RESUMO
Congenital self-healing reticulohistiocytosis is a variant of cutaneous Langerhans cell histiocytosis seen in newborns. It is characterized by generalized brownish to erythematous papules or nodules that resolve spontaneously within several weeks to months, without involvement of other organs. Erythematous erosive patches or vesicles are rare clinical features of congenital self-healing reticulohistiocytosis; only 11 cases have been reported in the literature. A newborn female presented with erythematous erosive patches and vesicles on the whole body without systemic symptoms. Histopathologically, multiple lymphocytes and histiocytic cells with kidney shaped nuclei were observed in the dermis. Immunohistochemical stain showed positive reactions for CD1a and S100 in histiocytic cells in the dermis. All lesions involuted spontaneously within a month without treatment. Here we report a rare case of congenital self-healing reticulohistiocytosis presenting as erythematous erosive patches and vesicles, with a literature review.