Clinical Effect of Feining Paidu Decoction on Refractory Mycoplasma Pneumoniae Pneumonia in Child Patients / 中国实验方剂学杂志

ObjectiveTo observe the clinical efficacy of Feining Paidu decoction on refractory Mycoplasma pneumoniae pneumonia in child patients. MethodA randomized controlled trial （RCT） was conducted， with 96 child patients randomly divided into a control group and an observation group， each containing 48 cases. The control group received intravenous azithromycin （10 mg·kg-1·d-1） for 7 days， intravenous methylprednisolone （1 mg·kg-1·d-1） for 3 days， along with supportive treatments such as fluid infusion and antipyretics. The observation group received oral administration of Feining Paidu decoction once a day for 7 days. Changes in traditional Chinese medicine （TCM） syndrome scores， clinical efficacy， serum soluble B7-H3 （sB7-H3）， serum inflammatory factors， coagulation function， and lung imaging ［computer tomography（CT）］ scores were observed in both groups. Adverse reaction events were also recorded. ResultThe total effective rate in the observation group was 95.74% （45/47）， significantly higher than 80.43% （37/46） in the control group （Z=-3.702， P<0.01）. Compared with the results before treatment， TCM syndrome scores， lung imaging scores， sB7-H3， tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， interleukin-6 （IL-6）， D-dimer （D-D）， and fibrinogen （FIB） levels in both groups all significantly decreased after treatment （P<0.05， P<0.01）. After treatment， the observation group showed significantly better results in these indicators than the control group （P<0.05， P<0.01）. There was no statistically significant difference in thrombin time （TT） in the control group before and after treatment， while the observation group showed a significant prolongation after treatment （P<0.05）. There were no statistically significant differences in activated partial thromboplastin time （APTT） and prothrombin time （PT） between the two groups before treatment， and no serious adverse reactions occurred in either group. ConclusionFeining Paidu decoction combined with conventional treatment can alleviate inflammatory responses， improve hypercoagulable states， promote the absorption of pulmonary inflammation， and enhance the clinical efficacy of refractory Mycoplasma pneumoniae pneumonia in children.

Diode laser – A cure for obstinate oral lichen planus: A case series and review of the literature

Oral lichen planus (OLP) is a chronic T-cell mediated inflammatory disease of unknown etiology. Hence, no gold standard treatment modalities are available. Due to therapeutic challenges offered by conventional therapy, there is a need for effective alternate treatment with minimal side effects. The development of lasers has brought light to the treatment of obstinate OLP. Three cases of male patients in the age group 30–40 years complaining of a burning sensation in the mouth have been mentioned. Clinical and histopathological investigations showed typical findings of OLP. The treatment was started with conventional therapy of corticosteroids. The symptoms were assessed on the visual analog scale (VAS) and showed marked reduction but without complete alleviation. Hence, ablation of the lesion using a 980 nm soft-tissue diode laser was planned. The outcome of the treatment was successful, VAS 0 and no recurrence occurred in 11 months follow-up. The results of a 980 nm diode laser for the treatment of OLP are satisfactory and should be considered as a treatment alternative to conventional remedies

Efectividad de la ozonopuntura en pacientes con artrosis cervical / Effectiveness of ozonepuncture in patients with cervical osteoarthritis

Introducción: La artrosis vertebral es frecuente. Las causas y procesos fisiopatológicos que contribuyen a su avance son variados. Se plantea que 80 % de las personas mayores de 55 años de edad presentan alteraciones en la columna cervical. Objetivo: Evaluar la efectividad de la ozonopuntura para el alivio de síntomas y signos en pacientes con artrosis cervical. Métodos: Se realizó un estudio de intervención terapéutica en 80 pacientes con artrosis cervical, atendidos en la Consulta de Ortopedia y remitidos al Servicio de Medicina Tradicional y Natural del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, desde mayo del 2017 hasta marzo del 2019. Se dividieron aleatoriamente en 2 grupos: de estudio y de control, con 40 integrantes cada uno. Resultados: La enfermedad prevaleció en los pacientes de 50-59 años de edad, tanto del grupo de estudio como de control (35,0 y 30,0 %, respectivamente) y en el sexo femenino (85,0 % en el primero y 82,5 % en el segundo). La evolución fue buena y excelente en casi la totalidad de los integrantes del grupo de estudio. Conclusiones: La ozonopuntura fue efectiva en los pacientes con artrosis cervical y no se presentaron reacciones secundarias relacionadas con su aplicación. La evolución resultó satisfactoria y se observó una respuesta mayor en la desaparición de los síntomas y signos clínicos con la terapéutica acupuntural que con la convencional.

Introduction: The vertebral osteoarthritis is frequent. The pathophysiological causes and processes that contribute to its advance are varied. It is said that the 80 % of people over 55 years present cervical spine disorders. Objective: To evaluate the effectiveness of the ozonepuncture for the relief of symptoms and signs in patients with cervical osteoarthritis. Methods: A study of therapeutic intervention in 80 patients with cervical osteoarthritis was carried out, they were assisted in the Orthopedics Service and referred to the Traditional and Natural Medicine Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, from May, 2017 to March, 2019. They were divided at random in 2 groups: study and control groups, with 40 members each one. Results: The disease prevailed in the 50-59 age group, in both groups (35.0 and 30.0 %, respectively) and in the female sex (85.0 % in the first one and 82.5 % in the second). The clinical course was good and excellent in almost all the members of the study group. Conclusions: The ozonepuncture was effective in the patients with cervical osteoarthritis and adverse reactions related to its application were not presented. The clinical course was satisfactory and a higher response was observed in the disappearance of the symptoms and clinical signs with the acupuntural therapeutic than with the conventional one.

Conventional Phenylketonuria Treatment

Abstract Phenylketonuria (PKU) is caused by a deficient activity of enzyme phenylalanine (Phe) hydroxylase, which results in high Phe blood concentration, which is toxic to the central nervous system. The fundamental purpose of nutritional treatment is to reduce and maintain blood Phe between 2 mg/dL (120 µmol/L) and 6 mg/dL (360 µmol/L) in order to prevent neuropathogenic complications. At the same time, nutrition support must provide enough energy and nutrients to promote normal growth and development and also to avoid vitamin and mineral deficiencies. Phenylketonuria treatment must be maintained long-life and its adherence must be frequently assessed. The amount of Phe required by patients with PKU varies throughout life and must be adjusted according to individual tolerance, residual phenylalanine hydroxylase enzymatic activity, age, sex, growth rate, protein intake, and nutritional and biochemical status among others. Treatment must be done by trained personnel. It is necessary to unify treatment criteria and further research must be done.

Scrambler (Calmare) Therapy for Intractable Chronic Pain

Intractable chronic pain is a debilitative pain conditions for most patients. Unfortunately, the pain control managements currently have shown that it is not appropriate to reduce pain and limited efficacy and sometimes unfavorable in some patients. Scrambler (Calmare) therapy, used as an alternative treatment for chronic neuropathic pain recently, is a noninvasive approach to relieve pain by changing pain perception. The author reports the clinical experiences on effectiveness of Scrambler therapy for three patients with intractable pain refractory to conventional treatment.

Tratamiento rehabilitador integral en pacientes con fracturas de Colles consolidadas / Comprehensive rehabilitative treatment in patients with consolidated Colles fractures

Se realizó una intervención terapéutica en 50 pacientes con fracturas de Colles consolidadas, atendidos en el Hospital Clinicoquirúrgico Docente "Dr. Joaquín Castillo Duany" de Santiago de Cuba, en el período 2007-2008, a fin de evaluar el resultado del tratamiento rehabilitador integral. Se conformaron 2 grupos (control y de estudio) de 25 integrantes cada uno -- seleccionados de forma alterna --, quienes recibieron tratamiento convencional e integrador, respectivamente. Luego de aplicadas las escalas funcionales se evidenció mejor resultado terapéutico en los pacientes del segundo grupo, dado por menores complicaciones, mejor estado funcional de la muñeca y mano afectada y menor tiempo de recuperación.

A therapeutic intervention in 50 patients with consolidated Colles fractures; assisted in "Dr. Joaquín Castillo Duany" Teaching Clinical Surgical Hospital in Santiago de Cuba was carried out in the period 2007-2008, in order to evaluate the result of the comprehensive rehabilitative treatment. Two groups were formed (control and study groups) of 25 members each -- selected in an alternating way -- who received conventional and integrative treatment, respectively. After having applied the functional scales, a better therapeutic result was evidenced in the patients of the second group, given by smaller complications, better functional state of the wrist and affected hand and shorter time of recovery.

Comparación del LASIK convencional y el LASIK asférico en el tratamiento de la ametropía / Comparison of conventional LASIK and aspheric LASIK in the treatment of ametropia

Métodos: se realizó un estudio comparativo y prospectivo en 64 pacientes de la consulta externa del Servicio de Cirugía Refractiva del Instituto Cubano de Oftalmología Ramón Pando Ferrer. Estos fueron distribuidos aleatoriamente en dos grupos iguales para ambas técnicas. Las variables estudiadas fueron agudeza visual sin corrección y mejor corregida, aberración y sensibilidad al contraste en condiciones fotópicas...

Methods: a comparative and prospective study was conducted in 64 patients who attended the refractive surgery outpatient service of Ramon Pando Ferrer Cuban Institute of Ophthalmology. They were randomly distributed in two groups for both procedures. Several variables were studied such as: uncorrected visual acuity, best corrected visual acuity, aberration and contrast sensitivity at photopic conditions...

Linfoma MALT en diferentes localizaciones / MALT lymphoma in different locations

Se describen 3 casos de pacientes con linfoma MALT, diagnosticados, tratados y seguidos en la consulta de hematología del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora" de Santiago de Cuba, a la cual fueron remitidos por gastroenterólogos, otorrinolaringólogos y maxilofaciales de la mencionada institución. Uno de los afectados presentaba una masa tumoral gástrica y en nasofaringe, aparecida en diferentes momentos; otro un tumor linfoide en el paladar duro, que recurrió en ganglios infradiafragmáticos; y un tercero un nódulo linfoide en la glándula salival parótida unilateral, con recidiva en ganglios regionales después de haber sido extirpado. Todos experimentaron una buena respuesta clínica al inicio del tratamiento convencional, pero en 2 de ellos se confirmaron reapariciones no locales del proceso morboso.

Three cases of patients with MALT lymphoma are described, who were diagnosed, treated and followed up at the hematology department of "Saturnino Lora" Teaching Provincial Hospital in Santiago de Cuba, to which they were referred by gastroenterologists, otolaryngologists and maxillofacial specialists of that institution. One of those patients presented with a nasopharyngeal and gastric mass, which appeared at different times; another patient had lymphoid tumor of the hard palate, which recurred in infradiaphragmatic lymph nodes; and a third one had a lymphoid node in the unilateral salivary parotid gland with recurrence in regional nodes after having been removed. All experienced a good clinical response at the beginning of conventional treatment, but in 2 of them non-local recurrences of the disease process were confirmed.

Efectividad de la terapia láser en el tratamiento de las fracturas no complicadas de corona / Effectiveness of laser therapy in the treatment of non-complicated fractures of the dental crown

Los traumatismos dentales son la segunda causa de atención odontopediátrica tras la caries dental y dentro de ellos, la fracturas no complicadas son las que más frecuentemente se presentan. Esta investigación se desarrolló en Clínica Estomatológica Docente "Antonio Briones Montoto" del municipio Pinar del Río, en el periodo enero 2006 - noviembre 2007. Para ello se examinó una muestra de 40 pacientes divididos en dos grupos, un grupo control y uno estudio que se trataran convencionalmente y con terapia láser respectivamente. Esta muestra se seleccionó entre los pacientes que asistieron a consulta de urgencias, con el diagnóstico de fractura no complicada de corona y cumplían con los criterios de inclusión. Los datos fueron recogidos en tablas y tabulados por el método estadístico Chi cuadrado con un nivel de significación previamente fijado á= 0.05; esta investigación clasificó como un estudio de tipo experimental, aleatorio, longitudinal y prospectivo. Se encontró que a los 3 días de tratamiento el mayor porciento de pacientes tratados con láser presentaba alivio y remisión del dolor. El número de complicaciones al año evolución fue mucho menor en los pacientes tratados con láser que en los pacientes tratados convencionalmente.

Dental traumas are the second cause of odonto-paedriatic assistance after dental caries and among them the non-complicated fractures are the most frequent. This research was conducted at "Antonio Briones Montoto" Dental University Clinic in Pinar del Rio Municipality, during January 2006-November 2007. To carry it out a sample of 40 patients was taken dividing them into two groups, a control group and a study group, treating them with the conventional and laser therapies respectively. This sample was chosen among patients attending to emergency room having the diagnosis of non-complicated fracture of the dental crown and presenting the characteristics to be included. Data were collected in tables and tabulated using the statistical method of chi-squared with a level of significance previously fixed á=0.05, this research classified as an experimental, randomized, longitudinal and prospective study, finding in three days of treatment that the great percent of patients treated with laser presented relief and pain remission. Te number of complications at one-year evolution was minor in patients treated with laser than in those patients treated conventionally.