RESUMO
Background: Febrile seizure is an event in infancy or childhood, usually occurring between 3 months and 5 years of age associated with fever but without evidence of intracranial infection. The aim of the study was to estimate the usefulness of neutrophil-to-lymphocyte ratio (NLR) in patients with simple and complex febrile seizures.Methods: Retrospective case control'' study was done in a paediatric in patients admitted to tertiary care hospital.' Study period'' was from January 2017 to December 2019. 200 children were analysed in the study. 100 out of 200 were under control group (febrile children without seizure). Remaining 100 were under case group (children with febrile seizure), 54 out of 100 children had'' complex febrile seizure, 46 out of 100 had simple febrile seizure. NLR ratio was done in all children.Results: Total 200 children were analysed in this study.'' High NLR ratio'' was noted among the cases (87 out of 100) compared to control (30 out of 100) p value = <0.001. Among the cases CFS had high NLR ratio compared to SFS, however p value was not significant (0.072).Conclusions: Children with febrile seizure had high NLR ratio compared to those without seizures. However no significant difference was noted between those with simple febrile seizure and complex febrile seizure'' However, larger trials are required'' to assess whether higher NLR can be taken as an independent risk factor for febrile seizure.
RESUMO
Background: Febrile seizures are one of the common reasons for emergency room visits in pediatric population affecting up to one in twenty children in various parts of the world. Though febrile seizures are commonly benign it is a source of major family distress and anxiety. Aim of the study: To compare serum ferritin level in simple and complex febrile seizures among children. Materials and methods: This case-control study was conducted at the Department of Pediatrics, Tirunelveli Medical College Hospital, Tirunelveli, from 2017-2018. All cases of febrile seizures which include both simple febrile and complex febrile seizures between the age group of 6 and 60 months were studied. Serum ferritin was estimated by the Ferritin-Turbilatex, by LAB KIT, CHEMEX, S.A. semi auto analyzer. Results: The mean average serum ferritin level in simple febrile seizures was 22.76. The mean average serum ferritin level in complex febrile seizures was 24.72. Hence, it was statistically significant that low serum ferritin is present in those with simple febrile seizures. Conclusion: Iron deficiency anemia was more frequent among children with febrile seizures than those with febrile illness alone. The result suggests that Iron deficiency anemia may be a risk factor for febrile seizures. Thus screening for IDA should be considered in children with febrile seizures. Fever can worsen the negative effect of iron deficiency anemia on the brain and a seizure can occur as a consequence. This suggests that iron-deficient children are more prone to febrile seizures.