RESUMO
Modernization of Chinese materia medica (CMM) is the main direction of development of CMM. As a complex system, CMM has the whole characteristics with multi-component, multi-channel and multi-target. However, the lack of material base of CMM and the unknown mechanism of action restrict the development of modern medicine. Strengthening the theoretical exploration of Chinese medicine components, which could improve the technical level of component preparation and promote the development of CMM component preparation, is the key to realize the modernization of CMM. This paper reviews the preparation technology of CMM component combined with components of biological pharmacy classification system for the purpose of improving the bioavailability of components based on the “component structure” theory.
RESUMO
The material base of TCM of preventing and curing diseases is an organic whole composed of many ingredients,and which has the characteristics of multi component,multi link and multi target.After many years of exploration and accumulation,the component structure theory of TCM based on the whole concept has been improved and developed.This paper systematically discussed cognition of material base of TCM and scientific connotation of innovative structural components of TCM focused on component structure theory,so as to provide strategies and methods for the research and development of modern innovative Chinese medicine preparations.
RESUMO
To analyze and compare the chemical compositions of Moutan Cortex, Paeoniae Rubra Radix and Paeoniae Alba Radix based on "component structure" theory. Thirteen batches of Moutan Cortex, 14 batches of Paeoniae Rubra Radix from different origins and 10 batches of Paeoniae Alba Radix from different origins were analyzed by HPLC-DAD method. Hierarchical cluster analysis and principal component analysis were used for analysis. The significant differences of principal component from Moutan Cortex, Paeoniae Rubra Radix and Paeoniae Alba Radix were investigated by using F test. HPLC fingerprints were established for 13 batches of Moutan Cortex, 14 batches of Paeoniae Rubra Radix and 10 batches of Paeoniae Alba Radix, and 7 glycosides and phenolic acids components were identified. Comparative study of Moutan Coetex, Paeoniae Rubra Radix and Paeoniae Alba Radix was conducted according to the results of hierarchical cluster analysis, principal component analysis and "component structure" theory. Moutan Cortex, Paeoniae Rubra Radix and Paeoniae Alba Radix have significant differences in mass fraction of major chemical components and their ratios, leading to different curative effects.
RESUMO
Bioequivalence has an important role in the new drug research, development of non-patent medicine, and post-marketing evaluation of drugs and is an essential step in the standardization and modernization of Chinese materia medica (CMM). With the acceleration of modernization of CMM, CMM preparation products made by different manufacturers differ in quality, resulting in different effects. Therefore, it is very important to strengthen the application of bioequivalent study in CMM preparation products to ensure the effectiveness and safety. In this paper, the research methods of the biological equivalence were introduced systematically, and the significance of the "component structure theory" to the study on biological equivalent of the CMM preparations has been elaborated, in order to improve the evaluation system of the biological equivalent for CMM preparations.