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Objective To investigate the effect of Bushen Digui Decoction in treatment of chronic nephritis proteinuria of spleen kidney qi deficiency.Methods 100 patients with chronic nephritis of spleen kidney qi deficiency were randomly divided into two groups,and each group had 50 cases.The control group was given lotensin,while the study group was given Bushen Digui Decoction.The relationship between proteinuria,kidney function improving and TCM clinical signs in the two groups were observed.Results The effective rate of study group was 76.0％,which was significantly higher than that of the control group 62.0％ (P ＜ 0.05).The effective rate of the study group according to the TCM criteria was 82.0％,which was significantly higher than that of the control group 52.0％ (P ＜0.01).24h urinary protein in the control group before treatment was (1.89 ±0.87) g,after treatment for six months was (1.45 ±0.63)g,those of the study group was (1.90 ±0.86)g,(1.01 ±0.58)g.24h urine protein in beth two groups after treatment was decreased,and the difference was statistically significant (P ＜ 0.05).After treatment,the low back pain,shortness of breath,fatigue,edema,loose stools diarrhea,frequent urination,or nocturia range of TCM symptom score improvement of the study group were significantly better than control group (P ＜ 0.05),while TCM main symptoms before and after treatment showed no improvement in the control group.Before and after the treatment,the study group and the control group in the total protein content,kidney function markers (SCr,BUN,Alb and CCr content) had no significant differences (P ＞ 0.05).Conclusion Bushen Digui Decoction can significantly improve patients' kidney function and reduce proteinuria remission in patients with low back pain,shortness of breath,fatigue,swelling,loose stools diarrhea,frequent urination,or nocturia many other symptoms.
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ObJective To observe the efficay and adverse reactions of olmesartan combined with hydrochlorothiazide on patients with primary moderate hypertension,compared with the therapy of benazapril associated with amlodipine.Methods 116 primary moderate hypertension patients were randomly divided into the treatment group and control group.Patients in treatment group were treated with olmesartan combined with hydrochlorothiazide oral administration,and control group were given benazapril combined with amlodipine oral administration,which lasted for 3 weeks.Every subject was measured blood pressure before and after the drug administration and observed adverse reaction.Cardiac hypertrophy was detected by UCG.A comparison was made in effectiveness of the drug and cardiac hypertrophy between two groups.Results There was significant difference in effectiveness of two anti-hypertension therapies,and cardiac hypertrophy in the treatment group was lighter than that in control group.Conclusion The therapy of olmesartan combined with hydrochlorothiazide was more effective than that of benazapril combined with amlodipine,also more depressed cardiac hypertrophy.
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Objective To explore the effect of benazepril combined with amoldipin on cardiac function and urine microalbuminuria in patients with moderate and severe primary hypertensive left ventricular hypertrophy.Methods 90 patients with mild to moderate essential hypertension and left ventficular hypertrophy were randomly divided into three groups(n=30 in each group),who were treated with benazepril,amoldinpin and benazepril com-bined with amoldipin,respectively.Blood pressure was monitored and left ventricular diameter(LVDd),interven-tricular septal thick(IVS),left ventricular posterior wall(LVPW),left ventricular masses index(LVMI)were measured by echocardiography before and after treatment in three groups.Microalbuminuria,serum nitrogen and creatinine were examined at the same time.Results Both SBP and DSP were significantly decreased in three groups after two weeks treatment.E/A ratio and EF were increased at the same time(P<0.01).After treatment,these changes were more significant in Benazepril with Amlodipine group(P<0.05).After 24 week treatment IVS,LVPW and LVMI were significantly dereased(P<0.01),while LVEF and E/A increased(P<0.01).After 4-week treatment,microalbuminuria was decreased in three groups,especially in combined treatment group(P<0.01).With the time of medication in combined treatment group,microalbuminuria was increasingly decreased which was significant in benazepril and amoldipin group after 24 weeks(P<0.01).Conclusion The Benzazepril with am-lodipine are more effective in lowering blood pressure,left ventricular hypertrophy and decrease microalbuminuria.
RESUMO
Objective To explore the effect of benazepril combined with amoldipin on cardiac function and urine microalbuminuria in patients with moderate and severe primary hypertensive left ventricular hypertrophy.Methods 90 patients with mild to moderate essential hypertension and left ventficular hypertrophy were randomly divided into three groups(n=30 in each group),who were treated with benazepril,amoldinpin and benazepril com-bined with amoldipin,respectively.Blood pressure was monitored and left ventricular diameter(LVDd),interven-tricular septal thick(IVS),left ventricular posterior wall(LVPW),left ventricular masses index(LVMI)were measured by echocardiography before and after treatment in three groups.Microalbuminuria,serum nitrogen and creatinine were examined at the same time.Results Both SBP and DSP were significantly decreased in three groups after two weeks treatment.E/A ratio and EF were increased at the same time(P<0.01).After treatment,these changes were more significant in Benazepril with Amlodipine group(P<0.05).After 24 week treatment IVS,LVPW and LVMI were significantly dereased(P<0.01),while LVEF and E/A increased(P<0.01).After 4-week treatment,microalbuminuria was decreased in three groups,especially in combined treatment group(P<0.01).With the time of medication in combined treatment group,microalbuminuria was increasingly decreased which was significant in benazepril and amoldipin group after 24 weeks(P<0.01).Conclusion The Benzazepril with am-lodipine are more effective in lowering blood pressure,left ventricular hypertrophy and decrease microalbuminuria.