RESUMO
OBJECTIVE: To study the chemical constituents from Periplaneta americana. METHODS: The 95% enthanol extract was isolated and purified by column chromatography on silica gel, Sephadex LH - 20, ODS and semi-PHPLC. All compounds were identified by chemical and spectral analyses. RESULTS: Fourteen compounds were isolated and purified from Periplaneta americana. Their structures were elucidated as salicylic acid (1), benzoic acid (2), phenylacetic acid (3), methyl 4-hydroxyphenylacetate (4), p-hydroxybenzoic acid (5), genistein (6), 3-hydroxybenzoic acid (7), methyl N-(2-hydroxybenzoyl) glycinate (8), 2, 5 -dihydroxybenzoic acid (9), (2-hydroxybenzoyl) glycine (10), uracil (11), cyclo(Val-Ala) (12), N-acetyldopamine (13), and cyclo( L-Pro-L-Tyr) (14), respectively. CONCLUSION: Compounds 2, 4, 7 - 10, 12 and 14 are obtained from this genus for the first time.