Effects of Dexamethasone on Neurogenic Bladder in Experimental Autoimmune Encephalomyelitis Rat

OBJECTIVE: We studied effects of dexamethasone on neurogenic bladder and paralysis in experimental autoimmune encephalomyelitis (EAE) rat model for multiple sclerosis. METHOD: Thirty-five female Lewis rats were used in the study. Thirteen rats used as normal cystometrogram controls. Twenty-two rats induced EAE were divided into two groups: ten rats as control and twelve rats as dexamethasone injection group. Bladder dysfunction by cystometrogram, severity of weakness, and duration of paralysis were evaluated every other day after the onset of paralysis. RESULTS: Dexamethasone injection group compared to control group presented short duration of bladder dysfunction (2.5 vs. 4.2 day, p0.05), but it was not statistically significant. CONCLUSION: Dexamethasone ameliorates the course of paralysis and bladder dysfunction in EAE. We suggest that dexamethasone treatment is an effective method in treating neurogenic bladder and paralysis in multiple sclerosis.

Availability of Cystometrogram as a Predictive Factor of Recurrence of Acute Urinary Retention by Benign Prostatic Hyperplasia

PURPOSE: We evaluated the value of cystometrogram (CMG) as a predictive factor of recurrence of acute urinary retention (AUR) in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: 26 patients attending the emergency room or out patients clinic with AUR were assessed. Indwelling catheter was placed in the bladder for 7 days and CMG was performed within 24 hours and 7 days later of AUR. Recurrence was evaluated by medical records or telephone interview after 1 year of AUR. RESULTS: CMG findings performed just after AUR were normal (7), decreased capacity (12), large capacity (4), detrusor overactivity (2) and poor compliance (1). These findings were changed by 7-days-inwelling catheterization. Decreased capacity (12) was changed to normal in 5, unchanged in 7. Large capacity (4) were changed to normal in 3, unchanged in 1, detrusor overactivity (2) and poor compliance (1) were unchanged. AUR was recurred in 5 (33.3%) out of 15 patients who showed normal (7) and turned to normal after 7-days-indwelling catheterization (8), but in 7 (63.6%) out of 11 patients whose CMG was not changed by 7-days-indwelling catheterization. CONCLUSION: Patients who showed normal at initial CMG and turned to normal CMG after 7-days-indwelling catheter were at low risk of recurrence of AUR. Therefore, CMG performed at the time of AUR may be helpful in the prediction of recurrence of AUR.

Voiding Dysfunction associated with Herpes Zoster / 대한비뇨기과학회지

PURPOSE: Herpes zoster infection involving the lumbosacral dermatomes may cause voiding dysfunction. In this study, we investigated the clinical features and urologic manifestations in patients suffering from voiding dysfunction caused by herpes zoster infection. MATERIALS AND METHODS: We have reviewed the whole medical records in 5 patients who showed voiding dysfunction concomitant with herpes zoster infection. RESULTS: Dermatome levels of zoster infection were thoracic in 1, lumbar in 1 and sacral in 3 patients. Urologic symptoms were acute urinary retention in 4, who showed detrusor areflexia in the cystometrogram, and cystitis-like symptom with detrusor hyperreflexia in 1 patient. 3 of five patients showed weak anal tonus and constipation. 4 patients who showed detrusor areflexia were managed by indwelling catheter or clean intermittent catheterization with alpha-blocker and 1 patient who showed detrusor hyerreflexia was managed by anticholinergics. The mean time of recovery from voiding dysfunction was 2.2weeks(range:1-5weeks). CONCLUSIONS: Herpes zoster infection should be considered in patients presenting with an acute neurogenic bladder of unknown cause. However, the prognosis is favorable and most of the patients regain normal bladder function within 2 weeks.