Study on Clinical and Laboratory Profile of Patients with Primary Hyperthyroidism

Introduction: Thyroid hormones regulate numerousmetabolic processes. Therefore, any alteration in theirsynthesis or function has important health implications. Aims:Study done on clinical and laboratory profile of patients withprimary hyperthyroidism.Material and methods: Descriptive and cross-sectionalStudy done amongst the in-patients with a proven PrimaryHyperthyroidism. 60 Patients with newly diagnosed PrimaryHyperthyroidism above the age of 18 years. Diagnostichormone levels i.e. increased SERUM T3,T4 levels withdecreased TSH levels.Results: out of 60 patients of Hyperthyroidism, 60% wereGrave’s disease, 28.3% were Toxic multinodular goiter and1.7% was toxic solitary nodule. Majority of TSH values wereless than 0.01. In all most all cases both T3 and T4 wereelevated (predominantly T4). There was no difference inT3, T4 and TSH values among the three common causes ofHyperthyroidism. Wayne’s clinical Diagnostic index had goodcorrelation with T3 (p value of 0.024), T4 and TSH. When theWayne’s index was high, T3 & T4 were also high and TSHwas low.Conclusion: Wayne’s clinical index correlate quite well withthe thyroid function tests particularly raised T3 and the scorecould be a useful tool for follow up of hyperthyroid patients

Study of Clinical and Laboratory Profile of Fever with Thrombocytopenia in Tertiary Hospital

Introduction: Fever is the most challenging problem in thefield of medicine, consists of occult manifestation of commondiseases rather than the actual diseases. An A.M temperatureof >37.2°C (98.9°F) or a P.M temperature of > 37.7°C (99.9°F)will be considered as fever. Thrombocytopenia is defined asplatelet count <150,000/µl. This is due to decreased productionof platelets, increased destruction and increased sequestrationin the spleen. Study aimed to evaluate clinical and laboratoryprofile in patients having fever with thrombocytopenia.Material and methods: A series of 100 patients admittedin SMBT Medical College and Hospital with fever andthrombocytopenia were evaluated. During the hospital stay,all the patients were subjected repeat CBC once in 2 days.Follow up of all patients regarding treatment and outcomeswere done during the hospital stay.Results: Out of 100 cases of fever with thrombocytopenia,62 were males and 38 were females. The most common causewas malaria in 38% of cases followed by dengue in 30% ofcases and septicemia in 17% of cases. Based on severity mild,moderate and severe thrombocytopenia observed in 47%, 35%and 18% respectively. Bleeding manifestations were seen in36 patients. 94 patients recovered and 6 expired.Conclusion: Fever with thrombocytopenia is one of thechallenging problems in the field of medicine. Bleedingmanifestations associated with thrombocytopenia were seenamong dengue cases. Platelet transfusions should be carriedout as per WHO guidelines. Thus a well organized systemicapproach needs to be carried out with an awareness ofdifferent causes of fever with thrombocytopenia which canhelp to diagnose and manage the case early