RESUMO
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
Assuntos
Humanos , Células A549 , Alcaloides , Química , Toxicidade , Antineoplásicos , Química , Toxicidade , Carbazóis , Química , Toxicidade , Linhagem Celular Tumoral , Sobrevivência Celular , Clausena , Química , Células HeLa , Estrutura Molecular , Extratos Vegetais , Química , Toxicidade , Folhas de Planta , Química , Caules de Planta , Química , Plantas Medicinais , QuímicaRESUMO
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
Assuntos
Humanos , Células A549 , Alcaloides , Química , Toxicidade , Antineoplásicos , Química , Toxicidade , Carbazóis , Química , Toxicidade , Linhagem Celular Tumoral , Sobrevivência Celular , Clausena , Química , Células HeLa , Estrutura Molecular , Extratos Vegetais , Química , Toxicidade , Folhas de Planta , Química , Caules de Planta , Química , Plantas Medicinais , QuímicaRESUMO
The genus Clausena Burm.f. (family Rutaceae) concerns 25 species all over the world, and 13 species are native to China especially in the southwest and south of China, Yunnan Province has 11 species. The chemical composition from Clausena Burm.f. included carbazole alkaloids, coumarins, sesquiterpenes, benzene derivatives, tetranortriterpenoids, flavonoids and so on. The carbazole alkaloids have attracted much attention in recent years. The recent research progress on carbazole alkaloids from Clausena Burm.f. was reviewed in this paper about the structures, isolation, structure elucidation, and biological activities.
RESUMO
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.