Positive Impact of Aachar-Rasayana on Health

The first and foremost aim of Ayurveda - “Swasthasya Swasthya Rakshanam Aaturasya Vikara Prashamanam Cha” is to maintain a healthy state of life and to remain free from the burden of diseases and sufferings so as to accomplish the ultimate goal of human life. To achieve this objective, Ayurveda has advocated certain percepts and rules which can ensure the normal functioning of human body without any hindrance. Ayurveda has suggested schedules of Swasthvritta including Dincharya, Ratricharya, Ritucharya, Rasayana, and Sadvritta as some of the practices and methods that leads to a happy, healthy and long life. In Ayurveda general principles to prevent psychic disturbances, practices preventing psychosomatic disturbances, practices regarding codes of general ethics in diet, behaviour, study, self-control etc. are explained as parts of Sadvritta. True efforts made for the observation of these schedules and conduct give rise to the effects of rejuvenation therapy called Aachar Rasayana that promotes longevity without any attack of diseases. Rasayana is one of the comprehensive disciplines of Ayurveda, which comprises a specialized use of herbs, herbo-mineral formulations, food articles and lifestyle along with self-discipline with social etiquette to achieve the optimum state of tissues that there is least effect of etiological factors on body. A careful analysis of qualities of Aachar Rasayana reveals that most of them are related to Mana, Dhi, Dhriti, along with good conduct. It inculcates the discipline related to mind, character, social, religious and personal life, so as to accord with the happiness and good of the individual and the society as a whole.

Two Cases Orthostatic Dysregulation in which the Effectiveness of Ryokeijutsukanto was Confirmed by Multiple Clinical Indicators / 日本東洋医学雑誌

Ryokeijutsukanto is an herbal medicinal product that is often used for dizziness when standing up, that is, orthostatic dysregulation. This time, we encountered 2 patients with orthostatic dysregulation successfully treated with ryokeijutsukanto, and objectively evaluated the therapeutic effect of ryokeijutsukanto by using Visual Analog Scale (VAS), Vertigo Symptom Scale-short form (VSS-sf) Japanese version and Dizziness Handicap Inventory (DHI) Japanese version. Case 1 is a 17-year-old woman. Dizziness when standing up appeared from 2 month ago. Before treatment, VAS scored 71/100, VSS-sf scored 7 points, and DHI scored 42 points. After 4 weeks of administration of Ryokeijutsukanto, VAS improved to 22/100, VSS-sf improved to 6 points, and DHI improved to 26 points. Case 2 is a 38-year-old woman. Dizziness when standing up appeared from 3 month ago. Before treatment, VAS scored 48/100, VSS-sf scored 18 points, and DHI scored 32 points. After 4 weeks of administration of Ryokeijutsukanto, VAS improved to 9/100, VSS-sf improved to 3 points, and DHI improved to 20 points. In both cases, all the evaluation scales showed sharp improvement after 4 weeks, indicating that ryokeijutsukanto was certainly effective.

Construction and Evaluation for Model of Goat Intervertebral Disc Degeneration Induced by Axial Compressive Stress / 医用生物力学

Objective To establish the model of goat intervertebral disc degeneration （IDD） induced by controllable axial compressive stress and evaluate its imaging and pathological characteristics. Methods Twenty goats were randomly divided into 4 groups (control group, 4-week pressure group, 8-week pressure group, 12-week pressure group, n=5, 40 N pressure). Disc height index (DHI) was used to evaluate the change of intervertebral disc height by X-ray, Pfirrmann classification method was used to observe the degree of intervertebral disc degeneration by magnetic resonance imaging (MRI), and histopathological observation and evaluation for intervertebral disc were conducted by HE staining and immunohistochemistry. Results DHI in control group showed no significant changes with the extension of pressure time, while DHI in the experimental group gradually decreased. There was no significant change in Pfirrmann classification in control group. In experimental group, with the extension of time, the higher the degeneration aggravated with the Pfirrmann classification increasing. In experimental group, HE staining showed that the disc nucleus pulposus decreased in volume and nucleus pulposus cells, which were gradually replaced by fibrous tissues. Immunohistochemical staining showed that type I collagen in the nucleus pulposus gradually increased, type Ⅱ collagen gradually decreased, and intervertebral disc degeneration occurred. Conclusions A certain axial compressive stress can lead to degeneration of goat lumbar intervertebral disc, and the degree of degeneration is gradually increased with the extension of time.

Efectividad de cinco sesiones de rehabilitación vestibular en mujeres mayores de 60 años con hipofunción vestibular / Effectiveness of five vestibular rehabilitation sessions in women over 60 years of age with vestibular hypofunction

RESUMEN Introducción: Los síntomas vestibulares son motivo frecuente de consulta en la atención médica, el adulto mayor y en especial el género femenino está expuesto a riesgo de caída por esta causa. Es común que el tratamiento de este grupo de pacientes sea los supresores vestibulares, y la terapia de rehabilitación vestibular (RV) se indique excepcionalmente, olvidando en ocasiones que los elementos anatomofuncionales involucrados en las disfunciones vestibulares son la integración del aparato visual, vestibular, y somatosensorial, pilares en los que se fundamenta la RV. Objetivo: El objetivo de este estudio es determinar si cinco sesiones RV son suficientes para disminuir la discapacidad funcional y el riesgo de caída en un grupo de pacientes con patología vestibular. Material y método: Estudio prospectivo con 14 pacientes de género femenino mayores de 61 años con diagnóstico de patología vestibular periférica. Se realizó evaluación de (dizziness handicap inventory) DHI, (timed up and go) TUG y (video head impulse test) vHIT previo y posterior a la intervención de cinco sesiones de RV. Resultados: Las tres variables estudiadas (DHI, TUG y vHIT) demostraron mejorías estadísticamente significativas en el grupo de pacientes. Conclusión: Los resultados obtenidos en este estudio permiten sugerir que la terapia de RV en pacientes adultos mayores, con patología vestibular periférica y sin medicación de supresores vestibulares, es una modalidad terapéutica adecuada y eficiente.

ABSTRACT Introduction: Vestibular symptoms are frequent reason for consultation in medical care, the elderly and especially the female gender is exposed to fall risk from this cause. It is common for the treatment of this group of patients to be vestibular suppressors while vestibular rehabilitation therapy is indicated exceptionally, sometimes forgetting that the anatomic and functional elements involved in vestibular dysfunctions are the integration of the visual, vestibular, and somatosensory, pillars in those that are based on vestibular rehabilitation (VR). Aim: The objective of this study is to determine if five VR sessions are sufficient to provide concrete quantitative data on the decrease of disability and risk of falling in a group of patients with vestibular pathology. Material and method: This prospective study included 14 female patients over 61 years of age with diagnoses of peripheral vestibular pathology. Dizziness handicap inventory (DHI), timed up and go (TUG) and video head impulse test (vHIT) were performed and after the intervention of five sessions of vestibular rehabilitation. Results: The three variables studied (DHI, TUG and vHIT) showed statistically significant improvements in the group of patients. Conclusions: The results obtained in this study allow us to suggest that VR therapy in elderly patients with peripheral vestibular pathology and without vestibular suppressor medication is an adequate, efficient and promising therapeutic modality.

Health-related quality of life and disability in patients with acute unilateral peripheral vestibular disorders / Qualidade de vida relacionada à saúde e incapacidade em pacientes com distúrbios vestibulares periféricos unilaterais agudos

Abstract Introduction: Health-related quality of life is used to denote that portion of the quality of life that is influenced by the person's health. Objectives: To compare the health-related quality of life of individuals with vestibular disorders of peripheral origin by analyzing functional, emotional and physical disabilities before and after vestibular treatment. Methods: A prospective, non randomized case-controlled study was conduced in the ENT Department, between January 2015 and December 2015. All patients were submitted to customize a 36 item of health survey on quality of life, short form 36 health survey questionnaire (SF-36) and the Dizziness Handicap Inventory for assessing the disability. Individuals were diagnosed with acute unilateral vestibular peripheral disorders classified in 5 groups: vestibular neuritis, Ménière Disease, Benign Paroxysmal Positional Vertigo, cochlear-vestibular dysfunction (other than Ménière Disease), or other type of acute peripheral vertigo (as vestibular migraine). Results: There was a statistical significant difference for each parameter of Dizziness Handicap Inventory score (the emotional, functional and physical) between the baseline and one month both in men and women, but with any statistical significant difference between 7 days and 14 days. It was found a statistical significant difference for all eight parameters of SF-36 score between the baseline and one month later both in men and women; the exception was the men mental health perception. The correlation between the Dizziness Handicap Inventory and the SF-36 scores according to diagnostics type pointed out that the Spearman's correlation coefficient was moderate correlated with the total scores of these instruments. Conclusion: The Dizziness Handicap Inventory and the SF-36 are useful, proved practical and valid instruments for assessing the impact of dizziness on the quality of life of patients with unilateral peripheral vestibular disorders.

Resumo Introdução: Qualidade de vida relacionada à saúde é usada para designar a parte da qualidade de vida que é influenciada pela saúde do indivíduo. Objetivos: Comparar a qualidade de vida relacionada à saúde de indivíduos com distúrbios vestibulares de origem periférica, analisar incapacidades funcionais, emocionais e físicas antes e após o tratamento vestibular. Método: Um estudo de caso-controle prospectivo, não randomizado, foi conduzido no Departamento de Otorrinolaringologia, entre janeiro de 2015 e dezembro de 2015. Todos os pacientes foram submetidos a uma pesquisa de saúde personalizada de 36 itens sobre qualidade de vida, ao formulário abreviado de avaliação de saúde 36 (SF-36) e ao Dizziness Handicap Inventory para avaliar a incapacidade. Os indivíduos foram diagnosticados com distúrbios vestibulares periféricos unilaterais agudos, classificados em cinco grupos: neurite vestibular, doença de Ménière, vertigem posicional paroxística benigna, disfunção cócleo-vestibular (exceto Doença de Ménière) ou outro tipo de vertigem periférica aguda (como enxaqueca vestibular). Resultados: Houve uma diferença estatisticamente significante para cada parâmetro de escore no Dizziness Handicap Inventory (emocional, funcional e físico) entre a avaliação basal e depois de um mês, tanto em homens quanto em mulheres, mas sem diferença estatística significativa entre sete dias e 14 dias. Foi encontrada uma diferença estatisticamente significante para todos os oito parâmetros do escore no SF-36 entre a avaliação basal e um mês mais tarde, tanto em homens quanto em mulheres; a exceção foi a percepção de saúde mental nos homens. A correlação entre Dizziness Handicap Inventory e o SF-36 de acordo com o tipo de diagnóstico mostrou que o coeficiente de correlação de Spearman foi moderado quando correlacionado com o escore total desses instrumentos. Conclusão: O Dizziness Handicap Inventory e o SF-36 demonstraram ser instrumentos úteis, práticos e válidos para avaliar o impacto da tontura na qualidade de vida de pacientes com distúrbios vestibulares periféricos unilaterais.

Impacto de las Maniobras de Reposicionamiento en el grado de discapacidad de pacientes con Vértigo Posicional Paroxístico Benigno del conducto semicircular posterior

Introducción. El Vértigo Posicional Paroxístico Benigno (VPPB) del canal semicircular posterior es una enfermedad crónica que afecta severamente la calidad de vida de los pacientes que lo sufren. Para su manejo existen las Maniobras de Reposicionamiento, que son una serie de ejercicios secuenciales de la cabeza en 4 posiciones. El propósito de la maniobra es reposicionar los otolitos desde el conducto semicircular posterior dentro del vestíbulo a los sitios de donde migraron para dejar de producir vértigo. Permaneciendo en cada posición aproximadamente 30 segundos. Las maniobras han demostrado gran eficacia a corto plazo. Los resultados son medibles por medio de un cuestionario conocido como Dizziness Handicap Inventory (DHI). Objetivos: Medir el impacto de las maniobras de reposicionamiento en la discapacidad en los pacientes con Vértigo Posicional Paroxístico Benigno del conducto semicircular posterior, mediante el uso del DHI. Metodología. Es un estudio comparativo que utiliza la T de Student para muestras pareadas donde cada paciente es su propio control, se tomó una muestra de 20 pacientes diagnosticados con Vértigo Posicional Paroxístico Benigno del conducto semicircular posterior que serán tratados con maniobras de reposicionamiento, serán evaluados mediante la herramienta (DHI) que será completada por los pacientes al inicio del estudio, al día 7 y día 30, luego de realizadas las Maniobras de Reposicionamiento. Resultados: Las mujeres son las más afectadas por el (VPPB) del canal semicircular posterior en una relación de 2.1 aproximadamente. El grado de discapacidad fue medido por el resultado del DHI, el cual muestra para los días 1, 7, y 30 una media de 50.4, 30.4 y 24.2 respectivamente. La escala con mayor punteo durante los días 1, 7, y 30 fue la escala funcional mostrando una media de 20, 12.2, y 9.5 respectivamente. Las diferencias entre las medias fueron estadísticamente significativas. (p= 0.00006, 0.000002 y 0.03701). Conclusiones: El padecimiento de VPPB del conducto semicircular posterior afecta la calidad en el estilo de vida de las personas. Las maniobras de reposicionamiento son estadísticamente significativas para disminuir la incapacidad generada por el vértigo posicional paroxístico benigno del conducto semicircular posterior por lo que es importante acudir rápidamente al médico especialista cuando se manifiesten los primeros signos y evitar así aumentar la discapacidad total asociada al vértigo. Palabras Clave: Vértigo Posicional Paroxístico (VPPB), otolitos, Dizziness Handycap Inventory (DHI).

Introduction. Benign Paroxysmal Positional Vertigo (BPPV) of the posterior semicircular canal is a chronic disease severely affecting quality of life. Repositioning Maneuvers is a way of relieving it, consisting of a series of sequential exercises of the head into 4 positions. The purpose of the maneuver is to reposition the otoliths from the posterior semicircular canal inside the lobby to the sites where they migrated to stop producing vertigo. Each position has to remain for approximately 30 seconds. The maneuvers have proven to be highly effective in the short term. The results are measurable by means of a questionnaire known as Dizziness Handicap Inventory (DHI). Objectives: To measure the impact of repositioning maneuvers on disability in patients with BPPV of posterior semicircular canal, using the DHI. Methods: A comparative study using T-test for paired samples where each patient is his own control was used in a sample of 20 patients diagnosed with BPPV of posterior semicircular canal were studied and treated with repositioning maneuvers. Results were evaluated by DHI and ran in day 1, day 7 and 30 after Repositioning maneuvers performed. Results: Females are most affected by BPPV in a ratio of approximately 2.1. The degree of disability was measured by the result of DHI, which shows for days 1, 7, and 30 an average of 50.4, 30.4 and 24.2 respectively. The scale with a higher score were days 1 and 7 then showing a marked decreased on day 30. Mean results were the 20, 12.2 and 9.5 respectively. The differences between the means were statistically significant. (P = 0.000062, 0.000002 and 0.037010). Conclusions: BPPV affects the quality of life. Repositioning maneuvers are statistically significant to reduce the disability caused by BPPV of the posterior semicircular canal so, it is important to quickly see a specialist when first signs manifest and that way avoid increasing the total disability associated with vertigo. Keywords: Paroxysmal Positional Vertigo (BPPV), Otolith, Dizziness Handicap Inventory (DHI)

Danhong Injection inhibits high glucose-induced injury in rat peritoneal mesothelial cells / 中成药

AIM To investigate that Danhong Injection may decrease inflammation and oxidative stress response in rat peritoneal mesothelial cells (RPMCs) cultured with high glucose.METHODS The third passage of RPMCs were used for the experiment.After being incubated with DMEM for 24 hours,RPMCs were divided into normal control group,high glucose group (RPMCs were incubate with 100 mmol/L glucose for 12 h,24 h,48 h,72 h),Danhong Injection group (complete medium with 80 mL/L Danhong Injection for 48 h) and high glucose + Danhong Injection group (100 mmol/L high glucose with 40 mL/L,80 mL/L,160 mL/L Danhong Injection for 48 h respectively).The cell proliferation was detected by MTT method.The levels of interleukin-18 (IL-18),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in culture fluid were determined by enzyme linked immunosorbent assay.The contents of malondialdehyde (MDA),superoxide dismutase (SOD),glutathione (GSH),in the culture fluid and intracellular reactive oxygen species (ROS) were measured by kits.The expressions of Bcl-2,Bax,fibronectin (FN),endothelin-1 (EDN1) and haem oxygenase-1 (HMOX1) mRNA were detected by quantitative real-time PCR.The protein expressions of EDN1 and HMOX1 were measured by Western blot.RESULTS High glucose can significantly inhibit RPMCs' viability.High glucose can also up-regulate the expressions of IL-18,IL-6,TNF-α,ROS,MDA,Bax mRNA,FN mRNA,EDN1 mRNA and down-regulate the levels of SOD,GSH,Bcl-2 mRNA,HMOX1 mRNA in RPMCs.Treatment with Danhong Injection can effectively reverse aforementioned effect induced by high glucose.CONCLUSION Danhong Injection can reverse the inhibition of cell viability,the inflammation and oxidative stress response induced by high glucose in RPMCs,thus protect peritoneal membrane.

To Know The Effectiveness Of Experimental Protocol Vs Brandt Daroff Exercises On Dizziness In Benign Paroxysomal Positional Vertigo.

Background and Aim: Benign paroxysmal positional vertigo (BPPV)1 is considered the most common peripheral vestibular disorder, affecting 64 of every 100,000 Americans. Women are more often affected and symptoms typically appear in the fourth and fifth decades of life. In 1980, Epley proposed that free-floating densities (canaliths) located in the semicircular canals deflect the cupula creating the sensation of vertigo. This is well documented in his Canalithiasis Theory4,5. Although these canaliths are most commonly located in the posterior semicircular canal, the lateral and superior canal may also be involved Patients with BPPV complain of vertigo with change in head position, rolling over, or getting out of bed, and the vertigo is often side specific. Aim of the study is to know persons with vestibular disorders experience symptoms of dizziness and balance dysfunction, resulting in falls, as well as impairments of daily life. Various interventions provided by physical therapists have been shown to decrease dizziness and improve postural control. In the present review, we will focus on the role of physical therapy in the management of BPPV symptoms of dizziness. Methodology: In the procedure Firstly ,patients will divided into two groups Group A and Group B and all the patient were assessed the pretreatment score and post treatment i.e (0 Weeks and 3 week and 6 weeks) by using the DHI ,The Patients will be randomly allocated Group A Patients was receive exercise protocol, Group B Was given the Brandt daroff exercise .this exercises were given on daily basis .After completion of 6 weeks of the treatment ,Both Group A and Group B were compared Statistical software: statistical software namely SPSS 15.0. Results and Conclusion: The study concluded that designed exercise protocol is effective to reducing dizziness in BPPV patients by measuring the DHI Scale.

The Application of DHI Scale to Evaluation of Quality of Life in Patients with Benign Paroxysmal Positional Vertigo / 听力学及言语疾病杂志

Objective This paper attempts to explore the application of dizziness handicap inventory (DHI) in evaluation of health -related quality of life (QOL ) changes of patients with benign paroxysmal positional vertigo (BPPV) before and after the treatment with canalith repositioning procedure (CRP) .Methods The DHI was em-ployed to investigate and evaluate the dizziness handicap of 120 patients with BPPV before and after 3 months of CRP treatment (treatment group) and 60 healthy controls (control group) ,while the DHI scoring results were com-pared .Results As indicated by DHI evaluation ,the scoring of each DHI items of patients with BPPV before treatment was higher than that of control group ,treatment group before treatment :functional score 22 .60 ± 6 .54 ,emotional score 18 .50 ± 8 .28 ,physical score 17 .90 ± 5 .05 ,total composite score 59 .00 ± 14 .32 .For the control group:functional score 1 .35 ± 1 .74 ,emotional score 1 .00 ± 1 .01 ,physical score 1 .37 ± 1 .86 ,total composite score 3 .72 ± 3 .46 ,with the differ-ence statistically significant (P0 .05) .Conclusion CRP is effective to treat BPPV .The DHI is available for the evaluation of QOL of BPPV patients .

Efeito da reabilitação vestibular em idosos: quanto ao equilíbrio, qualidade de vida e percepção / Effect of vestibular rehabilitation in elder people: regarding balance, quality of life and perception

As atuais preocupações com qualidade de vida (QV), envelhecimento da população, limitações impostas pelos distúrbios do equilíbrio na população idosa e a alternativa de tratamento por meio da reabilitação vestibular (RV) justificaram este estudo. Nele, objetivou-se analisar, perspectivamente, os resultados da aplicação do protocolo de Cawtome & Cooksey para RV, em idosos institucionalizados, com queixas de alterações de equilíbrio e probabilidade de queda (PQ), visando à melhoria da QV e à percepção desses idosos sobre as limitações impostas pelos distúrbios do equilíbrio. Utilizou-se uma metodologia híbrida, buscando a integração de dados quantitativos e qualitativos, associando-se o estudo experimental ao fenomenológico, em uma população de trinta idosos asilados com queixas de alterações do equilíbrio. Os instrumentos de avaliação foram a Escala de Berg, Dizziness Handicap Inventory (DHI) e análise de conteúdo. Como conclusão do estudo, constatou-se que, na população estudada, a RV foi efetiva quanto à melhora dos sintomas de alteração do equilíbrio em relação à QV, à PQ e aos sentimentos de segurança e independência dos idosos.

The current concerns with quality of life, population aging, limitations imposed by balance disturbance in the elder population and the alternative treatment through the vestibular rehabilitation had justified this study. The objective was to analyze in perspective the application of the Cawtome & Cooksey protocol for vestibular rehabilitation results in aged institutionalized people with complains of balance alterations and probability of fall, aiming the improvement of quality of life and that elders could perceive the limitations imposed by the balance disturbance. A hybrid methodology was used, searching an integration of quantitative and qualitative data associating the experimental to the phenomenological in a population of 30 elders with complains of balance alterations living in an asylum. The evaluation instruments had been the Berg Scale, Dizziness Handicap Inventory (DHI) and speech analysis. As conclusion, it was evidenced that, within the population studied, the vestibular rehabilitation was effective regarding the improvement of symptoms of balance alteration in relation to quality of life, probability of fall as well as the security and independence feelings of the elders.