Pindborg tumor associated with a supernumerary tooth: a case report

The calcifying epithelial odontogenic tumor is a rare benign neoplasm that accounts for approximately 1% of all odontogenic tumors. Most of the cases occur in the posterior mandible, and a few involve the maxilla. Despite their relatively indolent biological behavior, tumors in the maxilla tend to grow fast. We report the case of a 33-year-old female patient exhibiting swelling in the right maxilla. An isodense area associated with an impacted supernumerary tooth was found on imaging examination. The histopathologic diagnosis was a calcifying epithelial odontogenic tumor. The treatment of choice was surgical removal of the lesion and associated dental elements. The patient has been followed up for 11 months and shows no signs of recurrence. Besides describing this case, we reviewed the literature on the association of calcifying epithelial odontogenic tumors with supernumerary teeth and found two case reports addressing this subject.

A case report of maxillary calcifying epithelial odontogenic tumor in a teenage girl

Objective@#To report the case of a rare benign odontogenic tumor in an adolescent girl which was successfully managed by complete excision and curettage of underlying bone. @*Methods@#Design: Case Report. Setting: Tertiary National University Hospital. Patient: One. @*Result@#A 15-year-old girl with a 3-year history of a large Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor) atypically occurring in the posterior maxillary alveolar ridge and compressing the maxillary antrum underwent tumor excision via gingivobuccal approach and curettage of the emaining mucosa in the cavity in consideration of her patient’s aesthetic concerns. No recurrence has been observed two years post-op and she remains asymptomatic on regular follow-up. @*Conclusion@#A calcifying epithelial odontogenic tumor can be managed conservatively with close follow-up to monitor recurrence.

Tumor Odontogénico Epitelial Calcificante maxilar superior: reporte de un caso / Calcifying Epithelial Odontogenic Tumor in upper maxillary: a case report

RESUMEN: El Tumor Odontogénico Epitelial Calcificante (TOEC), también denominado Tumor de Pindborg, se define como una neoplasia benigna, caracterizada por la proliferación epitelial; presenta secreción de una proteína tipo amiloide con tendencia a la calcificación. Representa menos del 1% de los tumores odontogénicos. Reportamos un caso en paciente de 75 años con un TOEC en la región maxilar izquierda en relación a una pieza dentaria incluida. El caso no mostró sintomatología específica, sólo una expansión de corticales vestibular y palatina. El diagnóstico se confirmó histológicamente mediante biopsia incisional y extirpación quirúrgica de la lesión, mostrando una histomorfología clásica para este tipo de lesiones. Reportamos este caso para resaltar la edad de presentación inusual, especialmente su localización e ilustrar su abordaje terapéutico y seguimiento.

ABSTRACT: The Calcifying Epithelial Odontogenic Tumor (CEOT), also called Pindborg Tumor, is defined as a benign neoplasm, characterized by epithelial proliferation; secretion of an amyloid-like protein is present with a tendency to calcification. It represents less than 1% of odontogenic tumors. We report a case of a 75-year-old patient with a TOEC in the left maxillary region in relation to an included tooth. The case did not show specific symptomatology, only an expansion of vestibular and palatal corticals. The diagnosis was confirmed histologically by incisional biopsy and surgical removal of the lesion, showing a classic histomorphology for this type of lesions. We report this case to highlight the unusual age of presentation, especially its location and to illustrate its therapeutic approach and follow-up.

Tumor infrecuente de los maxilares, tumor de Pindborg: presentación de un caso clínico / Infrequent tumor of the jaws, Pindborg tumor: report of a clinical case

El tumor odontogénico epitelial calcificante o tumor de Pindborg es una neoplasia odontogénica benigna y poco frecuente que afecta predominantemente la mandíbula. El objetivo de este trabajo fue reportar y discutir un caso clínico de una mujer de 65 años de edad que presentaba un tumor de Pindborg en la zona de sínfisis mentoniana. El diagnóstico presuntivo se realizó según los hallazgos clínicos y radiográficos. Se efectuó una biopsia incisional que confirmó el diagnóstico. El tratamiento se basó en la resección completa de la masa tumoral con legrado óseo quirúrgico periférico. Para la prevención de la fractura patológica, se colocó una placa de reconstrucción y relleno óseo en la lodge posquirúrgica. A pesar del porcentaje de recidiva en casos reportados en la literatura, el tratamiento fue conservador y el control a distancia después de 6 años fue favorable (AU)

The calcifying epithelial odontogenic tumor (CEOT) or Pindborg tumor, is a rare benign but locally aggressive odontogenic neoplasm that affects the jaw. We report and discuss a case of a 65-year-old woman who presented a Pindborg tumor located in the mandibular symphysis region. The presumptive diagnosis was carried out by means of clinical and radiologic findings. The diagnosis was confirmed by the histological examination. Then, a resection of the entire mass was done, with osseous curettage. Reconstruction was achieved using a reconstruction plate system and bone void filler. Because of the risk of recurrence, the patient was followed closely. At the last follow-up examination 6 years after treatment the panoramic radiograph demonstrated that the cavity was almost completely ossified without any sign of CEOT recurrence (AU)

Clinical pathological study of 30 cases of cutaneous calcifying epithelioma / 重庆医学

Objective To investigate the clinical and pathological diagnosis of cutaneous calcifying epithelioma.Methods Thirty cases of calcified epithelioma were diagnosed and treated by our hospital.The clinical features and pathological features were retrospectively reviewed.Results The main pathological features of the tumor were that the main tumor (basophilic cells) basal cells and shadow cells were mixed composition,combined with ossification and calcification and with no recurrence after surgical resection.Conclusion The clinical manifestations of calcifying epithelium are lack of characteristics and diverse pathological features.It is necessary to make the correct pathological diagnosis with the time,location and imaging of tumor growth.

Epithelial odontogenic tumors: analysis of 156 cases in a Brazilian population / Tumores odontogénicos epiteliales: análisis de 156 casos en una población brasileña

The objective of this study was to determine the distribution of epithelial odontogenic tumors diagnosed histologically in a period of 41 years in a Brazilian population according to age, gender, site affected and compare these data with previously reported studies from other countries. Data of epithelial odontogenic tumors diagnosed were collected from the files of the Oral Pathology Laboratory of Federal University of Rio Grande do Norte, Natal, RN, Brazil, and entered in a standardized form for later comparisons. Clini-cal features obtained from the patient records and microscope slides were reviewed according to the 1992 World Health Organization classification. A total 156 epithelial odontogenic tumor were reported. Of these, all of them were benign. Ameloblastoma was the most frequent type (85.9 %), followed by adenomatoid odontogenic tumor (10.9 %) and calcifying epithelial odontogenic tumor (3.2 %). The mean age of the patients was 38 years, with a wide range (11­80 years). The posterior region of mandible was the anatomic site most frequently affected by this disease, and no significant differences were found between sexes in the diagnosis of odontogenic tumors. A marked geographic variation in the relative incidences of various epithelial odontogenic tumors was found. It was particularly notable in ameloblastomas and adenomatoid odontogenic tumors, with the incidences observed in the present study being similar, sometimes different to earlier studies in others parts of the world.

El objetivo fue determinar la distribución de los tumores odontogénicos epiteliales diagnosticados histológicamente en un período de 41 años en una población brasileña según edad, sexo y la zona afectada y comparar estos datos con estudios anteriores de otros países. Los datos de los tumores odontogénicos epiteliales diagnosticados fueron obtenidos de los archivos del Laboratorio de Patología Oral de la Universidad Federal de Rio Grande do Norte, Natal, RN, Brasil, e introducidos en un formulario estandarizado para comparaciones futuras. Las características clínicas obtenidas a partir de los registros de los pacientes y los portaobjetos de microscopio fueron revisados de acuerdo a la clasificación de la Organización Mundial de la Salud 1992. Se informó de un total de 156 tumores epiteliales odontogénicas. De estos, todos eran benignos. Ameloblastoma fue el tipo más frecuente (85,9 %), seguido por el tumor odontogénico adenomatoide (10,9 %) y el tumor odontogénico epitelial calcificante (3,2 %). La edad media de los pacientes fue de 38 años, con un rango amplio (11­80 años). La región posterior de la mandíbula era el sitio anatómico más afectado por esta enfermedad, y no se encontraron diferencias significativas entre sexos en el diagnóstico de los tumores odontogénicos. Se encontró una marcada variación geográfica en las incidencias relativas de diversos tumores odontogénicos epiteliales. Fue particularmente notable en ameloblastomas y tumores odontogénicos adenomatoide, con las incidencias observadas en este estudio siendo a veces similares, y a veces diferentes de los estudios anteriores en otras partes del mundo.

Calcifying Epithelial Odontogenic Tumor (Ceot).

Calcifying epithelial odontogenic tumor is a rare benign epithelial odontogenic lesion that comprises from 0.2% to 1.1 of all odontogenic tumors. In the past a number of different names have been given to this lesion, such as calcifying ameloblastoma, cystic complex odontoma, uncommon ameloblastoma with calcifications and others. There is a need to study and explore various aspects of this tumour, this article gives a broad idea of the various aspects of this tumor and which aspect of this tumour needs more investigation

Calcifying epithelial odontogenic tumor associated with the left mandibular first premolar: a case report and literature review

Calcifying epithelial odontogenic tumor (CEOT) is a rarely reported benign tumor, accounting for 0.4-3% of all odontogenic tumors. Approximately 150 cases have been reported in the literature between 1958 and 2003. The age range of CEOT varies from 8 to 92 years with mean of 36.9 years, and the occurrence of the lesion in both genders is almost equal. It has 2 clinico-topographic variants: the intraosseous (94%) and the extraosseous (6%) type. The intraosseous type has a predilection for mandible (maxilla : mandible ratio of 1 : 2). The intraosseous CEOT commonly associated with non-erupted teeth accounts for more than half (52%) of the cases and usually appears as painless swelling that causes bony expansion. The location of diffused round-shaped calcifying material is inside the connective tissue stroma and epithelial islands. The tumors tend to be located toward the tooth crown, which usually has a unilocular radiolucent region containing variant radiopaque materials radiologically. In this paper, we report a case of CEOT occurring in the left mandibular first premolar of a 23-year-old female and present a brief review of the literature.

Tumor de Pindborg relacionado con trauma facial / Pindborg's tumor in relationship with facial traumata

El tumor de Pindborg es una neoplasia benigna, rara, con carácter invasivo local y tendencia a la recidiva, que representa entre el 0,17 y el 1,8 por ciento de todos los tumores odontogénicos, del cual tan solo se han publicado unos 200 casos, con una media de 4 casos nuevos por año en el mundo. Se presentó el caso de un hombre de 39 años de edad que acudió a la consulta de cirugía maxilofacial remitido de neurocirugía postraumatismo craneofacial, por presentar un aumento de volumen en el ángulo mandibular derecho. Se tuvo como objetivo publicar la existencia de esta infrecuente neoplasia por lo interesantes que resultan estos tumores por su evolución, dificultad en el diagnóstico, variantes de tratamiento y tendencia a la recidiva. Después de realizar exámenes de laboratorio, radiografías, tomografía axial computarizada y biopsia de fragmento óseo, se obtuvo extensión y diagnóstico de tumor de Pindborg en hemimandíbula derecha. Se realizó la técnica quirúrgica de hemimandibulectomía derecha y reconstrucción con injerto óseo de cresta ilíaca. La evolución del paciente fue satisfactoria(AU)

The Pindborg's tumor is a benign and uncommon neoplasm with a local invasive character and a trend to relapse accounting for the 0.17 and the 1.8 percent of all odontogenic tumors with only 200 cases published in the literature and a mean of four cases per year at world scale. This is the case of a man aged 39 came our consultation of Maxillofacial Surgery referred from Neurosurgery Service after a craniofacial trauma and an increase of volume in right mandibular angle with the aim to publish the existence of this uncommon neoplasm due to the interesting of this type of tumor by its evolution, difficulty for diagnosis, variants of treatment and trend to relapse. After carry out laboratory examinations, X-rays, axial tomography computerize and biopsy of bone fragment, it was possible the extension and diagnosis of Pindbog's tumor in right hemi-mandible. The right hemimandibulectomy is performed as surgical technique and the reconstruction using bone graft of iliac crest. Evolution of patient is satisfactory(AU)

Calcifying epithelial odontogenic tumor (CEOT) in palate: report of a case

A calcifying epithelial odontogenic tumor (CEOT) was first described as a separate entity in 1955 by Pindborg, and has since been referred to as Pindborg tumor. CEOT is characterized by the presence of squamous-cell proliferation, calcification and amyloid deposits, and accounts for only 1% of all odontogenic tumors. CEOT is a benign, though occasional locally invasive, slow-growing neoplasm. It is located either intraosseously or extraosseously, and is usually associated with an unerupted permanent tooth. A 24 year-old female visited our clinic, presenting with a palatal swelling and intra-oral ulcer. After an incisional biopsy, the lesion was confirmed to be odontogenic tumor. A tumor resection and reconstruction surgery with tongue flap were performed.

Pindborg Tumor in an Adolescent- An Atypical Presentation.

Calcifying epithelial odontogenic tumor (Pindborg tumor), is a rare benign odontogenic neoplasm representing about 0.4-3% of all odontogenic tumors. This tumor more frequently affects adults in an age range of 20- 60 years, with a peak incidence in the 5th decade of life. Calcifying epithelial odontogenic tumour has a much lower recurrence rate than ameloblastoma and malignant transformation with metastasis is rare.

Pindborg Tumor on Hard Palate / 대한이비인후과학회지

Pindborg tumor occurs rarely, with a frequency ranging from 0.17% to 1.8% of all odontogenic tumor. It typically presents as a painless asymptomatic expansile mass, but it can result in mechanical effects. The treatment of Pindborg tumor in the past has varied, ranging from enucleation or curettage, to hemimandiblectomy or hemimaxillectomy. We experienced a case of Pindborg tumor treated by marsupialization with sufficient results. But since recurrence has been reported from 10% to 14%, we plan on close observation over at least 5 years.