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@#Objective To compare the prognosis of cognitive dysfunction in patients with cerebral hemorrhage and cerebral infarction by observing the effect of comprehensive rehabilitation intervention based on attention and working memory on the patients with cognitive dysfunction after cerebral hemorrhage and cerebral infarction.Methods A total of 44 patients with cognitive dysfunction after stroke admitted to the Rehabilitation Department of the First Hospital of Jilin University from September 2018 to January 2021 were selected，including 19 patients with cerebral infarction and 25 patients with cerebral hemorrhage，aged from 18 to 80 years，with the course of disease ranging from 2 weeks to 12 months. Both groups received cognitive training based on attention and working memory and conventional rehabilitation therapy，cognitive training 20 minutes a day,6 days/ week，for 4 weeks. Routine rehabilitation includes physical factor therapy，exercise therapy，occupational therapy，aerobic exercise，acupuncture，etc. Montreal Cognitive Assessment（MoCA） was used to assess Cognitive function in all patients before and after treatment.Results After treatment，MoCA scores of 2 groups were significantly higher than those before treatment，the difference was statistically significant（P<0.05）；The improvement of MoCA scores in cerebral hemorrhage group was higher than that in cerebral infarction group，and the difference was statistically significant（P<0.05）.Conclusion Comprehensive rehabilitation intervention based on attention and working memory can effectively improve the level of cognitive function in patients with intracerebral hemorrhage and cerebral infarction，and the prognosis of cognitive function after intracerebral hemorrhage may be better.
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Objective To explore the relationship between the levels of serum BDNF,IL-6 and Hcy with cognitive impairment in the patients with first episode schizophrenia.Methods One hundred and thirty-five patients with schizophrenia(patients group)and 130 mental healthy volunteers (control group)in our hospital from January 2015 to January 2016 were selected as the research sub-jects.The levels of IL-6 and BDNF were detected by adopting the enzyme linked immunosorbent assay (ELISA)and Hcy level was detected by using the circulating enzymatic method.The mental symptoms were evaluated by the positive and negative symptom rat-ing scale (PANSS),cognitive function was evaluated by the Wisconsin Card Sorting Test (WCST)and their relationship was ana-lyzed.Results The BDNF level in the patients group was significantly lower than that in the control group,while the Hcy and IL-6 levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The WCST errors response number,persistent errors number and total responses number in the patients group were significantly higher than those in the control group,while the complete classification number and correct response number were significantly lower than those in the control group,the differences were statistically significant (P<0.05).The levels of BDNF,IL-6 and Hcy had significant cor-relation with the WCST total responses number,persistent errors number,errors response number and complete classification num-ber.Conclusion The levels of serum Hcy,IL-6 and BDNF in the patients with first episode schizophrenia have a certain relation with the mental symptoms and cognitive function,which demonstrates the existence of nerve-humor-immune regulation network regulation mechanism in a certain degree and plays a synergic action in the occurrence and development of schizophrenia.