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Objective:To analyze the adverse reactions, cosmetic effects and the improvement in positioning of breast cancer patients who received breast-conserving operation followed by hypofractionated radiotherapy and conventional radiotherapy based on the positioning of body membrane method with windowing method.Methods:From January 2019 to April 2020, 75 patients with breast cancer were randomly divided into two groups: hypofractionated radiotherapy (38 cases) administered with 42.4 Gy/16 fractions (2.65 Gy/fraction), and conventional group (37 cases) with 50 Gy/25 fractions (2.0 Gy/fraction). All of them were located by thermoplastic film, and the upper parts of the thermoplastic film were cut along the root of the breast. The adverse reactions, cosmetic effect and follow-up survival of the two groups were observed.Results:During the follow-up period, there was no recurrence in the two groups within 8 months. The local control rate and the survival rate of all the patients were both 100%. The total incidence of acute skin reaction in the two groups was 36.84% (14/38) in the hypofractionated group and 67.57% (25/37) in the conventional group ( χ2=7.09, P<0.05). The excellent and good rate of cosmetic effect was 89.47% (34/38) in the hypofractionated group and 78.38% (29/37) in the conventional group, but the difference was not statistically significant ( P>0.05). There were not statistically differences in the late skin reaction, leucopenia and thrombocytopenia between the two groups ( P>0.05). Conclusions:Breast-conserving surgery followed by hypofractionated radiotherapy with the positioning of body membrane windowing localization method is feasible and safe. Also, it can significantly reduce the acute radiation skin reactions. But the long-term effects still need to be confirmed by long-term follow-up.
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Objective To investigate the clinical value of negative pressure vacuum cushion combined with thermoplastic body membrane in radiotherapy for Wilms tumor in children.Methods A total of 42 pediatric patients with Wilms tumor who received radiotherapy after surgery were enrolled in the study and were randomly divided into two groups according to the fixation positions:group A and group B.During radiotherapy, the patients in group A were fixed with negative pressure vacuum cushion, and those in group B were fixed by negative pressure vacuum cushion combined with thermoplastic body membrane.The setup errors, short-term effects, adverse reactions, and prognosis were compared between the two groups.ResultsGroup B showed significantly lower translational errors and rotational errors, as well as significantly higher rates of ≤3 mm and ≤5 mm errors, compared with the group A (P=0.04,0.04,0.04,0.03,0.00,0.04,0.04,0.00,0.04).Group B also showed significantly higher complete remission rates and response rates than group A (P=0.02,0.04).There were no significant differences in the adverse reaction rates (P=0.75) and the overall survival (OS) rates at 2 and 3 years (P=0.68,0.74) between the two groups.Group A had the MPTV values in left-right (LR) direction (x-axis), superior-inferior (SI) direction (y-axis), and anterior-posterior (AP) direction (z-axis) being 5.74 mm, 5.93 mm, and 5.94 mm, respectively, and group B had the MPTV values at LR, SI, and AP directions being 4.21 mm, 5.71 mm, and 4.61 mm, respectively.Conclusions In the radiotherapy positioning for Wilms tumor in children, fixation limbs with negative pressure vacuum cushion combined with thermoplastic body membrane effectively reduces the setup errors and improves the effect of radiotherapy, so it holds promise for clinical application.
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Objective To study the set-up accuracy in radiotherapy of thoracic neoplasms by improving the body immobilization method.Methods Fifty patients with thoracic neoplasms were randomly divided into conventional group (without electrode paste) and improved group (with electrode paste).Using simulator for position calibration and center field digital image reconstruction from treatment planning system.Then compare the set-up accuracy of two groups with different body methods by grouped t-test.Results Set-up error in the left-right,superior-inferior,anterior-posterior direction were 2.5 ± 1.5 and 2.4 ± 1.4(P =0.010),4.4 ± 2.0 and 2.2 ± 1.2 (P =0.000),2.2 ± 1.3 and 2.1 ± 1.0 (P =0.100) in conventional group and improved group,respectively.Conclusions The improved body immobilization method improves setup accuracy in radiotherapy for thoracic neoplasms which also will be effective for clinical treatment.