The open-ended coaxial line method for colorectal cancer detection and depth evaluation of tumor invasion / 实用医学杂志

Objective To confirm whether the open-ended coaxial line is effective in detection of the differences in dielectric properties between colorectal cancer tissues and surrounding normal tissues and evaluation of the depth of tumor invasion. Methods The open-ended coaxial line system at frequencies ranging from 50 to 500 MHz in 98 freshly excised colorectal cancerous specimens obtained from the operating theatre of Zhujiang Hospital, was used to detect both the relative permittivity and conductivity on the serosal surface of the carcinoma nidus, the mucosa of the carcinoma nidus, and the mucosa of the surgical resection margin. Pathological examinations were conducted on each specimen after surgery. Results The values for relative permittivity and conductivity of the colorectal cancerous mucosa were significantly higher than those of the normal mucosa (P < 0.01). For the tumor which had invaded or penetrated the serosa (stage ≥ T3), the dielectric properties of both the cancerous serosa and mucosa were higher than the one restricted to muscularis propria or less intestine wall (stage < T3) over the measured frequency range, and there existed statistical differences at the common frequencies of 213 MHz and 426 MHz. Conclusion The open-ended coaxial line system may result in fast and effective diagnostic differentiation between cancerous and normal colorectal tissues as well as reasonable assessment of the tumor infiltration depth.

The Survival Rate of Gallbladder Carcinoma Based on the presence of Lymph Node Metastasis and the Depth of the Primary Tumor Invasion

PURPOSE: Carcinoma of the gallbladder is an aggressive, late-symptomatic disease and most patients are treated at an advanced stage, and these patients have a poor prognosis. During recent years, extended operations that combine a resection of the liver with wide lymph node dissection have improved the long-term survival. The aim of this study is to evaluate the surgical outcome for gallbladder carcinoma based on the presence of lymph node metastasis and the depth of the primary tumor invasion. METHODS: A retrospective analysis was done on 68 patients who underwent a surgical resection of gallbladder carcinoma from 1997 to 2004. The factors that nfluenced the 5-year survival were examined. RESULTS: The overall 5-year survival rate was 49.6%. The lymph node metastasis rate was 40.0% in T2 disease and 61.1% in T3/T4 disease. The 5-year survival rate (5-YSR) for T2 disease was 52.1% for the patients who underwent cholecystectomy with lymph node dissection and hepatic resection, and it was 51.2% for the patients who underwent only simple cholecystectomy. The 5-YSR for T3/T4 disease was 33.3% for the patients who underwent extended cholecystectomy, and it was 12.9% for the palliative cholecystectomy patients. CONCLUSION: The role of radical surgery seems to be limited for patients with more extensive tumor invasion or lymph node metastasis.