RESUMO
Objective To investigate the clinical effect of progesterone soft capsules combined with Bushenantai recipe in the treatment of anticardiolipin antibody positive recurrent abortion.Methods 98 patients with positive anticardiolipin antibody and recurrent spontaneous abortion were selected,and they were randomly divided into observation group and control group according to the digital table,49 cases in each group.The control group was given progesterone soft capsules treatment,the observation group was given the combined treatment of Bushenantai recipe and progesterone soft capsules.The medication time,live birth rate and antibody clearance rate were compared between the two groups.Results The treatment time of the observation group was (179.5 ± 12.8) d,which was significantly shorter than (288.6 ± 14.5)d of the control group,the difference was statistically significant(t =6.249,P ＜0.05).The live birth rate,antibody clearance rate of the observation group were 91.8％,79.6％,respectively,which were significantly higher than those of the control group (79.6％,36.7％),the differences were statistically significant(x2 =5.247,4.998,all P ＜ 0.05).The observation group had 3 cases of adverse reactions (6.0％),the control group had 15 cases of adverse reactions (30.6％),the incidence rate of adverse reactions between the two groups had statistically significant difference (x2 =8.250,P ＜ 0.05).Conclusion Progesterone soft capsules combined with Bushenantai recipe in the treatment of anticardiolipin antibody positive patients with recurrent spontaneous abortion can shorten the treatment time,improve pregnancy outcome,improve the antibody clearance rate.
RESUMO
In order to observe the effect of Bushenantai recipe on the expression of endometrial leukemia-inhibitory factor (LIF) in mice with embryonic implantation dysfunction (EID), 120 Kun- ruing mice post coition were randomized into three groups: normal control group, model group and traditional Chinese medicine group (TCM group) (n=40 in each group). Uterus was collected on the pregnancy day (Pd) 4, 5, 6 after an intravenous injection of Evan's blue. The endometrium was dyed by Evan's blue and the mean points of response were observed on Pd 5. The expression of LIF mRNA and protein was detected by RT-PCR and immunohistochemistry respectively and analyzed statistically by image system. The results showed that the number of implantation sites in model group was remarkably less than in normal control group and TCM group. There was no significant difference between normal control group and TCM group. The expression of L1F mRNA and protein in model group was delayed. Bushenantai recipe could increase the expression of LIF mRNA and protein in endometria of mice with EID. It was suggested that Bushenantai recipe could improve em- bryo implantation of mice with EID by promoting the endometrial LIF expression and endometrial decidualization.