RESUMO
Objective To investigate the clinical value of combined measure of the serum levels of CA153,CA125,CA199 and CEA in the diagnosis of breast cancer.Methods Serum levels of CA153,CA125,CA199 and CEA in 68 patients with breast cancer,50 patients with benign breast diseases and 58 healthy volunteers were measured by electrochemiluminescence immunoassay (ECLIA).Results The levels of CA153,CA125,CA199 and CEA in breast cancer group were significantly higher than those in benign breast disease and healthy volunteers.Sensitivities of CA153,CA125,CA199 and CEA were 76.4 ％ (52/68),44.1％(30/68),35.3 ％ (24/68),29.4 ％ (20/68),respectively.The positive rate of combination of tumor markers was 94.1％ (64/68).Conclusion The combined assay of CA153,CA125,CA199 and CEA can improve the early diagnostic rate of breast cancer.