Electron Microscopic Studies on Invasion of Malignant Cells to Collagen / 昆明医科大学学报

The degradation of collagen in the extracellular matrix induced by malignant cells is a very impotant link in the cancerometastasis chain.The invasive and destructive effect of vari- ous types of malignant cells cultured in vitro on the three dimensional gel of the native collagen fibrils was observed by electron microscopy.The cytobiological properties of malig- nant cells were discussed and compared with the normal ones.