Medication Ideas for Depression from Wenyang Jieyu Prescription / 中国实验方剂学杂志

Depression is a complex emotional and mental disorder. The traditional Chinese medicine （TCM） methods for treating depression mainly include soothing the liver and relieving depression. Our research team proposes that depression is caused by Yang Qi deficiency and obstructed Qi movement， which are closely related to neurological and psychological changes induced by early traumatic experiences. Therefore， we suggest that the treatment should focus on warming Yang， replenishing Qi， and promoting Qi movement and have formulated Wenyang Jieyu prescription based on Erxiantang for warming yang and Xiaoyaosan for relieving depression. The experiment with the mouse model of early trauma induced by maternal separation showed that Wenyang Jieyu prescription significantly improved the mouse activity and environmental exploration， reduced the immobility time in forced swimming and tail suspension tests， alleviated the behaviors such as aversion to darkness and fear of open space， enhanced social interaction and social cognitive abilities， altered decision-making biases， reduced depression-like behaviors， and improved the decision-making patterns. Additionally， the prescription lowered the serum level of cortisol， inhibited the cortisol surge in the dexamethasone/corticotropin-releasing hormone （Dex/CRH） test， up-regulated the expression of mineralocorticoid receptor （MR） and 11β-hydroxysteroid dehydrogenase 2 （11β-HSD2） in the hippocampus， down-regulated the expression of glucocorticoid receptor （GR） and corticotropin-releasing hormone receptor 1 （CRHR1）， inhibited the methylation of GR exon 1 and the expression of DNA methyltransferase 1 （DNMT1）， and restored the negative feedback of the hypothalamic-pituitary-adrenal （HPA） axis. Furthermore， Wenyang Jieyu prescription up-regulated the protein level of brain-derived neurotrophic factor （BDNF）， elevated the levels of postsynaptic density protein 95 （PSD95） and synaptophysin （Syn）， decreased the cell apoptosis index and B-cell lymphoma （Bcl-2）-associated X （Bax）/Bcl-2 ratio， suppressed the expression of Caspase-3， and enhanced the neuroplasticity and anti-apoptotic capacity in the hippocampus. Considering the research results， related articles， and clinical experience， we conclude that depression should be treated with liver-soothing and depression-relieving herbs， which can be supplemented with spleen-invigorating and Qi-regulating herbs to alleviate depressive symptoms. The Yang-warming and kidney-tonifying herbs can be used to eliminate the root cause and prevent relapse. Additionally， the wind-dispersing herbs can be supplemented to regulate the Qi movement throughout the body， thereby enhancing the efficacy of depression-relieving treatment.

Percepción sobre el proceso de aprendizaje bajo el contexto de virtualidad en estudiantes de odontología / Perception of the learning process under the context of virtuality in dental students

El presente artículo tiene como objetivo conocer la percepción de los estudiantes de odontología sobre su proceso de aprendizaje bajo el contexto de la virtualidad. Para ello se realizó la búsqueda de artículos científicos, artículos de revisión y tesis publicadas desde el año 2020 hasta el 2023. Las bases de datos de donde se recopilaron los estudios fueron: Pubmed/MEDLINE, Scopus, SciELO, y Google Académico. Las opiniones de los estudiantes fueron positivas en su mayoría. Los aspectos positivos de la virtualidad se relacionaron a la flexibilidad de horarios, ahorro de tiempo y gastos extras; así mismo indicaron que resulta ser una manera didáctica de llevar las asignaturas teóricas. Por otro lado, los aspectos negativos se vincularon a las asignaturas clínicas y de laboratorio, señalaron que su proceso de aprendizaje durante la pandemia fue deficiente en estas materias. Sin embargo, algunos estudios demostraron que la virtualidad es una buena alternativa complementaria para los estudiantes de preclínica, debido a que los prepara para abordar al paciente con mayor confianza y seguridad. Se puede concluir que la virtualidad es un buen aliado en el aprendizaje de educación dental, algunos de los estudiantes alientan a que esta modalidad continúe a través del tiempo, sobre todo en cursos teóricos y preclínicos. La virtualidad puede seguir siendo parte de la educación dental en nuestro país, pero de ello también depende de las estrategias y metodologías de enseñanza que lo acompañen.

The objective of this article is to know the perception of dental students about their learning process under the context of virtuality. For this purpose, a search was carried out for scientific articles, review articles and theses published from 2020 to 2023. The databases from which the studies were compiled were: Pubmed/MEDLINE, Scopus, SciELO, and Google Scholar. The opinions of the students were mostly positive. The positive aspects of virtuality were related to the flexibility of schedules, time savings and extra expenses; They also indicated that it turns out to be a didactic way of carrying out the theoretical subjects. On the other hand, the negative aspects were linked to clinical and laboratory subjects; they indicated that their learning process during the pandemic was deficient in these subjects. However, some studies have shown that virtuality is a good complementary alternative for preclinical students, because it prepares them to approach the patient with greater confidence and security. It can be concluded that virtuality is a good ally in learning dental education; some of the students encourage this modality to continue over time, especially in theoretical and preclinical courses. Virtuality can continue to be part of dental education in our country, but it also depends on the teaching strategies and methodologies that accompany it.

Research ideas of core formulas-syndromes based on disease-syndrome-treatment combination / 中国中药杂志

The relationship between disease and syndrome is a research focus in integrated traditional Chinese and western medicine. Depending on the focus, the disease-syndrome combination for treatment is manifested as the different treatment methods for the same disease and the same treatment method for different diseases based on the syndrome, and different treatment methods for the same syndrome and the same treatment method for different syndromes based on the disease. The mainstream model is the combination of di-sease identification in modern medicine with syndrome identification and core pathogenesis in traditional Chinese medicine. However, current research on the combination of disease and syndrome and core pathogenesis tends to focus on the heterogeneity between disease and syndrome and the separation of syndrome and treatment. Therefore, the study proposed the research idea and model of core formulas-syndromes(CFS). According to the theory of formula-syndrome correspondence, the research idea of CFS deepens the research on core pathogenesis, which aims to summarize the core formulas and syndromes for diseases. The research fields include diagnostic criteria for the indications of formulas, distribution patterns of formulas and syndromes for diseases, the evolution of medicinal-syndrome based on formulas-syndromes, formula combination law based on formulas-syndromes, and the dynamic evolution of formulas-syndromes. Through the summary of ancient classics, clinical experience, and medical records, and with the methods of expert consultation, factor analysis, and clustering analysis, research on the diagnostic criteria for the indications of formulas aims to explore the diagnosis information such as the diseases, symptoms, signs, and pathophysiology. The research on the distribution patterns of formulas and syndromes for diseases tends to summarize the specific types of formulas and syndromes for the diseases through literature research and clinical cross-sectional studies based on the establishment of diagnostic criteria for the indications of formulas. The research on the evolution of medicinal-syndrome aims to clarify the medicinal-syndrome law through literature and clinical research. The formula combination law refers to the fact that the core prescriptions for a disease often appear in combination with other prescriptions on a regular basis. The dynamic evolution of formulas-syndromes refers to the continuous transformation and change of formulas and syndromes in the process of disease development with changes in time and space. The CFS is conducive to the unification of disease, syndrome and treatment and to the deepening of the research model of disease and syndrome integration.

Arrhythmia:innovative understanding from traditional Chinese medicine and treatment by classic herbal formulas / 中国中药杂志

Arrhythmia, a common and frequently occurring cardiovascular disease, causes a heavy burden on the public health of China. Approximately 20 million patients are suffering from this disease in China and treated by pharmacological and surgical therapies. However, antiarrhythmic drugs can cause arrhythmia and surgical treatment has the risks of failure and recurrence. Therefore, the clinical outcome of arrhythmia remains to be improved. According to the traditional Chinese medicine(TCM) theory, arrhythmia is a disease of palpitation induced by 7 conditions: liver depression and Qi stagnation, accumulation of turbid phlegm, fluid retention attacking the heart, fire-heat disturbing the heart, stasis obstruction of heart vessel, cold congealing in heart vessel, and the deficiency of Qi, blood, Yin, and Yang. Therefore, this study concisely proposed 7 TCM syndromes of arrhythmia, including the palpitation due to depression, phlegm, fluid retention, fire, blood stasis, cold, and deficiency. The corresponding treatment strategies were recommended as follows: Chaihu Longgu Muli Decoction for the palpitation due to depression, Wendan Decoction for the palpitation due to phlegm, Linggui Zhugan Decoction for the palpitation due to fluid retention, Sanhuang Xiexin Decoction for the palpitation due to fire, Xuefu Zhuyu Decoction for the palpitation due to blood stasis, and Mahuang Fuzi Xixin Decoction for the palpitation due to cold, and Guizhi Gancao Decoction, Guizhi Gancao Longgu Muli Decoction, Huanglian Ejiao Decoction, Zhigancao Decoction, and Guipi Decoction for the palpitation due to the deficiency of Qi, blood, Yin, and Yang. Multiple formulas should be combined if the patient presents several TCM syndromes simultaneously. According to the principles of the correspondence between formula and syndrome and the treatment with consideration to both pathogenesis and pathology and both herbal nature and pharmacology, this study proposed an integrated treatment model of "pathogenesis-pathology-nature-pharmacology" to enhance the clinical efficacy of classic herbal formulas in the treatment of arrhythmia.

Factores pronósticos de síndrome cardio-pulmonar y muerte por hantavirus Andes Sur: estudio de cohorte en San Carlos de Bariloche y su zona de influencia sanitaria / Prognostic factors for cardio-pulmonary syndrome and death by hantavirus Andes Sur: cohort study in San Carlos de Bariloche and health influence área

Resumen Las infecciones por hantavirus, ocurren a través de la inhalación de aerosoles provenientes de excretas de roedores infectados. Estos virus causan síndrome cardiopulmonar en el caso de la variante Andes Sur, con una mortalidad que puede alcanzar el 50%. Se presenta como casos esporádicos o en pequeños conglomerados, en los que predomina el contagio interhumano. En este estudio observacional de tipo cohorte histórica, en personas infectadas con hantavirus Andes Sur durante los años 2009 a 2019 que fueron asistidas en el subsector público de salud de San Carlos de Bariloche(Argentina), se buscó identificar factores que pudieran predecir mala evolución (síndrome cardiopulmonar y muerte). Para ello se caracterizó el riesgo para cada una de las variables y, para obtener información clave sobre las relaciones entre las mismas, se aplicó además un análisis de correspondencias múltiples. Durante el período de estudio, 38 personas fueron incluidas. La edad media fue de 35 años. Se sospechó contagio de persona a persona en 10/38 (26.8%) casos. El 21.1% (8/28) tuvo al momento del diagnóstico un síndrome pulmonar por hantavirus. Mientras que, 55.3% (21/38) lo desarrolló durante su evolución y 44.7% (17/38) de los infectados fallecieron durante la internación. La edad mayor a 15 años y la plaquetopenia, se asociaron con un mayor riesgo de progresión clínica, mientras que las formas de leves o las personas asintomáticas, el contagio persona a persona o durante un brote epidemiológico, se asociaron con un menor riesgo de muerte.

Abstract Hantavirus infections occur through the inhalation of aerosols from the excreta of infected rodents. These viruses cause a cardiopulmonary syn drome in the case of the Andes Sur variant, with a mortality that can reach 50%. It occurs in sporadic cases or in small clusters, in which interhuman contagion predominates. In this historical cohort-type observational study, in people infected with Andes Sur hantavirus during the years 2009 to 2019 who was assisted in the public health subsector of San Carlos de Bariloche (Argentina), it was sought to identify factors that could predict poor evolution (cardiopulmonary syndrome and death). For this, the risk for each of the variables was characterized and, to obtain key information about the relationships between them, a multiple correspondence analysis was also applied. During the study period, 38 people were included. The mean age was 35 years. Person-to-person contagion was suspected in 10/38 (26.8%) cases. 21.1% (8/28) presented a hantavirus pulmonary syndrome at the time of diagnosis, while 55.3% (21/38) developed it during their evolution, and 44.7% (17/38) of those infected died during hospitalization. Age over 15 years and thrombocytopenia were associated with a higher risk of clinical progression, while mild forms or asymptomatic people, person-to-person transmission, or during an epidemiological outbreak, were associated with a lower risk of death.

GNI PER CAPITA AND HAPPY PLANET INDEX - A COMPARATIVE ANALYSIS ACROSS DIFFERENT COUNTRY GROUPS

In order to assess the well-being of a country and to make comparative analysis across countries, Gross National Income (GNI) per capita is the most commonly and frequently used indicator of well-being. Apart from that, this paper discusses another well-being marker: Happy Planet Index (HPI) which is relatively new in its kind with a view of incorporating higher degree of subjectivity. For the purpose of establishing correspondence (if any) between these well-being indicators, a large number of countries are considered and grouped accordingly

Apresentando Victor Tausk / Introducing Victor Tausk / Présentation de Victor Tausk

Este artigo busca situar Victor Tausk, clássico autor da psicanálise, dentro do movimento psicanalítico a partir de análises históricas, por meio do entrelaçamento de textos. Tausk, advogado, também atuou com jornalismo e literatura, escrevendo poemas, contos e peças de teatro; conhece Freud a partir de uma crise de depressão que atravessa. A partir daí, a psicanálise passa a fazer parte de sua vida pessoal e profissional. No entanto, seu suicídio fez com que seu nome fosse parar nos limbos da história da psicanálise, como se jamais tivesse existido. Reconstruímos a biografia de Tausk, retirando-o desse lugar em que se encontrava e abordamos outros elementos necessários para constituir o mapa das posições de Tausk na história da psicanálise. Em posse desses elementos, apresentamos uma visão clara do que foram os dez anos de presença de Tausk no movimento psicanalítico de Viena. Esperamos que este artigo traga ao leitor atento um vislumbre da vida e da obra deste grande psicanalista e lhe acenda a curiosidade para buscar lê-lo.

This paper aims to situate Victor Tausk, classic author of psychoanalysis, within the psychoanalytic movement from historical analysis, through the interweaving of texts. Tausk, a lawyer, also worked with journalism and literature, writing poems, short stories, and plays; he meets Freud when he falls ill with a depression crisis. From then on, psychoanalysis became part of his personal and professional life. However, his suicide sent his name into limbo in the history of psychoanalysis, as if it had never existed. We reconstructed his biography, bring him from this place where he was and approached other elements necessary to constitute the map of his positions in the history of psychoanalysis. With these elements in hand, we present a clear idea of what were the ten years of his presence in the Vienna psychoanalytic movement. We hope that this article will bring the attentive reader a glimpse of this great psychoanalyst's life and work and spark his curiosity to seek to read him.

Cet article cherche à situer Victor Tausk, auteur classique de la psychanalyse, dans le mouvement psychanalytique à partir de l'analyse historique, à partir d'une lecture croisée des textes qui se réfèrent à lui. Tausk, formé en droit, ayant exercé dans cette profession, ayant également travaillé comme journaliste, écrivit des poèmes, des nouvelles et des pièces de théâtre. Il rencontre Freud lors d'une crise de dépression qu'il traverse. Dès lors, la psychanalyse fait partie de sa vie personnelle et professionnelle. Cependant, son suicide jette son nom dans les limbes de la psychanalyse, comme s'il n'avait jamais existé. Nous avons reconstruit la biographie de Tausk, en le retirant de ce lieu où il se trouvait et avons abordé d'autres éléments nécessaires pour constituer la charte des positions de Tausk dans l'histoire de la psychanalyse. Nous espérons que cet article apporte au lecteur attentif un aperçu de la vie et de l'œuvre de ce grand psychanalyste et suscitera sa curiosité pour chercher à le lire.

A elaboração da experiência nos escritos e na correspondência do jesuíta Diego de Torres Bollo(1551-1638) / The elaboration of experience in the writings and correspondence of the Jesuit Diego de Torres Bollo(1551-1638)

O objetivo da pesquisa é evidenciar, nos escritos e na correspondência epistolar de Diego de Torres Bollo (1551-1638), missionário jesuíta espanhol no Paraguai nas primeiras décadas do século XVII, a elaboração da experiência acercados primeiros anos de vida missionária junto às populações indígenas, nos espaços territoriais chamados de Reduções. O método é abordar a tópica da experiência relatada nos documentos pelo autor e entendida conforme as categorias interpretativas próprias da cultura jesuítica da época. No âmbito da experiência narrada, serão evidenciados os saberes psicológicos elaborados na tradição cultural da Companhia de Jesus, especialmente os saberes referentes aos afetos.

The aim of this paperis to evidence, in the writings and epistolary correspondence of Diego de Torres Bollo (1551-1638), Spanish Jesuit missionary in Paraguay in the first decades of the 17th century, the elaboration of the experience of the first years of missionary life with the indigenous populations, in the territorial spaces called Reductions. The method is to approach the topic of the experience reported in the documents by the author and understood according to the interpretative categories of the Jesuit culture of the time. In the scope of the narrated experience, the psychological knowledge elaboratedin the cultural tradition of the Society of Jesus will be evidenced, especially the knowledge related to affections.

SuJok Therapy For The Treatment Of Type 2 Diabetes

Background:Diabetes mellitus is one of the oldest characterized diseases in the world. By today diabetes has become a worldwide epidemic that is associated with the modern lifestyle, increased stress, improper nutrition or eating behaviours and lack of physical activity. Material And Methods:330 patients aged 30-76 years were administered to the study. All the metabolic marker analyses were conducted using an automated clinical chemistry analyzer (Dimension Xpand Plus, Siemens Healthcare, Germany). Random Plasma glucose levels (RPG) was taken 2-4 hours post meal.Sujok treatments were carried out by certified Sujok Therapistsaccording to the Diabetes treatment protocol (ISA R&D center, Nagpur, India).Result:A major decrease in plasma glucose levels was recorded 30 minutes after theinitial Sujoktreatment. Following 5 treatments, 70% of the patients responded in decrease in glucose levels (52.45±10.49 mg/dl) while 24% increase in glucose levels (22.2±7.4 mg/dl), 6% of the patients did not show any change in glucose plasma levels.HbA1c was monitored in the patients that undergone 3 months ofSujoktreatment.Aconsiderable decrease in the percent of HbA1c was observed in the plasma of treated patients (5.53±0.98%), in comparison to the initial level measured prior to the treatment procedure (8.13±1.29%).Conclusion:This study is a pilot study to evaluate possible effect of Sujok therapy for thetreatment of diabetes. Overall, it seems that Sujok therapy may decrease glucose levels and HbA1clevels. These results can support the efforts to de velop improved therapeutic and preventive strategies for diabetes. A following research regarding the treatment of diabetes complications by Sujok therapy is currently running with promising results.

Roll Back Stroke: The Way Forward for Physicians and Patients

The 6-lettered word "Stroke" is an ancient disease, likened Biblicallyto "666" in Revelation 13 verse 18. Globally, it is the commonestcause of acquired long-term disability. While its incidence has beendeclining in high-, low/middle-income countries (LMICs) have witnessed an increase. This increase is driven byepidemiologic-transition/modernizatio n-complex, healthcaredisparities, and increasing prevalence of vascular risk-factors. Despitethe disproportionate burden of stroke in LMICs, these countrieshave the lowest rate of access to acute reperfusion-interventions leadingto greater stroke-related morbidity /mortality. Effective primordial,primary, secondary, and quaternary prevention-strategies coordinated at all levels of care are needed to reduce stroke incidenceand poor outcomes. The World Stroke Organization (WSO) hasproposed achieving global primary prevention through 1) Population-wide approach to limiting stroke risk-factors exposure, 2) App-basedmotivational population-wide approach to mitigating stroke risk-fa cto rs, 3 ) u se of lo w-co st co mbi n at io n /po ly- p il l to tre at hypertension/dyslipidemia and 4) addressing behavioural risk-factorsthrough interventions by community health-workers.The need to set-up stroke-units, post-hospitalisation rehabilitation-centres, stroke-registers/registries, stroke-clubs, and encouragecommunity health-education, must be emphasised for optimal care inLMIC.13 Community Health Empowerment (CHE) withthe AcronymBE FAST / STRoke as warning signs of stroke must be emphasised(B: Balance-loss; E: Eye vision-loss; F: Facial Asymmetry; A: Armweakness; S: Speech difficulties; T: Time is brain; Or first 3-lettersof STRoke ­ Can Patient Smile? Talk? Or Raise-arm?). Strokehemorheology/blood-flow and treatment involve 3Ps' of pathogenicprinciples/strategies (Passenger, Passage, Power). Its complicationsinclude the 10D's: Death, Disability, Depression, Dementia, Delirium,Dysphagia, Dehydration, Deep-Venous Thrombosis, Decubitus-ulcers, Dysphasia, Seizures.

Exploration on Syndrome Types and Metabolic Markers of Rat Model with Heart Failure Caused by Transverse Aortic Constriction Based on Theory of Correspondence of Prescription and Syndrome / 中国实验方剂学杂志

ObjectiveTo observe the difference in the efficacy of three kinds of traditional Chinese medicine （TCM） injections on rat model of heart failure induced by transverse aortic constriction （TAC）， explore the TCM syndrome of the model based on the theory of correspondence of prescription and syndrome， and reveal the biological basis of prescription-syndrome from the perspective of metabolism. MethodRats were treated with TAC for modeling and were divided into Shenmai injection group （6.0 mL·kg-1）， model group， Danhong injection group （6.0 mL·kg-1）， Shenfu injection group （6.0 mL·kg-1） and trimetazidine group （10 mg·kg-1）， and sham operation group was set up as control. After drug intervention for 15 days， echocardiography， serum N-terminal pro-brain natriuretic peptide （NT-proBNP） and myocardial histopathological staining were performed for each group， so as to compare the efficacy to select the effective injection. Colorimetry was used to detect the serum glucolipid metabolism after the intervention of the effective injection， and ultra high performance liquid chromatography-mass spectrometry was used to observe the metabolites and related metabolic pathways in myocardial tissue. ResultCompared with the sham operation group， the left ventricular ejection fraction （LVEF） and left ventricular fractional shortening （FS） in the model group decreased （P<0.01）， while the left ventricular end-diastolic diameter （LVIDd）， left ventricular internal diameter at end-systole （LVIDs） and NT-proBNP level increased （P<0.01）. Compared with model group， LVEF and FS increased （P<0.01）， LVIDd， LVIDs and NT-proBNP level decreased （P<0.05， P<0.01） in Danhong injection group， NT-proBNP level in Shenfu injection group decreased （P<0.05）， LVIDd and NT-proBNP level increased （P<0.05， P<0.01） in Shenmai injection group， in trimetazidine group， LVEF and FS increased （P<0.01）， while LVIDs and NT-proBNP level decreased （P<0.05， P<0.01）. Serum glucose， low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels in Danhong injection group and trimetazidine group were adjusted by callbacks （P<0.01， P<0.05）. There were the callback of 9 myocardial metabolites in Danhong injection group， including glycine， serine and threonine metabolism， glyoxylate and dicarboxylate metabolism， glycerol phospholipid metabolism. There were the callback of 10 myocardial metabolites in trimetazidine group， including glycerol phospholipid metabolism. ConclusionThe efficacy of Danhong injection on heart failure model induced by TAC is significant and superior to Shenfu injection and Shenmai injection， suggesting that the model is closely related to heart-blood stasis. The biological mechanism of Danhong injection interfering with the model involves regulating the metabolic disorder of lipid， glucose， amino acid and butyric acid.

Study on related factors and effect relationship of hyperuricemia in health check-up participants / 中华内分泌代谢杂志

Objective:To investigate the influencing factors of hyperuricemia(HUA) and explore early intervention of metabolic diseases.Methods:A total of 70 523 participants were selected from the database of check-ups in 2016. Univariate analysis and logistic regression analysis were used to identify related factors of HUA. Correspondence analysis was performed for the aggregation of different levels of uric acid(UA) and related factors. The mediating effect of mean blood pressure(MBP) between abnormal metabolic indicators and abnormal renal function was tested.Results:The age, sex, occupation, body mass index(BMI), systolic blood pressure, diastolic blood pressure, blood urea nitrogen(BUN), creatinine(Cr), estimated glomerular filtration rate(eGFR), fasting plasma glucose(FPG), total cholesterol(TC), triacylglycerol(TG), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol, plasma viscosity were significantly related to HUA( P<0.001). Logistic regression analysis showed that youth, male, hypertension, TC, TG, and Cr were risk factors for HUA, while HDL-C was a protective factor for HUA( P<0.001). Correspondence analysis showed that during the gradual increase of UA, TC was the first to appear abnormal, followed by hypertension and TG, and the increase of Cr appeared last. Mediating effect showed that in changes of UA, the mediating effects of MBP on TC, TG, and HDL-C were 36.35%, 12.63%, and 9.41%, respectively. In changes of eGFR, the mediating effects of MBP on TC, TG and HDL-C were 30.20%, 27.70%, and 6.13%, respectively. Conclusions:UA is positively correlated with blood pressure, TC, and TG, and inversely with HDL-C. TC and TG have an impact on renal impairment, in which MBP plays a mediating role.

Evaluación de la variabilidad fenotípica en Simarouba amara Aubl., mediante descriptores cualitativos y cuantitativos / Assessment of phenotypic variability in Simarouba amara Aubl., through qualitative and quantitative descriptors / Avaliação da variabilidade fenotípica em Simarouba amara Aubl.,usando descritores qualitativos e quantitativos

Resumen Dentro de las estrategias de evaluación de especies forestales nativas por parte de la Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, se encuentra la caracterización fenotípica. Con el propósito de validar el uso de descriptores morfológicos y determinar la variabilidad fenotípica de la colección de trabajo del Centro de Investigación La Libertad ubicado en el piedemonte llanero (Villavicencio, Meta); se evaluaron 121 individuos de machaco (Simarouba amara Aubl.) de 6.2 años de edad, por medio de 34 descriptores de planta, hoja y fruto. Los datos cualitativos y cuantitativos se analizaron mediante análisis de correspondencias múltiples y análisis de componentes principales respectivamente, con el fin de reducir la dimensionalidad de los datos, seguido de análisis de conglomerados, utilizando el algoritmo de WARD para el agrupamiento de los individuos. Los resultados obtenidos permitieron identificar que el volumen de tronco presentó la mayor variabilidad (31.13%) y las variables cuantitativas asociadas al tamaño y diámetro de la copa, diámetro de fuste, volumen del tronco, longitud y ancho de la hoja, altura total y de copa presentaron las mayores correlaciones con los tres primeros componentes principales (57.82%). Se obtuvieron nueve conglomerados que reúnen el 95.73% de la variabilidad original y en los cuales se encontraron individuos potencialmente útiles con fines maderables, arboricultura y sistemas agroforestales. La forma del fuste, la altura de ramificación y de bifurcación, el tipo de corteza y el hábito de fructificación presentaron mínima variación en los individuos, contrario a la rectitud del fuste y la forma de la copa.

Abstract Phenotyping is one of the strategies used by Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA) for evaluating native forest species. One hundred and twenty-one 6.2 year-old mountain damson/stavewood/bitterwood/paradise trees (Simarouba amara Aubl. commonly known as machaco in Colombia) were evaluated using 34 plant, leaf and fruit descriptors to validate the use of morphological descriptors and determine the phenotype variability of AGROSAVIA's La Libertad Research Centre's working collection. The centre is located in the foothills of Colombia's eastern plains (Villavicencio, Meta). Multiple correspondence analysis (MCA) was used for analysing qualitative data and principal component analysis (PCA) for +data to reduce dataset dimensionality; this was followed by cluster analysis, using Ward's method (minimum variance method or Ward's minimum - agglomerative algorithm) for hierarchical cluster analysis for grouping the trees. The results led to identifying that the wood volume descriptor had the greatest variability (31.13%) and the quantitative variables associated with crown size and diameter, stem diameter, trunk volume, leaf length and width, total and crown height had the greatest correlation with the first three components (57.82%). Nine clusters were obtained (accounting for 95.73% of original variability) and in which trees were found for timber, arboriculture and agroforestry system purposes. The trees' stem shape, branch height and bifurcation, the type of bark and fruiting habits had minimum variation, contrary to the that found regarding stem straightness and crown shape.

Resumo Dentro das estratégias de avaliação de espécies florestais nativas pela Colombian Agricultural Research Corporation - AGROSAVIA, está a caracterização fenotípica. A fim de validar o uso de descritores morfológicos e determinar a variabilidade fenotípica da coleção de trabalhos do Centro de Pesquisa La Libertad localizado no sopé da planície, (Villavicencio, Meta); 121 indivíduos de machaco (Simarouba amara Aubl.) de 6,2 anos de idade foram avaliados por meio de 34 descritores de planta, folha e fruto. Os dados qualitativos e quantitativos foram analisados por meio da análise de correspondência múltipla e da análise de componentes principais, respectivamente, a fim de reduzir a dimensionalidade dos dados, seguida da análise de cluster, por meio do algoritmo WARD, para agrupamento dos indivíduos. Os resultados obtidos permitiram identificar que o volume do tronco apresentou a maior variabilidade (31,13%) e as variáveis quantitativas associadas ao tamanho e diâmetro da copa, diâmetro do caule, volume do tronco, comprimento e largura da folha, total a altura e a copa apresentaram as maiores correlações com os três primeiros componentes principais (57,82%). Foram obtidos nove aglomerados que atendem a 95,73% da variabilidade original e nos quais foram encontrados indivíduos potencialmente úteis para fins madeireiros, arboricultura e sistemas agroflorestais. O formato do caule, a altura da ramificação e bifurcação, o tipo de casca e o hábito de frutificação apresentaram variação mínima nos indivíduos, ao contrário da retidão do caule e do formato da copa.

Teorias da identidade e correspondência identitária / Theories of identity and identity correspondence / Teorías de la identidad y correspondencia identitaria

Este trabalho apresenta as diversas teorias sobre identidade que contribuem para a construção do conceito de correspondência identitária. Correspondência identitária é um conceito que pretende abarcar os processos de alinhamento e congruência entre os referentes identitários das dimensões pessoal, social e coletiva de identidade individual. A psicanálise, o cognitivismo social, o interacionismo simbólico e os estudos culturais são as diferentes matrizes teóricas que subsidiam sua a elaboração. Aspectos específicos do fenômeno identitário são abordados por teorias específicas. O conceito de correspondência identitária propõe uma abordagem que relacione diferentes perspectivas teóricas presentes no campo. São apresentados, neste trabalho, as possíveis contribuições dessas teorias e os limites de sua apropriação para a elaboração do conceito de correspondência identitária.

This paper presents the several theories about identity that contribute to the construction of the concept of identity correspondence. Identity correspondence is a concept that intends to encompass the processes of alignment and congruence between the identity referents of the personal, social and collective dimensions of individual identity. Psychoanalysis, social cognitivism, symbolic interactionism and cultural studies are the different theoretical foundations that subsidize its elaboration. Specific aspects of the identity phenomenon are addressed by specific theories. The concept of identity correspondence proposes an approach that relates different theoretical perspectives present in the field. This paper presents the possible contributions of these theories and the limits of their appropriation for the elaboration of the concept of identity correspondence.

Este trabajo presenta las diversas teorías sobre identidad que contribuyen a la construcción del concepto de correspondencia identitaria. La correspondencia identitaria es un concepto que pretende abarcar los procesos de alineamiento y congruencia entre los referentes identitarios de las dimensiones personal, social y colectiva de la identidad individual. El psicoanálisis, el cognitivismo social, el interaccionismo simbólico y los estudios culturales son las diferentes matrices teóricas que subsidian su elaboración. Los aspectos específicos del fenómeno identitario son abordados por teorías específicas. El concepto de correspondencia identitaria propone un abordaje que relacione diferentes perspectivas teóricas presentes en el campo. Se presentan en este trabajo las posibles contribuciones de esas teorías y los límites de su apropiación para la elaboración del concepto de correspondencia identitaria.

A comparison of the Barthel Index with functional independence measures for assessing ability in the activities of daily living after a stroke / 中华物理医学与康复杂志

Objective:To observe the relationship between extended Barthel index (EBI) values and functional independence measures (FIMs) in quantifying the ability in the activities of daily living (ADL) of stroke survivors.Methods:Eighty-six stroke survivors′ ADL ability was assessed using the FIM and the EBI and the results were compared.Results:The inter-rater reliability (ICC) of the EBI was 0.866 and the Spearman correlation coefficient relating the EBI and FIM results was 0.972. The 4 ADL functional levels of the EBI were strongly correlated with the 8 ADL functional levels of the FIMs ( χ2=187, P≤0.001). The complete dependence and extreme dependence ratings of the FIMs (18-35 points) corresponded to the EBI′s " completely needed" . Severe and moderate dependence (36-71 points) corresponded to a lot of help needed. Mild dependence, conditional independence or very mild dependence (72-107 points) corresponded to some help needed. Basic independence and complete independence (108-126 points) corresponded to self-care. Conclusions:The EBI has high reliability and good validity, and its 4 ADL functional levels correspond well with the FIMs′ 8 ADL function levels. The EBI has good clinical applicability.

Research progress of microstrabismus / 国际眼科杂志(Guoji Yanke Zazhi)

@#Microstrabismus is a kind of small angle strabismus, sometimes negative in cover test, accompanied by clinical characteristics such as abnormal retinal correspondence, eccentric fixation, amblyopia and rough stereopsis. Microstrabismus amblyopia treatment is very difficult, especially in eccentric fixation. In daily diagnosis and treatment, the microstrabismus often misdiagnosed due to the small squint degree and the negative coverage test, failed to be treated properly and in-time, the patient's eccentric fixation and fixation instability also been ignored, treated as normal amblyopia, while the result is not effective, sometimes even leads opposite effect, so it's important to recognize the microstrabismus.

Application of Correspondence Analysis in the Analysis of Accidental Death of Chinese Residents / 法医学杂志

Objective To study the preference relation between residence, sex, age and causes of accidental death of Chinese residents. Methods In this study, 72 residence-sex-age groups and 8 causes of accidental death were qualitatively and quantitatively analyzed by correspondence analysis using the official statistical yearbook issued from 2014 to 2018, and the preference values were calculated. Results Among the 576 pairs of correspondences between the residence-sex-age groups and causes of accidental death, 352 pairs （61.11%） showed a preference relation （preference value>0）. In terms of residence and sex, accidental death preference among Chinese residents was higher in rural areas than in urban areas, and males were higher than females. In terms of the causes of accidental death, the overall risk of accidental mechanical asphyxia and motor vehicle accidents was the highest among all age groups of Chinese residents. In terms of age, with the increase of age, the preference value of accidental death of Chinese residents showed a trend of first increasing and then decreasing. The comparative analysis results of the preference values of various causes of accidental death in different age groups showed that motor vehicle traffic accidents, accidental poisoning, death by crush and electric shock were more likely to occur in the working age group between 20 and 59 years old, accidental fall and fire were more likely to occur in the elderly group over 80 years old, and drowning and accidental mechanical asphyxia were more likely to occur in the minor group between 1 and 19 years old. Conclusion There are different preference relations between residence-sex-age groups and causes of accidental death in China. Therefore, effective control strategies and measures should be formulated for Chinese residents with preference for accidental death.

Epidemiologia e avaliação de risco associado à presença de ácaros hematófagos em galpões de granjas avícolas de postura / [Epidemiological and risk assessment associated with the presence of hematophagous mites in poultry farms]

Este estudo teve como objetivo caracterizar a epidemiologia da presença de ácaros hematófagos em granjas de postura no estado de Minas Gerais. Foi utilizado um banco de dados secundário, com informações de 402 galpões de 42 propriedades comerciais. As variáveis utilizadas para compor o modelo de correspondência foram selecionadas por meio do teste qui-quadrado (P≤0,05). Foi construído um índice para a presença de ácaros hematófagos, considerando alguns fatores de risco. Além disso, um estudo da análise espacial foi realizado para avaliar a presença de ácaros hematófagos em Minas Gerais. Observou-se a presença de ácaros hematófagos em 48% dos galpões, sendo a de O. sylviarum de 45,5%, O. bursa de 17,4% e D. gallinae de 2,7%. Houve associação entre o índice de risco com os intervalos de remoção de fezes e com a presença ou a ausência de aves sinantrópicas. Verificou-se que granjas mais tecnificadas não utilizam acaricida em seus galpões. A presença de ácaros hematófagos foi observada na mesorregião Sul/Sudoeste de Minas Gerais e entre as mesorregiões Oeste de Minas e Metropolitana de Belo Horizonte. Esses resultados fornecem conhecimento sobre a epidemiologia desses ectoparasitos e podem contribuir na tomada de decisões, reduzindo os riscos de possíveis infestações em aves de postura.(AU)

This study aimed to characterize the epidemiology of the presence of hematophagous mites in posture farms in the state of Minas Gerais. Was used a secondary database with information from 402 chicken houses in 42 commercial properties. The variables used to compose the correspondence model were selected through chi-square tests (P≤0.05). A risk index was built to the presence of hematophagous mites considering some risk factors. Additionally, a study of the spatial analysis was done to evaluate the presence of hematophagous mites in Minas Gerais. Was observed the presence of hematophagous mites in 48% of chicken houses, the presence of O. sylviarum was 45.5%, O. bursa 17.4% and D. gallinae 2.7%. There was an association between the risk index with the intervals for the removal of manure and the presence or absence of synanthropic birds. It was verified that more technified farms do not use acaricide in their chicken houses. The presence of hematophagous mites was observed in the Messoregions South/Southwest of Minas Gerais and between the West and Metropolitan Mesoregion of Belo Horizonte. These results provide knowledge about the epidemiology of these ectoparasites and may contribute to decision making by reducing the risks of possible infestations in poultry.(AU)

Identification, characterization and mapping of honey bee flora of Al-Baha region of Saudi Arabia

Aim: The study aimed to identify and document major honey bee flora, their blooming seasons (floral calendar), density and frequency, beekeeping potential areas, and place radius for the major bee flora of the Al-Baha region.Methodology: To identify the honey bee flora of al-Baha region, 420 quadrates were established in different seasons and ecological zones. Plants as honey bee forages were identified through observation of the foraging of honey bees on the flowers for nectar or/and pollen. The density and frequency of each plant was calculated, density and radius maps for major honey bee plants were made using the Arc-Map. Canonical Correspondence Analysis (CCA) was carried out for major honey bee plants using MVSP software. Results: The results showed that more than 550 species of flowering plants were recorded in the study areas, of which 204 plant species belonging to 58 families were identified as honey bee plants. However, only 9 species were found to be an important source of major honeys in the region. The largest number (13%) of honey bee plants was recorded for the family Asteraceae, followed by Lamiaceae, Euphorbiaceae, Fabaceae and Mimosaceae each with 13 (6.4%), 11 (5.4%), 11 (5.4%) and 10 (4.9%) plants, respectively. Each of the remaining families had 1 to 8 species. Interpretation: The radius maps, as well as the blooming periods of honey bee flora will guide beekeepers to move their colonies during the peak flowering periods

Socio-economic and technological typology of avocado cv. Hass farms from Antioquia (Colombia) / Tipologia socioeconômica e tecnológica do abacate cv. Granjas Hass de Antioquia (Colômbia)

ABSTRACT: A typology of avocado cv. Hass farms was constructed based on information collected from productive units in Antioquia, Colombia. The study aimed to provide key information about the farms for those involved in the design of programs and public policies directed to growers. The data were scrutinized through Multiple Correspondence Analysis (MCA) and Cluster Analysis. The sample was made up of 214 growers of the crop. Quantitative and qualitative variables were employed for the MCA, which rendered 40 dimensions, out of which 16 accounted for 70% of the total inertia (variance) found in the data. These 16 dimensions were used as input for the Cluster Analysis, which provided the following results: 52%, 32% and 15% of the farms were located in Clusters 1, 2 and 3, respectively. The identified farm types can be associated to peasant (Cluster 1) and commercial (Cluster 3) agricultural schemes, plus a transition between them (Cluster 2). The most discriminating variables regarding such categorization were: farm size, farm registry at ICA (Colombian Agricultural Institute), Avocado cv. Hass yield, labor source, presence of crops other than avocado, existence of formal commercial alliances and technical assistance type. The percentage of farmers belonging to grower organizations was high in the three clusters. Growers in Clusters 3 and 2 had established formal commercial alliances which enabled them to access better sale prices for the crop. A trend towards establishing cv. Hass as a monocrop is observed, which may threaten both crop biodiversity and the food security of peasant growers.

RESUMO: Uma tipologia de fazendas produtoras de abacate cv. Hass foi realizada a partir de informações levantadas em unidades produtivas no departamento de Antioquia, Colômbia. O objetivo do estudo foi fornecer informações importantes sobre as fazendas produtoras da variedade de abacate Hass, com o intuito de apoiar a elaboração de programas e políticas públicas destinados aos produtores desta variedade. Métodos estatísticos multivariados como Análise de Correspondência Múltipla (ACM) e Análise de Clusters foram utilizados. A amostra foi composta por 214 produtores de abacate cv. Hass. Variáveis ​​categóricas de tipo quantitativo e qualitativo foram utilizadas no ACM, o que permitiu a obtenção de 40 dimensões, das quais 16 continham 70% da inércia total (variância) presente nos dados. As 16 dimensões serviram como entrada para a Análise de Clusters, a qual produziu os seguintes resultados: 52%, 32% e 15% das fazendas estiveram localizadas nos Clusters 1, 2 e 3, respectivamente. Os tipos de fazendas identificados podem ser associados a esquemas de agricultura camponesa (Cluster 1), agricultura comercial (Cluster 3), e uma transição entre elas (Cluster 2). Variáveis ​​como a fonte de trabalho, a presença de culturas diferentes ao abacate, a existência de alianças comerciais formais e o tipo de assistência técnica recebida são as mais diferenciadas em relação a esta categorização. A percentagem de produtores pertencentes a organizações de produtores foi alta nos três clusters. Os produtores dos Clusters 3 e 2 estabeleceram alianças formais de negócios, o que lhes permitiu ter acesso a melhores preços de venda da cultura. Há uma tendência a estabelecer o abacate cv. Hass como uma monocultura, o que pode ameaçar tanto a diversidade da agricultura quanto a segurança alimentar dos produtores camponeses.