To explore the serum level of transforming growth factor-β1 ( TGF-β1 ) in patients with prehypertension and impaired fasting blood glucose / 中国医师杂志

Objective To explore the level of serum transforming growth factor-β1 (TGF-β1) in patients with prehypertension and impaired fasting blood glucose.Methods A total of 180 healthy subjects with matched age and sex was divided into 3 groups:group A (blood pressure ＜ 120/80 mmHg and fasting blood glucose ＜6.1 mmoVL),group B (prehypertension and fasting blood glucose ＜6.1 mmol/L),group C (prehypertension and 6.1 mmol/L≤ fasting blood glucose ≤7.0 mmol/L).There were 60 subjects in every group.Serum TGF-β1 was measured by Enzyme-Linked Immunosobent Assay (ELISA),fasting blood glucose,triglyceride,total cholesterol,low-density lipoprotein cholesterol ( LDL-C),high-density lipoprotein cholesterol ( HDL-C),Uric Acid ( UA),body mass index (BMI) were determined.Results The level of serum TGF-β1 in group B and C was higher in that in group A( t =2.071,and 2.147,P ＜0.05 ).The level of serum TGF-β1 was higher in group C than group B,but no significant difference was observed ( P ＞0.05).The pearson correlation analysis showed there was a significant correlation between TGF-β1 and systolic blood pressure ( r =0.279,P =0.047).Conclusions The level of serum TGF-β1 was higher in patients with prehypertention which may mediate the target organ damage caused by the prehypertention.

Efeitos do uso de manjericão (Ocimum basilicum L) no perfil bioquímico de ratos Wistar / Effects of the use of basil (Ocimum basilicum L) in biochemical profile of Wistar rats

Objetivo - O manjericão (Ocimum basilicum L.) é uma planta comumente utilizada na culinária e tem sido apontado pelas suas propriedades benéficas à saúde, possuindo importantes efeitos antioxidantes, anti-inflamatórios e hepato-protetores. O objetivo deste trabalho foi avaliar os efeitos da administração de manjericão (Ocimum basilicum L.) no perfil bioquímico de ratos. Método - Trinta ratos machos da linhagem Wistar foram utilizados. Os ratos foram divididos aleatoriamente em três grupos de 10 animais e receberam tratamentos ad libitum por um período de trinta dias. O primeiro grupo (G1) recebeu água ad libitum, o segundo e terceiro grupos (G2 e G3) receberam infusão de manjericão nas concentrações de 20g/L e 40g/L, respectivamente. Foram feitas análises de glicemia, colesterol total, HDL-c, triglicerídeos, proteína C reativa (PCR), creatinina, aspartato aminotransferase (AST) e alanina aminotransferase (ALT). Resultados - A utilização do Ocimum basilicum L. promoveu redução de 37,44% no índice de colesterol total e de 34,55% nos níveis de triglicerídeos, e aumento de 39% nos níveis de HDL-c em relação ao grupo controle. Considerando a glicemia houve redução de 11,40% e 19,36% utilizando concentrações de 20 g/L e 40 g/L do manjericão, respectivamente. Não houve alteração significativa nos níveis de creatinina, PCR e enzimas hepáticas. Conclusão - Os resultados sobre as variáveis bioquímicas são promissores, visto que as alterações podem beneficiar indivíduos em condições de hipercolesterolemia e hiperglicemia, auxiliando na prevenção e tratamento de distúrbios crônico-degenerativos. Sugere-se que novos estudos sejam realizados, como a análise de toxicidade da infusão de manjericão em ratos Wistar e determinação dos constituintes químicos da infusão.

Objective - Basil (Ocimum basilicum L.) is a plant commonly used in culinary and it has been indicated for their beneficial health properties, such as significant antioxidant, anti-inflammatory and hepato-protective effects. The aim of this study was to evaluate the effects of basil (Ocimum basilicum L.) by oral administration in the biochemical profile of rats. Method - Thirty male Wistar rats were randomly divided in three groups of 10 animals, and were fed ad libitum for 30 days. The first group (G1) received water ad libitum, the second and third groups (G2 and G3) received an infusion of basil at concentrations of 20 g/L and 40 g/L, respectively. Levels of glucose, total cholesterol, HDL-C, triglycerides, C-reactive protein (CRP), creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed. Results - The use of O. basilicum L. decreased 37.44% in cholesterol levels and 34.55% in triglyceride levels, and increased 39.00% in HDL-c levels. Whereas the blood glycemic decreased 11.40% and 19.36% using concentrations of 20g/L and 40g/L of basil, respectively. There was no significant modification in creatinine levels, CRP and liver enzymes. Conclusion - The results show that O. basilicum L. can be helpful to prevent hyperglycemia and dyslipidemias but further studies should be done, such as the toxic analysis of basil infusion in male Wistar rats and the determination of the chemical constituents of the infusion.

INFLUENCE OF RUNNING SPEED AND EXERCISE DURATION ON BLOOD GLUCOSE THRESHOLD DURING LONG-DISTANCE RUNNING / 体力科学

This study was intended to clarify 1) the difference of the exercise intensity at blood lactate threshold (LT) and blood glucose threshold (GT), 2) the effect of exercise duration on the LT and GT during two sets of incremental running test. Ten male runners (age 25.0±3.2 yr, height 171.2±5.5 cm, body mass 57.9±4.0 kg, VO_2max 64.6±3.0 ml/kg/min) completed two sets of incremental running test (each set was set to run ten stages at 60-90% VO_2max). Second set was repeated after 8 min recovery. LT and GT speed were investigated at the first set. Lactate minimum (LM) and glucose minimum (GM) speed were selected where the blood lactate and glucose concentration were at the lowest during the second set. Using the indirect calorimetry (VO₂, VCO₂), fat and carbohydrate oxidation rates were calculated. GT was observed in all runners. VO₂ and energy expenditure were similar between the two incremental running tests, however, fat oxidation was significantly higher and carbohydrate oxidation was significantly lower during the first half of the second set. This change was regarded as the influence of the exercise duration in the first set. Furthermore, GM speed was significantly lower than GT speed, but LM speed and LT speed were not different. It was considered that the shift of GT was affected by the substrate utilization change during prolonged exercise.