Vitamin D and tuberculosis / Vitamina D e tuberculose

BACKGROUND AND OBJECTIVES: The vitamin can be obtained from certain foods or through the exposition to solar light. It works together the parathyroid hormone to keep the sanguineous calcium levels, but it has an interesting participation inimmunologic mechanisms of regulation, mainly of the infectious illnesses, being present in the history of the tuberculosis for a long time. The aim of this study is to revise what has been published, on the role of vitamin D in the tuberculosis physiopathology.CONTENTS: This review deals with immunological mechanisms in tuberculosis infection, the involvement of vitamin D in this mechanisms and what is its applicability in clinical practice for the treatment of tuberculosis.CONCLUSION: Vitamin D can be beneficial as adjuvant therapy in the treatment of tuberculosis. It would be appealing, in a country with our features, that a greater interest in the study of this topic occurred.

JUSTIFICATIVA E OBJETIVOS: A vitamina pode ser obtida dos alimentos ou através da exposição à luz solar. Trabalha junto com o hormônio paratireoideano para manter os níveis de cálcio sanguíneo, mas tem uma interessante participação em mecanismos de regulação imunológicos, principalmente das doenças infecciosas,estando presente na história da tuberculose há muito tempo. O objetivo deste estudo foi revisar o do que já foi publicado,sobre o papel da vitamina D na fisiopatologia da tuberculose.CONTEÚDO: Esta revisão trata sobre mecanismos imunológicos na infecção por tuberculose, o envolvimento da vitamina D nesses mecanismos e qual a sua aplicabilidade na prática médica para o tratamento da tuberculose.CONCLUSÃO: A vitamina D pode ser benéfica como terapia adjuvante no tratamento da tuberculose. Seria atraente, em um país com características climáticas e econômicas como o Brasil,que ocorresse um interesse maior no estudo desse tema.

The relationship between vitamin D receptor gene TaqⅠ polymorphism and diabetic retinopathy / 中华眼底病杂志

Objective To investigate the polymorphism of the vitamin D receptor gene (VDR)TaqⅠin relation to diabetic retinopathy. Method Fragment length discrepant allele specific PCR(FLDAS-PCR) were used to determine VDR genetypes in 158 patients with diabetic retinopathy and in 198 normal subjects. Results The frequency distribution of VDR genotypes in diabetic retinopathy patients was 106 (67.1%) in TT, 33(20.9%) in Tt, 19(12.0%) in tt; and in normal persons was 165 (83.3%) in TT, 23(11.6%) in Tt, 10 (5.1%) in tt. There was a significant difference between diabetic retinopathy patients and normal persons in distribution of VDR gene TaqⅠgenotypes(P