Preoperative regional infusion chemotherpy for advanced breast cancer / 中国普通外科杂志

Objective To investigate the pathological and clinical effects of preoperative intra arterial infusion chemotherapy for patients with advanced breast cancer.Methods The clinical data of 52 patients with advanced breast cancer were analyzed retrospectively.Twenty two patients were treated with preoperative intra arterial infusion chemotherapy (treatment group),and 30 were treated without preoperative intra arterial infusion chemotherapy (control group).Results In the treatment group,the tumour size reduced and symptoms relieved after intra arterial infusion chemotherapy in 86.4% of the patients.Pathological examination of the specimens showed that raryopyknosis,raryorrhexis,cytoplasm coagulation and necrosis in cancer cells around the vascular vessels were found in all patients.Interstitial edema,inflammatory cells infiltration ,fibroelastosis around the cancer cells,proliferous intima thrombus and inflammation of vessels were also found.But in the control group,the histological chang of cancer cell was not found yet.All patients were followed up for 2 to 7 years.Local recurrence rate in the treatment group was 13.6%, while that of the control group was 33.3% (P

Prevention of local recurrence of the breast cancer with intrao perative hot hypotonic solution soaking chemotherapy / 中国普通外科杂志

0.05). The rate of RCC after HHSSCT was 4.7% in study group; after second NS soaking, the rate of RCC was 19.1% in control group. The difference between the two groups was statistically significant (P

Influence of preoperative chemotherapy on telomerase activity in primary breast carcinoma / 中国普通外科杂志

Objective To explore the influence of preoperative chemotherapy (POCT) on telomerase activity(TA) of breast cancer and its mechanism. Methods TA was detected in 40 primary breast cancer specimens. Forty patients were divided into two groups: (1)POCT group. 32 patients, who underwent POCT using CMF scheme; (2) control group . 8 patients, who did not receive any POCT or radiotherapy. Results TA in POCT group(TA=0.499) was significantly lower than that in control group (TA=1.018). TA in patients received one , two or three times of POCT was 0.812,0.492 and 0.280 respectively. The difference of TA in patients received 1 time POCT and receive ≥ 2 times POCT was significant (P