RESUMO
Chilblain lupus erythematosus (LE) is a rare, chronic form of cutaneous LE (CLE), which presents mostly in women as erythematous to violaceous plaques on the acral areas and face, precipitated by cold and damp climates. It may be accompanied by discoid LE (DLE) lesions or other forms of CLE. Up to 20% of patients develop systemic LE (SLE). Although two missense mutations in TREX1, encoding the 3'-5' repair exonuclease 1, were described in familial chilblain LE, the pathogenesis of sporadic chilblain LE remains unknown. To our knowledge, there are a few reports of chilblain LE in the Korean dermatologic literature. Herein, we present a rare and interesting case of sporadic chilblain LE in 71-year-old man and review the Korean literatures.
Assuntos
Idoso , Feminino , Humanos , Pérnio , Clima , Temperatura Baixa , Exodesoxirribonucleases , Lúpus Eritematoso Cutâneo , Mutação de Sentido IncorretoRESUMO
Chilblain lupus erythematosus is a special, relatively rare subtype of chronic cutaneous lupus erythematosus. Usually, discoid lesions precede or occur concurrently with perniotic lesions, and about 20% of the patients later develop systemic lupus erythematosus. Herein, we present a 26-year-old female patient who developed erythematous to purplish scaly and crusted papules on the palms, fingers and toes. She also had erythematous hyperkeratotic plaques on the ears and scalp with scarring alopecia that was consistent with discoid lupus erythematosus. Histopathologic finding revealed perivascular and periappendigeal lymphocytic infiltration and fibrin deposition in dermal blood vessels. Therefore, this represents a case of chilblain lupus erythematosus which is a rare subtype and shows typical clinical and histopathologic findings.
Assuntos
Adulto , Feminino , Humanos , Alopecia , Vasos Sanguíneos , Pérnio , Cicatriz , Orelha , Fibrina , Dedos , Lúpus Eritematoso Cutâneo , Lúpus Eritematoso Discoide , Lúpus Eritematoso Sistêmico , Couro Cabeludo , Dedos do PéRESUMO
Chilblain lupus erythematosus (CLE) is a subtype of lupus erythematosus. It is characterized by cutaneous lesions located on the fingers, toes, nose, ears, elbows, heels and knees and is induced or aggravated by exposure to a cold or damp climate. Various laboratory alterations including antinuclear antibody (ANA), anti-dsDNA antibody, anti-SSA/SSB antibody, rheumatoid factor, and cryoglobulin have been reported in CLE patients. Especially, SSA/Ro antibodies may be especially associated with CLE. Approximately 20% of patients presenting with CLE later develop systemic lupus erythematosus (SLE). A 28-year-old man diagnosed with SLE presented with a 2-year history of pruritic erythematous plaques on the ears and dorsa of his hands and feet. The lesions developed or were aggravated the cold weather. In the summer, they were reported to improve, but they did not heal. ANA anti- SSA/SSB antibodies, and anti-dsDNA antibodies were found to be present. He was treated with a topical steroid and advised to avoid the cold.
Assuntos
Adulto , Humanos , Anticorpos , Anticorpos Antinucleares , Pérnio , Clima , Orelha , Cotovelo , Dedos , Pé , Mãos , Calcanhar , Joelho , Lúpus Eritematoso Sistêmico , Nariz , Fator Reumatoide , Dedos do Pé , Tempo (Meteorologia)RESUMO
Chilblain lupus erythematosus (LE) is a chronic unremitting form of LE seen predominantly in women. Chronic facial discoid LE frequently appears before the chilblain form. It may progress to systemic LE more frequently than other forms of chronic cutaneous LE do. We reported a case of chilblain LE in a 28-year-old male. He has had 1-5mm sized scaly erythematous macules on the ear, face, finger and toe tips for 10 years and these lesions have been aggravated in winter. Histopathologic findings were consistent with chilblain LE. The laboratory findings showed antinuclear antibody and anti-ds DNA antibody were positive but cryoglobulin and cold agglutinin were negative. One year later, lupus nephritis developed with leukopenia and decreased C3, C4 levels. He was diagnosed as systemic LE.
Assuntos
Adulto , Feminino , Humanos , Masculino , Anticorpos Antinucleares , Pérnio , DNA , Orelha , Dedos , Leucopenia , Lúpus Eritematoso Sistêmico , Nefrite Lúpica , Dedos do PéRESUMO
Chilblain lupus erythematsus is a rare special subtype of chronic cutaneous lupus erythematosus characterized erythematous acral skin lesion induced by cold, damp climate. Approximately, only 20% of the patients presenting with chilblain lupus erythematosus later develop systemic lupus erythematosus(SLE). We present here a case of chilblain lupus erythematosus, associated with a development of SLE later. A 29-year-old female patient has had violaceous and erythematous papules on the ear, dorsal hands and finger tips for 10 years and these lesions have been aggravated by winter. She has been diagnosed as a suspicious SLE for 3 years and then was treated with oral prednisolone and hydroxychloroqine.
Assuntos
Adulto , Feminino , Humanos , Pérnio , Clima , Orelha , Dedos , Mãos , Lúpus Eritematoso Cutâneo , Lúpus Eritematoso Sistêmico , Prednisolona , PeleRESUMO
Chilblain lupus erythematosus(CLE) is a chronic unremitting from of LE seen predomin antly in women, The chilblain lesion occurs commonly on the digits, calves and heels. Chronic facial discoid LE usually appears before the chilblain form. A 23-year-old female had relatively well defined, erythematous discoid plaques on her both cheeks and scattered erythema multiforme-like ring lesions on her right hand and right wrist. There were also chilblain lesions showing multiple, purple colored macules on her knees, lower legs and periungual areas of fingers and toes. The skin lesions developed at November, 1982 and then the skin lesions remitted during the next summer. The skin lesions recurred at December, 1983.