Occurring on Male and Female External Genitalia / 대한피부과학회지

Basal cell carcinoma(BCC) is the most common human malignancy. It involves the face and neck most frequently. However, BCC can very rarely occur on external glenitalia such as scrotum and vulva. We report two cases of serotal and vulvar BCCs in a 67 year old imale and a 43 year old female. He suffered from well defineril erythematous to violet colored plaque with central erosion on the left scrotum for 5 years. She had a brown black colored plaque on the left vulva for 8 years. They did not show any metastatic foci from g!rimary cutaneous lesions, and underwent surgical excision and curettage respectively.