Actividad expectorante y toxicológica de una formulación elaborada a partir de Eucalyptus globulus Labill, Borago officinalis L, Y Sambucus Nigra L / Expectorant and toxicological activity of a formulation made from Eucalyptus globulus Labill, Borago officinalis L., and Sambucus Nigra L

Introducción: Eucalyptus globulus Labill., (eucalipto), Borago officinalis L. (Borraja) y Sambucus nigra L. (saúco) son especies vegetales de amplio uso popular por sus propiedades antitusígenas y mucolíticas. Objetivo: evaluar los efectos farmacológico y toxicológico de un fitofármaco elaborado con el extracto de la mezcla de las tres plantas. Métodos: a partir de las hojas secas de cada especie, se elaboraron dos extractos fluidos de las tres plantas: E. globulus B. officinalis y S nigra, mezcladas en proporción 25:25:50, respectivamente, se empleó el método de percolación y como disolventes etanol de concentraciones al 30 y 70 por ciento. Para la evaluación del efecto mucolítico se empleó el modelo de Rojo Fenol en secreciones de ratón y se ensayaron los extractos de concentraciones alcohólicas al 30 y 70 por ciento. El estudio toxicológico se realizó al extracto de concentración alcohólica al 70 por ciento. Resultados: en la evaluación farmacológica se encontró que los extractos hidroalcohólicos al 30 y 70 por ciento presentaron efecto mucolítico, con una efectividad ligeramente superior para el extracto en alcohol al 70 por ciento. Cuando se evaluó toxicológicamente, este extracto no presentó efecto tóxico en el ensayo de toxicidad aguda a dosis límite. Conclusiones: las formulaciones elaboradas con los extractos fluidos de las plantas empleando etanol al 30 y 70 por ciento, mostraron efecto mucolítico en el modelo de rojo fenol en secreciones de ratón y con las condiciones experimentales del estudio. El extracto de las plantas en etanol al 70 por ciento no presentó efecto tóxico en el ensayo de toxicidad aguda a dosis límite(AU)

Introduction: Eucalyptus globulus Labill. (eucalyptus), Borago officinalis L. (borage) and Sambucus nigra L. (elder) are plant species commonly used in folk medicine for their antitussive and mucolytic properties. Objective: Evaluate the pharmacological and toxicological effects of a drug made with an extract obtained from a mixture of the three plants. Methods: Two fluid extracts were obtained from dry leaves of the three species, E. globulus, B. officinalis and S. nigra, mixed in a 25:25:50 proportion. The method used was percolation and the solvents were 30 percent and 70 percent ethanol. The mucolytic effect was evaluated with the phenol red model in mouse secretions, and assays were conducted of the 30 percent and 70 percent alcoholic extracts. Toxicological analysis was performed on the 70 percent alcoholic extract. Results: Pharmacological evaluation found that 30 percent and 70 percent hydroalcoholic extracts display a mucolytic effect, effectiveness being slightly higher in the 70 percent alcoholic extract. When evaluated toxicologically, this extract did not show any toxic effect in the dose-limiting acute toxicity test. Conclusions: The formulations developed with fluid plant extracts using 30 percent and 70 percent ethanol were found to have a mucolytic effect in the red phenol model in mouse secretions under experimental test conditions. The 70 percent ethanolic plant extract did not have a toxic effect in the dose-limiting acute toxicity tes(AU)

Mastalgia cíclica: abordagem clínica / Cyclic mastalgia: clinical approach

A mastalgia é uma queixa comum nos consultórios de mastologia. Devido à intensidade da dorou pelo medo do câncer de mama, mulheres com mastalgia buscam orientação com o mastologista.Nesse sentido, o mastologista deve estar familiarizado com o tema. Considerando que aqueixa de dor mamária está entre as mais frequentes em mastologia, conduziu-se uma revisão daliteratura, enfatizando-se a abordagem terapêutica da mastalgia.

Mastalgia is a common complaint in mastology offices. Women who are experiencing mastalgia seekclarification with the breast cancer specialist due to the intensity of the pain or because they fear breastcancer. Therefore, the specialist shall understand such issue. Considering that the complaint concerningbreast pain is one of the most frequent complaints in mastology, a literature review was carried outemphasizing the therapeutic approach of mastalgia.