Barniz polimerizable de vidrio ionómero modificado con resina "clinpro xt": una alternativa de tratamiento para la sensibilidad dentaria. Revisión sistemática de la literatura

Resumen Introducción: En respuesta a la sensibilidad dentinaria, se han desarrollado múltiples productos, entre ellos, Clinpro XT, barniz de vidrio ionómero modificado con resina fotopolimerizable con flúor, calcio y fosfato. Metodología: Se realizó una revisión sistemática de la literatura. La selección fue en base a título, resumen y texto completo de acuerdo a los criterios de inclusión y exclusión. Resultados: De 299 artículos, fueron seleccionados revisiones sistemáticas, metaanálisis, estudios in vivo e in vitro y 2 encuestas. Discusión: Clinpro XT reduce la permeabilidad dentinaria, ocluye túbulos dentinarios e inhibe su reapertura, aumenta la biodisponibilidad de minerales en saliva y promueve la remineralización del esmalte. Significando una mayor protección del esmalte y dentina de forma inmediata y a largo plazo. Conclusiones: Clinpro XT demostró disminuir la hipersensibilidad dentinaria incluso después 6 meses posterior a su aplicación.

Resumo Introdução: Em resposta à sensibilidade dentinária, foram desenvolvidos múltiplos produtos, incluindo Clinpro XT, um verniz de vidro de ionómero modificado com resina fotopolimerizável com flúor, cálcio, e fosfato. Metodologia: Foi realizada uma revisão sistemática da literatura. A selecção foi baseada no título, resumo e texto completo de acordo com os critérios de inclusão e exclusão. Resultados: De 299 artigos, revisões sistemáticas, meta-análises, estudos in vivo e in vitro e 2 inquéritos foram seleccionados. Discussão: Clinpro XT reduz a permeabilidade da dentina, oclui os túbulos dentinários e inibe a sua reabertura, aumenta a biodisponibilidade dos minerais na saliva e promove a remineralização do esmalte. O que significa uma maior protecção do esmalte e da dentina imediatamente e a longo prazo. Conclusões: Foi demonstrado que o Clinpro XT diminui a hipersensibilidade da dentina mesmo 6 meses após a aplicação.

Abstract Introduction: Multiple products have been developed to treat dentin sensitivity, including Clinpro XT, a lightcuring resinmodified ionomer glass varnish with fluoride, calcium, and phosphate. Methodology: A systematic literature review was conducted. The articles were selected based on title, abstract, and full text according to the inclusion and exclusion criteria. Results: Of 299 articles, systematic reviews, metaanalysis, in vivo and in vitro studies, and 2 surveys were selected. Discussion Clinpro XT reduces dentin permeability, occludes dentin tubules, inhibits their reopening, increases mineral bioavailability in saliva, and promotes enamel remineralization. This entails greater protection of enamel and dentin immediately and in the long term. Conclusions: Clinpro XT was shown to decrease dentin hypersensitivity even six months after application.

Comparative evaluation of marginal integrity of glass ionomer and resin based fissure sealants using invasive and non-invasive techniques: An in vitro study.

Background: Occlusal surfaces of the molars are highly susceptible to dental decay. Pit and fissure sealants are one of the best methods of preventing fissure caries. The main problem encountered is microleakage leading to deterioration of material and increased possibility of the development of secondary caries. Aims: To assess and compare the marginal integrity of glass ionomer (Fuji VII) and resin based (Clinpro) fissure sealants using invasive and non-invasive technique. Setting and Design: Experimental in-vitro study. Materials and Methods: An in-vitro study was conducted on 40 healthy, extracted premolars. The teeth were divided into 4 groups. Group I: Clinpro-invasive technique, group II: Clinpro-non-invasive technique, group III: Fuji VII-invasive technique, group IV: Fuji VII-non-invasive technique. Sealants were applied and subjected to an evaluation under SEM (scanning electron microscopy) for the width of the marginal gap. ANOVA (analysis of variance) and Duncan's multiple range tests were used for the statistical analysis. Results: The mean width of the marginal gap was 0.4089 μm in group I as compared to 3.0485 μm in group III; and the difference was statistically highly significant (P<0.001). In non-invasive technique, Clinpro and Fuji VII showed a mean marginal gap width of 0.4486 μm and 3.0485 μm, respectively. This difference was statistically highly significant at a P<0.001. There was no statistically significant difference in the mean widths between invasive and non-invasive techniques. Conclusion: Clinpro performed better in terms of marginal adaptation than did the Fuji VII sealant. The techniques (Invasive and non-invasive) does not influence the marginal integrity significantly.

Proteomic profiling of nephrotic syndrome in serum using magnetic bead based sample fractionation & MALDI-TOF MS.

Background & objectives: At present, the diagnosis of nephrotic syndrome (NS) requires a renal biopsy which is an invasive procedure. We undertook this pilot study to develop an alternative method and potential new biomarkers for diagnosis, and validated a set of well-integrated tools called ClinProt to investigate serum petidome in NS patients. Methods: The fasting blood samples from 49 patients diagnosed with NS by renal biopsy, including 17 mesangial proliferative glomerulonephritis (MsPGN), 12 minimal change nephrotic syndrome (MCNS), 10 focal segmental glomerulosclerosis (FSGS) and 10 membranous nephropathy (MN), were collected and screened to describe their variability of the serum peptidome. The results in NS group were compared with those in 10 control healthy individuals. Specimens were purified with magnetic beads-based weak cation exchange chromatography and analyzed in a MALDI-TOF MS. Results: The results showed 43, 61, 45 and 19 differential peptide peaks in MsPGN, MCNS, MN and FSGS groups, respectively. A Genetic Algorithm was used to set up the classification models. Cross validation of healthy controls from MsPGN, MCNS, MN and FSGS was 96.18, 100, 98.53 and 94.12 per cent, respectively. The recognition capabilities were 100 per cent. Interpretation & conclusions: Our results showed that proteomic analysis of serum with MALDI-TOF MS is a fast and reproducible approach, which may give an early idea of the pathology of nephrotic syndrome.