RESUMO
OBJECTIVE: To study deformation behaviors of directly compressed materials using induction tableting machine. METHODS: Eighteen types of materials, which were widely used in tablet production, were selected and compressed. Their deformation behaviors and compactability were investigated by applying classic methods involving compression models, mechanical energy and elastic stretch. RESULTS: Cellulose and copovidone with lower Py and E were ranked in high TS interval; starches with lower Py, high FES and Esp, and larger E values than cellulose, were ranked in inferior TS interval; polyols and lactose materials resembling cellulose powders in appearance of Esp and Py, were of higher E values than that of the latter and mostly ranked in intermediate interval; mineral materials with highest Py and E were ranked in inferior TS interval. CONCLUSION: Copovidone and cellulose derivatives display good plastic deformation and compactability whereas Ac-Di-Sol SD711 mainly deform elastically; starch derivatives primarily undergo plastic deformation during compaction but with high FES and relatively poor compactability; polyols and lactose materials exhibit brittle characteristics during loading and the former consolidating better; mineral materials show great resistance to break and deform and have relatively high elastic recovery.
RESUMO
OBJECTIVE: To study correlation between physical properties and compressibility and compactablility of Microcrystalline cellulose. METHODS: After determining the physical properties such as particle size distribution, moisture capacity, angle of repose, bulk density, tapped density, the powder was tableted by the Korsch XP1 at the same filling height, and data derived from heckle model, plasticity constant, cumulative elastic recovery, tensile strength and it's changes with time were evaluated. RESULTS: The physical properties of microcrystalline cellulose had great effect on its compactablility as well as cumulative elastic recovery out of die, but not on compressibility. And pressure applied correlated closely with changes of tensile strength in storage, which was intensified by the influence of water in powder on the particle size. CONCLUSION: Microcrystalline cellulose shows excellent compressibility, however, particle size reduction is able to decrease the compactability. Since the water in powder can increase particle size by changing internal structure of particles and plays a prerequisite role in lubrication and adherence, the variation of water content may weaken the compatability of microcrystalline cellulose and worsen the mechanical strength stability of tablets in storage.