Comparison of ostene and bone wax on bone healing: a comparative experimental study in rabbits

Introduction: Ostene is a new synthetic bone hemostatic wax-like inert and biocompatible material that dissolves within two days after application. bone wax is a well- known topical hemostatic agent, easy to use, and its application is very simple. wound healing is a complex biological process; bone is a dynamic tissue that is continuously resorbed, renewed, and remodeled. materials and methods: twenty domestic rabbits were divided into four groups (day 1, day 3, day 7, and day 14). each rabbit was anaesthetized and three holes were drilled in the mandible: one was filled with Ostene, another with bone wax, and the other was left unfilled as control. sites of intervention were assessed by histopathology. results and Discussion: Ostene and bone wax showed osteoinductive property in bone healing with no inflammatory reaction. our study revealed new bone formation within 14 days in Ostene group. after histopathological analysis and scoring was finished, analysis by SPSS 14 software showed a significant difference between the use of Ostene and bone wax. conclusion: Ostene showed superiority over bone wax in bone healing, and it can be used in the same way as bone wax with no interference with bone healing and osteogenesis. Ostene has no side effects following application.

Necessity of Bone Wax Stanching Bleeding at Sternal Edge in Patients With Cardiac Surgery by Median Sternotomy / 中国循环杂志

Objective: To explore the necessity for application of bone wax stanching bleeding at sternal edge in cardiac surgery by median sternotomy. Methods: A total of 445 patients who receive cardiac surgery by the same surgeon performing median sternotomy in our hospital from 2011-01 to 2014-12 were studied. According to application of bone wax stanching bleeding, the patients were divided into 2 groups: Bone wax group,n=210 and Non-bone wax group,n=235. Re-thoracotomy for hemostasis, 12 h, 24 h and total draining volume after the operation and time of closing incision were compared between 2 groups. Results: There were 2 patients and 1 patient received re-thoracotomy for hemostasis in Bone wax group and Non-bone wax group respectively, which was not related to bone marrow cavity bleeding. In Bone wax group and Non-bone wax group, the draining volume at 12 h post-operation were (451 ± 240) ml vs (483 ± 238) ml, at 24 h post-operation were (615 ± 304) ml vs (639 ± 285) ml and the total volume were (842 ± 467) ml vs (842 ± 364) ml, allP>0.05; the time of closing incision were (68.0 ± 23.0 ) min vs (66.0 ± 19.0 ) min,P>0.05; the total transfusion rates were 21% vs 19%,P>0.05. Conclusion: Application of bone wax at sternum edge could neither affecting the drainage nor the speed of closing incision in cardiac surgery and therefore, it might be given up.

Granuloma formation and loss of tooth vitality following the use of bone wax in third molar surgery: report of a case

In the present case, granuloma formation and loss of tooth vitality following the use of bone wax in third molar surgery in a 16-year-old male patient were reported. Endodontic and surgical treatments were carried out on the patient. As foreign body granulomatous reaction to bone wax is not uncommon in the literature review, alternative haemostatic agents should be taken into consideration to avoid any potential complications and untoward effects of using bone wax for haemorrhage control in surgical procedures.

Benign Mass after Reduction Mandibular Angleplasty

There have been various methods of reduction mandibular angleplasty. 21-year old woman with prominent mandibular angle and body was done curved angle ostectomy with tangential ostectomy. In operation, we had used bone wax for controlling of bone bleeding. After 1 year, the patient revisited to our clinic because she had a mass with tenderness on Lt. mandibular angle area. The mass had been gradually increasing in severity after reduction mandibular angleplasty. Computed tomography of the patient showed inflammatory lesion in Lt. mandibular angle area with focal cortical bony destruction and adjacent soft tissue thickening. After surgical removal of mass, clinical pathology revealed that the mass was chronic inflammatory fibrosis around foreign body(bone wax). The postoperative course was uneventful, the patient was satisfied for her shape. If possible we must avoid using a bone wax in reduction mandibular angleplasty, because bone wax can induce inflammatory reaction and fibrosis.

Effect of the Bone wax for the Maintenance of a Created Fistula between the Maxillary Sinus and the Nasal Cavity in Rabbits

PURPOSE: To investigate whether the bone wax could maintain the created fistula between the maxillary sinus and the nasal cavity in a rabbit model of dacryocystorhinostomy. METHODS: After creating a fistula between the maxillary sinus and the nasal cavity at both sides in 20 rabbits, the one on the right side was plugged with bone wax (treated side) and the one on the left side was used as a control. Five rabbits were sacrificed each time at 1, 2, 4 weeks after surgery. Bone wax was removed at 4weeks after surgery in 5 rabbits and they were sacrificed 2 weeks later. The state of the fistulas and the histopathology were observed. RESULTS: Among controls, only one of the rabbits sacrificed at 1 and 2 weeks after surgery, showed partially open fistula and all other rabbits showed closure of fistula. The treated fistulas were opened in 4 rabbits at 1 week, in 3 rabbits at 2 weeks, and 4 rabbits at 4weeks after surgery. Two out of 5 treated fistulas which had the removal of the bone wax 4 weeks later showed open fistula. The epithelial lining of the opened treated fistula was observed at 4 weeks after surgery. There was no significant difference in the amount of discharge within the maxillary sinus or the degree of inflammation around the fistula between the treated and the control sides. CONCLUSIONS: The bone wax may be used as a new stent in maintaining a created fistula during dacryocystorhinostomy.

Evaluation on Biological Compatibility and Hemostatic Effect of Sterilized Medical Bone Wax on Bone Wound / 中国药房

OBJECTIVE:To evaluate the biological compatibility and clinical therapeutic effect of the medical sterilized bone wax.METHODS:Embedding test and pathological test as well as hemolytic test were performed by using rabbits as test animal.12531case-times were investigated in respect to the therapeutic effect,prognosis and satisfactory rate.RESULTS:The embedded bone wax was coated by connective tissue and has not been absorbed without surrounding inflammation,edema or necrosis.The bone wax could not be absorbed after stanching bleeding of the bone broken surface.No hemolytic phenomena were observed.The wound healing obtained a satisfactory rate of99.1%.CONCLUSION:The sterilized medical bone wax has good biological compatibility and is safe and effective to stanch bleeding.It is convenient to use due to its singer dose sterilized packaging.

Preparation and Clinical Observation of Sterilized Medical Bone Wax / 中国药房

OBJECTIVE:To prepare the sterilized medical bone wax and to establish the standard of quality control.METHODS:The bone wax was identified with chemical approach and the quality of bone wax was evaluated by saponification value.RESULTS:The bone wax was appropriate in formula,feasible in preparing technique and satisfactory in therapeutic efficacy with a satisfication rate of 98%.CONCLUSION:There are no obvious differences between the bone wax developed by our hospital and imported bone wax in quality,therefore the prepared bone wax can take the place of imported products.