RESUMO
Objective:To investigate the effect of perineural invasion (PNI) on patients with early squamous cell carcinoma of the tongue (ESCCT) and the controversial issues related to PNI's effect on loco-regional recurrence, cervical lymph node metastases, and prognosis. Methods:Data of 156 patients with ESCCT were analyzed. Two subgroups comprising 40 patients each were investigated. One was PNI-positive subgroup, and the other subgroup was consisted of patients with PNI-negative carcinomas. These patients had similar histopathological characteristics and were randomly selected from the total number of cases. The relationship among the prevalence of PNI, loco-regional recurrence, cervical lymph node metastases, and prognosis was analyzed. Results:PNI was significantly correlated with high cervical lymph node metastases and poor 5-year survival rates (P=0.045 and P=0.034, respectively) but not with local recurrence (P=0.531). Elective neck dissection was considerably associated with a low risk of regional recurrence among the PNI-positive ESCCT patients (P=0.001). Conclusion:PNI should be considered as a predictor for high cervical lymph node metastases and poor 5-year survival of early tongue squamous cell carcinoma. Elective neck lymph node dissection should be performed among patients with PNI-positive early tongue squamous cell carcinoma.
RESUMO
Introduction. Cancer of unknown primary (CUP) is histologically defined as the presence of a metastasis of lymph node without detection of the primary tumor [1]. Approximately 3–15% of all cancers are designated as CUP [3. 4]. The diagnosis, treatment and monitoring of patients with laterocervical metastases of unknown primary involves a wide range of oncologic entities [5]. While we were studying patho-histological examination of cervical lymphadenopathy in Mongolian, werevealed unknown primary tumor. This is a goal of our study. Objectives of study are followings to differentiate whether primary lymphoma or metastatic cancer of cervical lymph node metastasis of unknown primary tumor and to reveal primitive origin of tumor using by basic and additional immunohistochemical markers.Goal.To determine the conclusive diagnosis in cervical lymph node metastasis of unknown primary origin by immunohistochemical techniqueMaterials and Methods. In this study, we examined immunohistochemically 30 cases of outpatient head and neck surgical unit of the National Cancer Center and dentistry and oral maxillofacial surgical unit of the State Central Hospital which were diagnosed as cervical lymphadenopathy. For immunohistochemical study, we applied an immunohistochemical panel in accordance with avidinbiotin- peroxidase complex method and used a basic and additional antibodies represented by CK(pancytokeratin), LCA, synaptophysin, chromogranin and HMB45. Result. In our study, there was 63.3% lymphoma, 36.7% metastatic cancer. Among them, there were 4 of digestive tract adenocarcinoma, 3 of squamous cell carcinoma /2-esophagus, 1-nasopharyngeal/, 2 of neuroendocrine tumor and 1 of melanoma.Distribution by age groups shows that 20-29 years were 4(13.3%), 30-39 years were 10 (33.3%), 40-49 years were 8 (26.7%), 50-59 years were 3 (10%), over60 years were 5 (16.7%). Gender distribution showed an increased incidence of males (56.7%, 17 cases) compared with females (43.3%, 13 cases).Conclusion: In our study, B cell lymphoma and digestive tract adenocarcinoma were the most common. In further, it is necessary to introduce an immunohistochemical method in patho-histological practice.
RESUMO
PURPOSE: The management of cervical lymph node metastases from papillary thyroid cancer ranges from selective removal to a radical neck dissection. A clear understanding of the metastases of nodes at potential risk improves the quality of life (QOL) of patients, and through correct surgical methods, based on previous studies; it has been found that lymph node metastasis correlated with a high risk of recurrence. The purpose of our study was to improve the QOL of patients through an appropriate surgical method at the time of the initial operation, which decreases the risk and incidence of reoperation, by reviewing the relationship of multiple variables with cervical lymph node metastases. METHODS: We retrospectively reviewed 123 consecutive patients with papillary thyroid cancer, who underwent a total thyroidectomy with modified radical neck dissection between January 2000 and December 2001. We analysed the relationship between the metastatic pattern, age, sex, tumor location and tumor size, degree of invasion, multicentricity, duration and postoperative complications, in the patients with cervical lymph node metastases. RESULTS: Of the multiple variables, age, sex and capsular invasion were found to significantly correlate with lymph node metastases. CONCLUSION: In patients presenting with capsular invasion, modified radical neck dissections are recommended for palpable cervical lymph nodes, for the prevention of recurrence and reoperation, even when the statistics indicate significance in male patients, or those of a young age, although, further studies with a larger population are required.
Assuntos
Humanos , Masculino , Incidência , Linfonodos , Esvaziamento Cervical , Metástase Neoplásica , Complicações Pós-Operatórias , Qualidade de Vida , Recidiva , Reoperação , Estudos Retrospectivos , Glândula Tireoide , Neoplasias da Glândula Tireoide , TireoidectomiaRESUMO
Objective To investigate expression of C-MET in palliary thyroid carcinoma(PTC) detected by rapid immunohistochemical analysis and its clinical significance to predicting lymph node metastases.Methods The expression level of C-MET was examined by rapid immunohistochemical analysis with C-MET-EPOS antibody in 85 cases of PTC.Results The rate of cervical lymph node metastates in PTC with strong positive stain expression(95.0%,23/25) was significantly higher than in PTC with positive stain expression(13.4%,8/60)(P