Estimación de la tasa de filtración glomerular en adultos mayores mediante las ecuaciones CKD-EPI / Estimate of the glomerular filtration rate in aged adults through the CKD-EPI equations

Introducción: La tasa de filtración glomerular se considera el mejor índice para evaluar la función renal, ya que su reducción aparece mucho antes que cualquier manifestación clínica derivada de la disfunción renal. Métodos: Se realizó un estudio observacional, descriptivo y transversal de 92 pacientes sin enfermedad renal y con esta, atendidos en el Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, de febrero a noviembre de 2017, a fin de evaluar las ecuaciones insuficiencia renal crónica-colaboración epidemiológica (CKD-EPI) para estimar el filtrado glomerular en adultos mayores. Resultados: Se halló menor promedio de filtrado con orina de 24 horas en el grupo sin nefropatía (64,8 mL/min) y mayor en el grupo de nefrópatas (25,8 mL/min) respecto a dichas ecuaciones. Aunque no hubo diferencias significativas en el filtrado según edad, sexo y peso corporal, en ambos grupos al emplear CKD-EPI, los valores mayores se obtuvieron con CKD-EPI cistatina C. Conclusiones: En los ancianos sin marcadores de daño renal la utilización de las fórmulas CKD-EPI con cistatina permite una mejor estimación de la función renal.

Introduction: The glomerular filtration rate is considered the best index to evaluate the renal function, since its reduction is evidenced much time before any clinical manifestation which derives from the renal failure. Methods: A descriptive, cross-sectional and observational study of 92 patients without and with renal disease, assisted in Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, from February to November, 2017, was carried out in order to estimate glomerular filtrate in older adults by means of the CKD-EPI equations. Results: Lower average filtrate with 24 hours urine was found in the group without nefropathy (64.8 mL/min) and it was higher in the kidney disease group (25.8 mL/min) regarding these equations. Although in both groups there were no significant differences in the filtrate according to age, sex and corporal weight, when using the equations CKD-EPI, the higher values were obtained with CKD-EPI cystatine C. Conclusions: The use of the formulas CKD-EPI with cystatine allows a better estimate of the renal function in aged patients without markers of renal damage.

Clinical Investigation for Blood Levels of Cystetine C and Superoxide Dismutase in Patients With Obstructive Sleep Apnea Syndrome Related Hypertension / 中国循环杂志

Objective: To observe blood levels of cystetine C (Cys C) and superoxide dismutase (SOD) in patients with obstructive sleep apnea syndromes (OSAS) related hypertension (HP). Methods: A total of 102 HP patients received polysomgography (PSG) in our hospital from 2013-01 to 2013-12 were studied. According to apnea hypopnea index (AHI), the patients were divided into 2 groups: OSAS with HP (OH) group, n=55 patients with AHI≥5 and HP group,n=47 patients with AHI0.05. Conclusion: Blood levels of Cys C in OH and HP groups were higher than Control group, Cys C in OH group was higher than HP group; SOD levels in OH and HP groups were lower than Control group, SOD in OH group was lower than HP group. The relationships between Cys C, SOD and OH severity were unclear.