Asymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count

Abstract In HIV-patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to AIDS and non-AIDS comorbidities, even during combined antiretroviral therapy (cART). In this cross-sectional study, we aimed to analyze some of these parameters in 138 different asymptomatic HIV-infected patients, doing multiple comparisons between the groups, which are dichotomized in the presence / absence of cART and type of immune response (immunological responders [iR,>500cells/mL] or non-responders [iNR,<500cells/ mL]). Were analyzed cytokines and other routine laboratory parameters. Our results showed high creatine phosphokinase and low IL-10 levels in cART-patients. They also presented metabolic alterations, including elevations in total cholesterol and triglycerides, particularly in those iNR. In ART-iR an increased alanine aminotransferase was observed. Those NAÏVE-iNR presented high LDL-cholesterol, C-reactive protein and lactate dehydrogenase values. The long-term non-progressors (LTNP) showed the best laboratory results. In conclusion, many blood parameters were changed in HIV-patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early therapeutic onset.

How I am, how am I: nutritional status and body image in women submitted to aesthetic plastic surgery / Como Sou, como Estou: estado nutricional e imagem corporal em mulheres submetidas à cirurgia plástica estética / Como Soy, como Estoy: estado nutricional e imagen corporal en mujeres sometidas a cirurgia plastica estetica

Aesthetic Plastic Surgery (APS) has grown dramatically around the world, especially in Brazil. Women were more dissatisfied with their appearance compared to men, and this is the main predictor for the search of APS. We investigated the body image (BI) and nutritional status (NS) of 40 adult women requesting APS - Clinical Group (G1, n = 20) - and 20 not requesting APS - Comparative Group (G2) - with similar age and socio-educational characteristics. We evaluated the biochemistry of blood, the BMI, and the percentage of body fat, with a statistically significant difference between G1 and G2 (p < 0.01). G1 showed a higher prevalence of overweight/obesity, dissatisfaction with the overall appearance (p = 0.04) in the Body-Self-Relationships Questionnaire, concern with BMI (p = 0.04), and major investment in appearance (p = 0.04). Due to these potential indicators of mental health problems, psychological and nutritional monitoring is essential to prevent poor progression in APS.

Cirurgia Plástica Estética (CPE) cresceu drasticamente no mundo, especialmente no Brasil. Mulheres mostraram-se mais insatisfeitas com a aparência em relação aos homens, e esse é o principal preditor para a busca da CPE. Investigou-se a Imagem Corporal (IC) e o Estado Nutricional (EN) de 40 mulheres adultas solicitantes de CPE - Grupo Clínico (G1, n = 20) - e 20 não solicitantes de CPE - Grupo de Comparação (G2) - de características etárias e socioeducacionais semelhantes. Avaliaram-se a bioquímica do sangue, o IMC e a porcentagem de gordura corporal com diferenças estatísticas significativas entre G1 e G2 (p < 0, 01). O G1 apresentou maior prevalência de sobrepeso/obesidade, insatisfação com a aparência geral (p = 0,04) no Body-Self-Relationships Questionnaire, grande preocupação com o IMC (p = 0,04) e grande investimento na aparência (p = 0,04). Em função desses potenciais indicadores de problemas de saúde mental, o monitoramento psicológico e nutricional é essencial para prevenir uma evolução negativa em CPE.

Cirugía Plástica Estética (CPE) creció drásticamente en Brasil y en el mundo. Mujeres se mostraron más insatisfechas con la apariencia que los hombres, siendo éste el principal predictor de búsqueda por CPE. Se ha investigado la imagen corporal (IC) y el estado nutricional (EN) de 40 mujeres adultas solicitantes de CPE - Grupo Clínico (G1, n = 20) - y 20 que no solicitó CPE - Grupo de Comparación (G2) - de características de edad e socioeducativa similares. Se evaluó la bioquímica de la sangre, el IMC y el % de grasa con diferencias significativas entre G1 y G2 (p < 0, 01). G1 mostró mayor prevalencia de sobrepeso/obesidad, insatisfacción con la apariencia (p = 0.04) en el Body-Self-Relationships Questionnaire, preocupación por el IMC (p = 0.04) y mayor investidura en apariencia (p = 0.04). Debido a estos indicadores potenciales de problemas de salud mental, el monitoreo psicológico y nutricional es esencial para prevenir la mala progresión en CPE.