RESUMO
Background: A total 4-11% of women in India are affected by PCOS. Studies show that incidence and prevalence is increasing. It is a constellation of metabolic and endocrine abnormalities with significant cost to quality and quantity of life. Aim of this study was to find out the association of metabolic syndrome with PCOS. Objectives of this study were identified subjects suffering from PCOS and measure strength of association of metabolic syndrome.Methods: Case-control study conducted in the department of Obstetrics and Gynaecology Agartala Government Medical College, Agartala, Tripura from January 2017 to June 2018. Fifty cases were diagnosed by Rotterdam criteria and 50 cases age matched controls were recruited. Hundred subjects underwent evaluation for metabolic syndrome according to ESHRE/ASRM criteria. Statistical analysis was done using SPSS 17.0.Results: Mean age was 19.4±3.5 years. Oligomenorrhea found in 42 out of 50 cases. Hirsutism found in 54% of cases. There is a statistically significant difference in weight, BMI and waist circumference among PCOS cases and controls. Hypertriglyceridemia was found to be significantly higher among PCOS cases. Fasting glucose and 2-hour OGTT were found to be statistically significantly different. No association was found between metabolic syndrome and clinical hyperandrogenism, but metabolic syndrome was significantly associated with higher BMI. BMI, Hip circumference and oral glucose tolerance test were independent predictors of polycystic ovarian syndrome. Metabolic syndrome was present in 34% of cases. The odds ratio of having metabolic syndrome in a case of PCOS is 5.92.Conclusions: Association between PCOS and metabolic syndrome is statistically significant. The two entities are intrinsically linked to each other and early identification of one may lead to the diagnosis and management of the other.
RESUMO
Background: Polycystic ovarian syndrome (PCOS) is the multisystemic disorder and most common reproductive endocrinopathy of women during their childbearing years, expressed in wide varieties of clinical signs and symptoms. It is characterized by a varied and often complex array of metabolic and endocrine abnormalities, including hyperinsulinaemia, hyperglycaemia, glucose intolerance and obesity which put women with PCOS at a higher risk for diabetes, hypertension, dyslipidemia, and cardiovascular disease. Objectives: To estimate Fasting blood glucose and lipid profile in women with PCOS and normal females. Materials and Methods: After Ethical Committee Approval, blood samples were collected from 50 diagnosed PCOS cases and 50 healthy controls (premenopausal women); aged 18 to 40 years. Fasting plasma glucose and lipid profile were investigated in both PCOS patients and controls. The correlation between these biochemical parameters were then studied in the PCOS group. Data analysis done using studentʽ t’ test. Results: There was a significant increase in fasting plasma glucose levels in PCOS patients as compared to controls. PCOS women had higher BMI with increased total cholesterol, TGL, LDL-C, VLDL-C and lower HDL-C (P < 0.05) as compared to the controls which was statistically significant. The levels of glucose showed significant positive correlation with total cholesterol(P<0.01), triglycerides(P<0.05), LDL-C (P<0.01) whereas non-significant negative correlation with HDL-C. Conclusion: The findings of this study confirms the association between Glucose, BMI and dyslipidaemia in PCOS and may help to identify women with PCOS at risk of cardio metabolic syndrome thereby confirming the association between PCOS and cardiovascular risk factors.