RESUMO
Objective: To investigate the water-soluble phenolic acids from Clerodendranthus spicatus of Dai medicine. Methods: The chemical constituents were separated and purified by D101, Sephadex LH-20, MCI, and preparative HPLC column chromatographies. Their structures were determined by physicochemical properties and spectral data analyses. Results: Sixteen constituents were isolated and elucidated as protocatechualdehyde (1), protocatechuic acid (2), 3, 5-dihydroxybenzaldehyde (3), 4-hydroxybenzoic acid (4), 4-hydroxybenzaldehyde (5), vanillic acid (6), danshensu methyl ester (7), 3, 5-O-dimethyl gallic acid (8), helisterculins A (9), lithospermic acid (10), methyl lithospermate (11), dimethy lithospermate (12), helisterculins B (13), ethyl dihydrocaffeate (14), ferulic acid (15), and dihydroferulic acid (16). Conclusion: Compounds 3, 6-9, and 13-16 are obtained from Clerodendranthus Kudo for the first time.