RESUMO
OBJECTIVE: To probe into the overall situation about the study on compatible stability of drugs. METHODS: The compatible stability of drugs reported in a total of 113 articles in 2005 in 52 kinds of periodicals were retrieved from CHKD and summarized analytically. RESULTS: The drug categories involved were chiefly antibiotics (59%), Chinese traditional medicines or Chinese drug components (20%) and other drugs (21%). Quantitative analyses in 91 articles were chiefly conducted by ultraviolet spectrophotometry (79%) or HPLC (20%). CONCLUSION: Because the ultraviolet spectrophotometry was greatly used and some experimental designs were not well-knit enough, the reliability of experimental results of compatible stability of drugs might be seriously affected, which poses a great danger to the clinical compatible use of drugs.