Seven cases of toxic encephalopathy associated with diquat poisoning / 中华急诊医学杂志

Objective:To improve the understanding of the clinical features of toxic encephalopathy associated with diquat poisoning.Methods:This study collected and analyzed the diagnosis and treatment process of 7 patients with acute diquat poisoning combined with central nervous system complications admitted to the First Affiliated Hospital of Zhengzhou University from April 2021 to April 2022. "Diquat" and "Poisoning" were used as keywords to search in CNKI, Wanfang database and PubMed database, and the literature of previous cases was reviewed for summary analysis.Results:Among the 7 patients in our hospital, there were 2 males and 5 females, with an average age of 31 years (range14-57) and an average dose of 23.14 g [(10-40)g]. During the treatment, 3 patients developed irritability and convulsions, 3 patients occurred coma, and one had generalized tonic-clonic seizures. Four patients died and 3 survived, of which 2 patients returned to normal life and study, and one remained abnormal mental behavior (currently in long-term follow-up). All three survivors developed neurological symptoms later than those who died, and were awake about 30 days after taking the drug.Conclusions:Toxic encephalopathy associated with diquat poisoning has rapid progression, poor prognosis and high mortality. This study found that the survival rate of patients with > 48 h of first onset of neurological symptoms is much higher than that of patients with ≤ 48 h of first onset of neurological symptoms, while sex, age, estimated oral dose, and type of presentation of neurological symptoms for the first time have little effect on the survival rate of hospital discharge. The earlier neurological symptoms appear, the greater the likelihood of a poor prognosis.

Influences of Cell-ECM Adhesion on Migration of Tumor Cells Regulated by ECM Stiffness: A Model Study / 医用生物力学

Objective To study the influence of cell-extracellular matrix (ECM) adhesion on migration of tumor cells regulated by ECM stiffness. Methods The cellular Potts model (CPM) was established to simulate tumor cell growth and cellular immune feedback system. The effects from mechanical behavior of cells on cell-ECM adhesion were observed, and the migration of tumor cells under different ECM was analyzed. Results The ECM stiffness could influence the migration rate of tumor cells. The change of ECM stiffness regulated the adhesion force between cells and ECM, and the change of adhesion force would influence the migration rate of cells. Conclusions The migration and distribution patterns of cells are closely related to the adhesion and stiffness of ECM. The increase in ECM stiffness can effectively promote the migration rate of tumor cells, and the further increase in ECM stiffness inhibits the migration of tumor cells. These findings may further reveal dynamic changes of ECM, adhesion and mechanical performance of tumor cell migration.

Effects of Intercellular Adhesion of Tumor on Immune Escape / 医用生物力学

Objective To study the effect of intercellular adhesion of tumor cells on immune response of human body. Methods A tumor growth-cellular immune feedback model was developed based on cellular Potts model (CPM) to simulate the progression of tumor cells and the cellular immune feedback system, and the influence of adhesion between tumor cells on the immune system was analyzed. Results Under the condition of tumor intercellular adhesion with normal intensity, tumor cells could escape when the immune system was weak and be eliminated when the immune system was strong. Under the condition of tumor intercellular adhesion with low intensity, tumor cells could escape when the immune system was weak, while exhibited behavior of oscillation and could not be eliminated when the immune system was strong. Conclusions Higher adhesion between tumor cells inhibited escape of tumor cells from the immune system, while lower adhesion between tumor cells could effectively help the tumor escape killing from the immune system. When the tumor was extremely spread, the immune system could not completely eliminate tumor cells.

Research on differentiated marketing strategy of ASEAN market for development of Chinese patent medicine based on principal component analysis and hierarchical clustering method / 中草药

With high-tech, high added-value, and independent intellectual property rights, Chinese patent medicine (CPM) is one of the most important exporting categories in Chinese materia medica (CMM), and its overseas development has become an important symbol of international recognition for CMM. With the implementation of the Belt and Road Initiative and the acceleration of bilateral economic integration, CMM trade between China and Association of Southeast Asian Nations (ASEAN) is facing with great potential and opportunities. ASEAN market is bound to be a vital breakthrough in the globalization of CPM and has strategic significance for its transnational operation. Since ten member countries of ASEAN have obvious differences in their economic development, market size, and medical and health levels, this paper aims to establish evaluation index system, further subdivide the ASEAN market by means of principal component analysis and hierarchical clustering method, and put forward different marketing strategies for each segmented markets including developed market, emerging market, potential market, and secondary market, hoping to provide useful advice and reference for the globalization of CPM in ASEAN or even in European and American main market.

Early efficacy comparison between independent exercises under the doctors guidance and passive exercises by using CPM in rehabilitation after TKA / 实用医学杂志

Objective To compare the early efficacy of two different ways of rehabilitation exercises in total knee arthroplasty (TKA) patients. Method From January 2011 to January 2014,136 patients having undergone TKA were randomly divided into two groups. In group A , patients exercised under the guidance with doctor. In group B, patients exercised by using continuous passive movement (CPM) machine. Compared the data from the two groups including range of motion (ROM) of the knee joint, knee function score (KFS) and circumference of the knee joint, t test of independent sample was utilized in the research. Results All patientswere followed up in 4 weeks. The ROM and KFS of Group A was significantly better than Group B (P 0.05).Conclusion Group A and B are effective methods in TKA patients in early rehabilitation training. But training under the guidance of doctor has greater advantages than CPM.

Application of PERT/CPM in dental practice / 대한치과보철학회지

PURPOSE: Process management is the activity which manages all procedure of construction by representing visually interrelation of operation or sequence setting. The purpose of this study was for reducing treatment period and higher efficiency of treatment through application of PERT/CPM (Program Evaluation & Review Technique/Critical Path Method) in dental clinic. MATERIALS AND METHODS: The patients were selected for study who needed more than 2 departments' cooperation for prosthodontic treatment in Wonkwang Dental University Hospital. Control group is composed of the patient's whole treatment plan, treatment period, numbers of hospital visit, treatment costs, treatment results. On the other hand, experiment group contains the patient's virtual treatment data based on PERT/CPM technique. We applied PERT/CPM in operation analysis. RESULTS: Treatment period, numbers of hospital visit was decreased as 18.1% and 15.3% when we applied operation analysis based on charts. Also treatment cost in experiment group was 0.9% economized compared with control group's treatment cost. CONCLUSION: Application of PERT/CPM in dental clinic can achieve reliable treatment and reduced treatment period and establish plan of minimum treatment cost.

Evaluación de la citotoxicidad de distintos cementos selladores endodónticos en cultivos de fibroblastos gingivales / Citotoxicity assessment of different endodontic-use sealing cements in gingival fibroblast cultures

El objetivo de esta investigación fue evaluar in vitro la respuesta de fibroblastos gingivales contra diferentes selladores endodónticos mediante cultivos celulares, en un lapso de 96 horas. Los resultados obtenidos a intervalos de tiempo de 0, 1, 2, 3, 6, 24, 48, 72 y 96 horas fueron utilizados para determinar la citotoxicidad de los selladores. Cultivos de fibroblastos gingivales sin ningún sellador y con Sealapex fueron utilizados como controles positivos y negativos respectivamente. Los resultados fueron comparados con los controles negativos y analizados estadísticamente por medio de la prueba t Dunnett (p ≤ 0.05). Los cementos selladores investigados fueron: ProRoot MTA gris y blanco CPM, MTA Angelus, Sealapex y GuttaFlow. Los resultados demostraron que a pesar de que el ProRoot MTA (gris y blanco) MTA Angelus, CPM y GuttaFlow demostraron tener un potencial citotóxico menor que el Sealapex, no se encontraron diferencias estadísticas significativas.

The aim of the present study was the in vitro evaluation of the response, within 96 hours, of gingival fibroblast cultures with respect to different endodontic sealers. Results obtained at time intervals of 0, 1, 2, 3, 6, 24, 48, 72 and 96 hours were used to determine sealers' cytotoxicity. Gingival fibroblasts cultures without root canal sealer and with Sealapex were used as negative and positive controls respectively. Results were compared with negative controls and statistically analyzed with t Dunnett test (p ≤ 0.05). Assessed sealing cements were: ProRoot MTA, grey and white, CPM, MTA Angelus, Sealapex and GuttaFlow. Results showed that even though ProRoot MTA (grey and white) MTA Angelus, CPM and GuttaFlow exhibited lower cytotoxic potential than Sealapex, no statistical significant differences were established.

Aplicação da Movimentação Passiva Contínua (CPM) na reabilitação do cotovelo: uma revisão da literatura / Aplicación de Movimiento Pasivo Continuo (CPM - MPC) en la rehabilitación del codo: una revisión de la literatura / Application of Continuous Passive Motion (CPM) in elbow rehabilitation: a literature survey

A Movimentação Passiva Contínua (CPM) é utilizada na reabilitação após trauma ou cirurgia articular, e sua aplicação pode gerar resultados positivos na reabilitação dos membros. Este estudo teve como objetivo analisar e discutir a utilização de equipamentos de CPM na reabilitação do cotovelo a partir de uma revisão bibliográfica de estudos publicados nos últimos 10 anos. Esta pesquisa bibliográfica foi realizada em banco de dados informatizado da Biblioteca Virtual em Saúde, EBSCO HOST, PeDRO, Biblioteca Cochrane e Science Direct. Para localizar os estudos, foram utilizadas palavras-chave: movimento passivo contínuo, cotovelo e CPM cotovelo, em Português e Inglês. Foram selecionados artigos completos em português, inglês e espanhol. A estratégia de pesquisa estava focalizada em estudos do tratamento de patologias do cotovelo utilizando a CPM como método isolado ou associado a outras técnicas fisioterapêuticas. A amostra foi composta de 16 publicações de periódicos. Em 11 dos artigos, a aplicação da CPM associada ou não a outros métodos fisioterapêuticos gerou resultados benéficos; um não apresentou diferença quando comparada a utilização ou não da CPM; dois demonstraram resultados positivos, ressaltando cuidados específicos; e dois afirmam ser necessário mais estudos para comprovação de resultados. Portanto, foi possível evidenciar que pesquisas estão explorando a utilização da CPM na reabilitação do cotovelo, porém os parâmetros utilizados e os modos de aplicação do equipamento não estão bem especificados. Além disso, foi possível perceber que a CPM está sendo utilizada como adjuvante aos métodos de reabilitação fisioterápica e prevalecemos resultados positivos.

Continuous Passive Motion (CPM) is used in post-trauma or articulations surgery rehabilitation to articulate, and its application may produce positive results in members` rehabilitation. This study aimed to analyze and to discuss the use of CPM equipment in elbow rehabilitation through a bibliographical survey of studies published in the last 10 years. This bibliographical survey was done in a computerized databank of Virtual Library in Health, EBSCO HOST, PeDRO, Cochrane Library and Science Direct. For locating studies, we used the keywords continuous passive movement, elbow and elbow MPC/CPM in English, Portuguese and Spanish. Complete articles in Portuguese, English and Spanish were selected. The research strategy focused on studies of the treatment of elbow pathologies using CPM as an isolated method and associated to other physiotherapeutic techniques. The sample was composed by 16 newspaper articles. In 11 articles, CPM application associated or not to other physiotherapeutic methods, has produced beneficial results; 1 did not present differences in the comparison between the use of (CPM) and the use of other techniques; 2 presented positive results, emphasizing specific cares, and 2 called for more studies for result verification. Therefore, it was possible to shoe that researchs are now exploring the use of CPM in elbow rehabilitation, but parameters used and application methods are not well explained. In addition, it was possible to perceive that today CPM is used as an adjuvant method of physiotherapeutic rehabilitation, with the prevalence of positive results.

El Movimiento Pasivo Continuo (MPC) es utilizado en la rehabilitación post-trauma o cirugía articular y su aplicación puede generar resultados positivos en la rehabilitación de los miembros. Este estudio tuvo como objetivo analizar y discutir la utilización de equipamientos de MPC en la rehabilitación del codo a través de una revisión bibliográfica de estudios publicados en los últimos 10 años. Esta investigación bibliográfica fue realizada en un banco de datos informatizado de la Biblioteca Virtual en Salud, EBSCO HOST, PeDRO, Biblioteca Cochrane y Science Direct. Para localizar los estudios, fueron utilizadas las palabras-llave movimiento pasivo continuo, codo y CPM codo en Portugués y Inglés. Se seleccionaran artículos completos en portugués, inglés y español. La estrategia de investigación focalizó estudios del tratamiento de patologías del codo que utilizaban el CPM como método aislado o asociado a otras técnicas fisioterapéuticas. La muestra se compuso de 16 artículos de periódicos. En 11 de los artículos, la aplicación del CPM, asociada o no a otros métodos fisioterapéuticos, ha producido resultados benéficos; 1 no presentó diferencia en la comparación entre la utilización o no del CPM; 2 han demostrado resultados positivos, resaltando cuidados específicos, y 2 afirman se necesitar de más estudios para la comprobación de resultados. Por consiguiente, fue posible evidenciar que investigaciones exploran en la actualidad la utilización de la CPM en la rehabilitación del codo, mas los parámetros utilizados y los modos de aplicación del equipamiento non están bien especificados. Además, fue posible percibir que la CPM es hoy utilizado como adyuvante de los métodos de rehabilitación fisioterápica, prevaleciendo los resultados positivos.

Central Pontine Myelinolysis Presenting With Cerebellar Ataxia

Central pontine myelinolysis (CPM) is a neurologic disorder that is usually related to rapid correction of hyponatremia and chronic alcoholism. CPM involves concentrated, symmetric, noninflammatory demyelination within the central pons; this pathology also occurs in extrapontine regions. Frequently observed clinical manifestations are sudden weakness, dysphagia, dysarthria, loss of consciousness, and locked-in syndrome. We describe herein a case of CPM predominated by cerebellar signs without typical symptoms, but with involvement of the cerebellum or cerebellar peduncle.

Effect of Continuous Passive Motion on Hand Spasm and Hand Function of Hemiplegic Patients / 中国康复理论与实践

@#Objective To observe the effects of hand function training with continuous passive motion (CPM) on hand spasm and function of the hemiplegic patients.Methods 60 hemiplegic patients after stroke or brain trauma and with hand spasm were randomly divided into the treatment group and control group with 30 cases in each group. The cases in the treatment group were treated mainly with the method of CPM together with the routine rehabilitation procedures, while the those in the control group were only treated with the routine rehabilitation procedures. The changes of hand spasm and function of two groups were observed.Results After four weeks' treatment, the efficacy of the treatment group was obviously better than that of the control group ( P<0.05).Conclusion The rehabilitation training is an effective method for treatment of hemiplegia, and CPM is an important auxiliary method in the treatment. These two Methods combined together can shorten the course of treatment, and strengthen cure efficacy.

Sealing ability of grar MTA AngelusTM, CPM TM and MBPc used as apical plugs

This study evaluated the sealing ability of apical plugs fabricated with gray MTA AngelusTM sealer, CPM TM sealer and MBPc sealer. The root canals of 98 extracted single-rooted human teeth were instrumented with #5 to #1 Gates Glidden drills according to the crown-down technique until the #1 drill could pass through the apical foramen. The specimens were then prepared with K-files, starting with an ISO 50 until an ISO 90 could be visualized 1 mm beyond the apex. After root canal preparation, the external surface of each root was rendered impermeable and roots were assigned to 3 experimental groups (n = 30), which received a 5-mm thick apical plug of gray MTA AngelusTM, CPM TM and MBPc, and two control groups (n=4). The remaining portion of the canal in the experimental groups was filled by the lateral condensation technique. The teeth of each group, properly identified, were fixed on utility wax by their crowns and were placed in plastic flasks, leaving the apex free and facing upward. The flasks were filled with 0.2 percent Rhodamine B solution, pH 7.0, so as to completely cover the root apex of all teeth. The sealing ability was analyzed by measuring 0.2 percent Rhodamine B leakage after all groups had been maintained in this solution for 48 hours. Data were analyzed statistically by Kruskal-Wallis test and Dunn test with a=5 percent. The results showed that, among the tested materials used for fabrication of apical plugs, MBPc sealer had the least amount of leakage with statistically significant difference (p<0.05).

Effects of Continuous Passive Motion and Rehabilitation on Flexion of Shoulder after Intensive Burn / 中国康复理论与实践

@#Objective To investigate the effect of continuous passive motion(CPM) and rehabilitation on flexion of the shoulder after intensive burn.Methods 36 patients with intensive burn on upper limb(including the skin around axilla fossa) were divided randomly into CPM group(n=19) and control group(n=17).The CPM group received both routine rehabilitation and continuous passive motion treatment,and the control group only underwent routine rehabilitation treatment.Their ranges of active or passive motion were assessed.Results There was a significant improvement both in the CPM group and the control group after treatment(P<0.01),but the CPM group improved more(P<0.05).Conclusion CPM can improve the efficacy of the routine rehabilitation on flexion of the shoulder after intensive burn.

Effect of Early Rehabilitation Training Combined with Continuous Passive Motion on Knee Joint Function after Total Knee Arthroplasty / 中国康复理论与实践

@#Objective To observe the effect of early rehabilitation training combined with continuous passive motion (CPM) on knee joint function after total knee arthroplasty (TKA).Methods23 patients (28 knees) post TKA were randomly divided into the treatment group (15 knees) and control group (13 knees). The patients of the treatment group were treated with early rehabilitation training combined with CPM, and those of the control group were treated with CPM only.ResultsThe scores of knee grade and function grade of the treatment group were not different from those of the control group before treatment ( P>0.05), but two weeks later, there was a significnat difference between two groups ( P<0.01).ConclusionThe early rehabilitation training combined with CPM can improve recovery of function of knee joint after TKA.

Central Pontine and Extrapontine Myelinolysis without Hyponatremia after Alcohol Withdrawal: One Case Report

Central pontine myelinolysis (CPM) is a demyelinating disorder that was first described by Adams et al. in 1959 in patients with a history of alcoholism and malnutrition. It is characterized by delirium, quadriparesis, pseudobulbar palsy, and dysarthria. A subgroup of patients at risk for CPM are chronic alcoholics, malnutrition, diabetes, liver transplantation, hepatic disease, advanced age. Although the cause and pathogenesis remains unclear, but many studies have implicated that the rapid correction of hyponatremia is the major factor associated with CPM. But CPM without hyponatremia has been rarely reported. Diagnosis is confirmed by MR image. Here we present one case of CPM without electrolyte disturbance after alcohol withdrawal in a chronic alcoholic with literature reviews.

Effects of Continuous Passive Motion on Blood Oxygen Saturation in Local Wound Tissue after Anterior Cruciate Ligament Reconstruction in Rabbits / 中国微创外科杂志

Objective To study the effects of continuous passive motion(CPM)on tissue blood oxygen saturation(StO2)in the edge of wound after anterior cruciate ligament(ACL)reconstruction in rabbits.Methods Twenty male New Zealand rabbits,aged 8 months,received an ACL reconstruction by using double semitendinous tendon autograft in the right hind leg.The rabbits were randomly divided into 2 groups postoperatively,namely Cage activity group(n=10)and CPM group(n=10),treated with cage activity and activity by rabbit knee joint continuous passive motion apparatus respectively.On the following day after operation,a near-infrared optical device and ODISseyTM Tissue Oximeter were applied to measure the changes of tissue oxygen saturation(StO2)in the edge of the wound in each cycle(with flexion of 30?-110?)and various CPM speeds(2.35?/s,3.2?/s,and 8?/s),and the optimal CPM range and speed was thus selected for analyzing the changes of StO2 in local tissues of wounds with various angles of CPM in knee joint before the operation and on the 2nd,4th,6th,8th,10th,and 14th postoperative days.Results There was a significant difference with regard to StO2 between CPM group and Cage activity group(P0.05),however,a significant difference was observed among different time points(before the operation,and 2,4,6,8,10,14 days after the operation)(P

Clinical effect of dynamic hip screw combined with CPM on intertrochanteric fractures in old patients / 中国康复理论与实践

@#ObjectiveTo investigate the clinical effect of dynamic hip screw (DHS) combined with continuous passive motion (CPM) on intertrochanteric fractures in old patients.MethodsThirty-six old patients with intertrochanteric fractures were treated with DHS internal fixation and began to exercise isometric contraction of quadriceps femoris and to move the big joints of affected limb with CPM machine on the 3rd day after operation.ResultsAll the patients were averagely followed-up for 14 months. According to the effective standard, 26 cases were excellent, 9 cases good and 1 case poor with a 97.2 percentage of fineness. All fractures healed well with no loosening and dislocation of internal fixation. Only one case with type of Evans Ⅲ remained less hip inversion.ConclusionDHS is a good method to treat intertrochanteric fractures of old patients under good preoperative disposal.

Analysis of 4 cases with central pontine myelinolysis and extral pontine myelinolysis / 中国康复理论与实践

@#ObjectiveTo explore the pathogeny, diagnosis and rehabilitation of central pontine myelinolysis.MethodsClinical data of four patients with central potine myelinolysis were studied retrospectively.ResultsAll of them had pseudobulbar palsy and dystonia; three had coma; two had history of hyposodemia ameliorated rapidly, one had history of hypersodemia ameliorated rapidly. All of them had focuses in pons; three had focuses beyond pons. All patients had good prognoses.ConclusionHistory of hyposodemia ameliorated rapidly is a usual pathogeny of central potine myelinolysis, integrative measures of rehabilitation can improve prognosis and quality of daily life.

Effect of continuous passive motion on postoperative functional rehabilitation in lower limb / 中国康复理论与实践

@#ObjectiveTo observe the effect of continuous passive motion (CPM) on postoperative functional rehabilitation in lower limb.Methods267 patients operated in lower limb were separated to CPM group (162 cases) and control group (105 cases). Patients of the CPM group used CPM device at early period post operation, and cases of the control group received instruction to exercise by themselves. The efficacy of two methods was evaluated.ResultsThe knee activity of affected extremity of CPM group at 10 day and 1 month was better than that of control group, as well as the rate of swelling extinction of affected extremity (P<0.05～0.01).ConclusionIt is propitious to functional rehabilitation of patients operated in lower limb that using CPM early post operation.

Effect of continuous passive motion on postoperative functional rehabilitation in lower limb / 中国康复理论与实践

@#ObjectiveTo observe the effect of continuous passive motion (CPM) on postoperative functional rehabilitation in lower limb.Methods267 patients operated in lower limb were separated to CPM group (162 cases) and control group (105 cases). Patients of the CPM group used CPM device at early period post operation, and cases of the control group received instruction to exercise by themselves. The efficacy of two methods was evaluated.ResultsThe knee activity of affected extremity of CPM group at 10 day and 1 month was better than that of control group, as well as the rate of swelling extinction of affected extremity (P<0.05～0.01).ConclusionIt is propitious to functional rehabilitation of patients operated in lower limb that using CPM early post operation.

The influence of continuous passive motion on joint function of the k nee after arthroscopy / 中华物理医学与康复杂志

Objective To study the effect of con tinuous passive motion (CPM) on joint function after arthroscopy in the knee jo int. Methods Arthroscopy examinations and operations were performed in 53 patients. They were divided into study and control groups based on the use or not of CPM immediately in the postoperative period. The cont rol group consisted of 25 patients treated without postoperative CPM and the stu dy group consisted of 28 patients treated with CPM postoperatively. Range of mot ion (ROM) and the comprehensive function score of the knee joint were evaluated preoperatively, at discharge and at three months after operation. Results There were statistically significant differences in the f unction score of the knee joint between the two groups at discharge. The mean f lexion and extension in the study group were 90.64??16.57? and -0.71??3.78 ?, respectively, compared to 69.40??15.17? and -4.32??4.71? in the contro l group. The mean of the comprehensive function score of the knee joint in the c ontrol group were 11.24.compared to 8.89 in the study group. Seventy-five perce nt (21 cases) of the patients in the CPM group and 24% (6 cases)of patients in t he control group had achieved 90? of flexion at the time of hospital discharge. Conclusion CPM had enhanced the therapeutic effects of arthroscopy in the knee joint and shortened the length of stay of the patie nts in the hospital. Further investigation is needed for evaluating the long-te rm effect of CPM.