A five-year review of the clinicopathologic profile of patients with hydatidiform mole at the Philippine General Hospital / Philippine Journal of Obstetrics and Gynecology

Background@#The clinical presentation of patients with hydatidiform mole have changed in recent years due to earlier diagnosis as a result of widespread use of ultrasonography and availability of assays for human chorionic gonadotrophin.@*Objective@#To determine the clinicopathologic profile of patients diagnosed with hydatidiform mole at the Philippine General Hospital from January 2013 to August 2018.@*Methods@#This retrospective cross-sectional study included all patients with histologically confirmed diagnosis of hydatidiform mole managed at the Philippine General Hospital from January 2013 to August 2018. Medical records of patients were retrieved. All abstracted variables were analyzed retrospectively. The level of significance for all sets of analysis was set at p-value < 0.05 using two-tailed comparisons.@*Results@#From January 2013 to August 2018, a total of 435 patients diagnosed with hydatidiform mole were managed at the Philippine General Hospital with a prevalence rate of 15.7/1,000 pregnancies. Diagnosis was made in the first trimester in 52% of patients. A quarter of the patients had pre-evacuation B-hCG levels of more than 1 million mIU/mL. Vaginal bleeding was the most frequent presenting symptom but only 59% of the patients had anemia requiring blood transfusion. Majority (90.57%) had a histopathologic diagnosis of complete hydatidiform mole.@*Conclusion@#The prevalence and clinicopathologic profile of patients with hydatidiform mole in the Philippine General Hospital have remained largely unchanged.

Data Analysis of Ovarian Cancer Patients for Feasibility of Treatment in a Radiation Oncology Department

Introduction: Ovarian cancer is not only the most common but also the most lethal gynecological malignancy, partly, becausethe majority of patients present with advanced disease. However, as is true for so many cancers, the management of patientswith ovarian neoplasms has changed substantially, and outcome results have improved considerably over the years.The reasonsfor this are many. For example, major advances in chemotherapy have resulted in improved survival, and the role of surgeryis constantly evolving and being refined.Purpose: A retrospective data analyses of ovarian cancer patients to observe their contemporary management in a radiationoncology departmental set up and the post-treatment outcome of these patients.Materials and Methods: The case records of 117 ovarian neoplasm patients registered in our department from 2011 to 2018were analyzed. The clinical, histopathological, and treatment details were noted. Contemporary treatment protocols were used.Results: Of the 117 patients of ovarian cancer treated in our department with conventional diagnostic, imaging, surgical, andcontemporary chemotherapy protocols, we found management of such patients is possible with optimum outcomes.Conclusion: Ovarian cancer patients can safely and optimally be treated in a radiation oncology department.

Epstein-Barr virus in non-Hodgkin lymphoma of the tonsil in Indonesian patients.

Twenty cases of tonsillar non-Hodgkin lymphoma seen at the Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia during 1995-1997 were studied clinicopathologically. The specimens were analysed for routine histopathology, in situ hybridization and immunohistochemistry. The lymphoma was found mostly in the 7th decade, the median age was 57.5 year. Male to female ratio was 1:1. The hostological types were 70% of intermediate grade and 30% of high grade of malignancy. All of the lymphomas were B cell lymphomas. EBER and LMP1 were not expressed in all cases.