RESUMO
OBJECTIVE:To optimize the formula of compound xylocaine cream.METHODS:Orthogonal design was employed to optimize the amount of each component in the formula of compound xylocaine cream,and the pain threshold improvement rate in pain-relieving experiment of mice and the mice ear edema inhibition rate in the anti-inflammatory experiment served as indexes to optimize the formula,meanwhile a verification test was conducted.RESULTS:The optimized formula was as follows:xylocaine 20 g,chlorphenamine maleate 5 g,menthol 20 g,mupirocin 20 g in every 1 000 g cream.Both the pain threshold improvement rate and the ear edema inhibition rate in mice were all higher than 60%,which were up to the standard.CONCLUSION:The formula for compound xylocaine cream is reasonable,and this study provids experimental basis for clinical application of compound xylocaine cream.