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Background: Cord blood lipid profile in neonates helps to screen for neonatal dyslipidaemia which is associated with long term morbidity mainly cardiovascular disease.Methods: The present study is a observational study done in government medical college, Chidambaram for a period of 2 years from October-2020 till September-2022 with 222 term and pre-term small or appropriate for gestational age (AGA) neonates using cord blood lipid profile.Results: In the present study of above mentioned 222 neonates, preterm accounts for 30.1% and term neonates accounts for 69.9%. AGA was 63.1% and SGA was 36.9%. Term AGA was 38.2%, term SGA 31.5%, preterm AGA was 24%, preterm SGA was 5.4%. Conclusions: Preterm AGA had higher cord lipid profile values compared to the term AGA neonates. Preterm SGA neonates had lower cord lipid profile of HDL, and LDL as compared to preterm AGA neonates. SGA neonates had higher total cholesterol, triglycerides and VLDL compared to AGA neonates. SGA neonates had lower LDL and HDL as compared to AGA neonates.
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Background: Early-onset atherosclerosis is a marker of future cardiovascular diseases. However, indicators of early dyslipidemia for primary prevention are generally lacking in sub-Saharan Africa. This study aimed at describing the cord blood lipid profile among apparently healthy newborns in a tertiary hospital in Southeast Nigeria, and its relationship with gestational age and birth weight.Methods: Cross-sectional study of 167 consecutively recruited apparently well newborns in a tertiary hospital whose cord blood lipid profile parameters (total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL C), low-density lipoprotein cholesterol (LDL C) and very low-density lipoprotein cholesterol (VLDL C)) were assessed using an autoanalyzer (BiOLis 24i). Lipid variables were presented with descriptive statistics whereas their relationship with gestational age and birth weight was highlighted using Spearman's rank correlation analysis. Dunnett's T3 Post Hoc analysis was used for pairwise comparisons.Results: The 167 newborns recruited included 15 (9%) moderate preterm, 46 (27.5%) late preterm and 106 (63.5%) term babies of which 79 (47.3%) were males and 88 (52.7%) were females. The number of recruited SGA, AGA and LGA were respectively 13 (7.8%), 142 (85%), 12 (7.2%). Mode of delivery was majorly vaginal delivery (69.5%) while the rest (30.5%) was by caesarean section. The median values (in mg/dL) of TC, TG, HDL C, LDL C and VLDL C were 60.0, 30.5, 29.0, 25.8 and 6.1 respectively, all within the normal international ranges. Triglycerides and VLDL-C had a moderate positive correlation with gestational age (rs = 0.4;p < 0.001) and were significantly higher in small-for-gestational-age newborns. Total cholesterol, HDL C, and LDL-C had a weak negative correlation with gestational age and birth weight (spearman rsË-0.3). Birth weight, gestational age, and paternal age were the common predictors of lipid profile variability.Conclusion: The finding of a significant relationship between lipid variables with gestational age and birth weight underscores the need to clinically interpret these given the relationship. The relationship with paternal age is another interesting finding which needs to be replicated and the mechanism(s) elucidated.
Assuntos
Peso ao Nascer , Sangue Fetal , Idade Gestacional , AteroscleroseRESUMO
Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity with dyslipidemia as an important contributing risk factor. Objective of the study was to determine whether there is an association between maternal lipid profile and the cord blood lipid profile of their newborns.Methods: This was a hospital-based Cross-sectional study on 60 mothers and their respective newborns (30 term and 30 preterm) conducted in Yenepoya medical college hospital from August to November 2019. Umbilical cord blood samples from the newborns were collected after birth and the mother's venous blood was collected in the fasting state (8hrs of fasting) before delivery. The levels of total cholesterol, triglycerides, HDL, LDL and VLDL were determined in mothers and their newborns by an enzymatic colorimetric method. Data obtained was analyzed by the SSPS software 23.0 version and Pearson's correlation was done.Results: There was a significant correlation between the mean concentration of maternal Triglycerides and the Triglycerides and HDL levels of neonates (p-value <0.05).Conclusions: There was a significant association of cord blood and maternal lipid profile, hence changes in maternal lipid levels might influence the lipid levels in the cord blood of newborns.