RESUMO
Objective To study the effect of dexmetomidine on postoperative analgesia in patients with colon cancer after minimally invasive surgery. Methods From January 2015 to March 2018,78 patients with colon cancer treated in Shanxi Coal Central Hospital were randomly divided into the observation group and the control group,with 39 cases in each group. The control group was treated with fentanyl, and the observation group was treated with dexmedetomidine for analgesia. The analgesic effect and adverse reaction were observed and compared between the two groups. Results At 6 h,12 h,24 h,48 h after operation,the resting pain VAS scores in the observation group [(2.2 ±0.8)points,(2.4 ±0.5)points,(2.1 ±0.5)points,(1.8 ±0.5)points]were significantly lower than those in the control group[(3. 4 ± 0. 9)points,(3. 7 ± 0. 8)points,(3. 2 ± 0. 6)points,(2. 7 ± 0. 5)points],the differences were statistically significant (t=2. 241,2. 839,2. 580,2. 683,P=0. 036,0. 004,0. 010,0. 007). At 6 h,12 h,24 h after operation,the VAS scores of active pain in the observation group[(1. 3 ± 0. 6) points,(1. 5 ± 0. 5) points, (1. 1 ± 0. 4)points] were significantly lower than those of the control group[(1. 7 ± 0. 5)points,(2. 1 ± 0. 7)points, (1.7 ±0.6)points](t =2. 521,2. 753,2. 683,P =0. 015,0. 006,0. 007). The incidence rate of nausea of the observation group was 5. 1% ,which was significantly lower than 33. 3% of the control group. There were no patients with vomiting and high blood pressure. The incidence rates of nausea and vomiting of the observation group were lower than those of the control group,the differences were statistically significant (χ2=4. 841,4. 713,P=0. 022,0. 031). Conclusion Dexmetomidine has significant analgesic effect on patients with colon cancer after minimally invasive surgery. It is safe and has no obvious adverse reaction.
RESUMO
Objective To study the effect of dexmetomidine on tracheal intubation under abdominal anesthesia.Methods From January 2015 to January 2018,100 patients were selected to perform tracheal intubation under abdominal anesthesia in Shanxi Provincial Hospital of Taiyuan.A total of 100 patients under abdominal surgery were randomly divided into two groups,with 50 patients in each group.The observation group was given dexmetomidine intravenous injection during the operation,while the control group was not given dexmetomidine during the operation.The blood pressure and heart rate of the two groups were compared before and after anesthesia.The recovery time of spontaneous respiration,eye opening time,extubation time,incidence of adverse events,cough score and restlessness score were compared between the two groups,and the cognitive function of the two groups was compared.Results After anesthesia,the systolic blood pressure [(103.75 ± 2.26) mmHg],diastolic blood pressure [(71.92 ± 1.95) mmHg],heart rate[(70.91 ± 1.89) rpm] in the observation group were significantly higher than those in the control group [(100.37 ±2.91)mmHg,(70.27 ± 1.84)mmHg,(69.08 ±1.63)] (t =6.487,4.532,5.185,all P ＜0.05).The recovery time of spontaneous respiration [(7.14 ± 1.37) min],eye opening time [(9.85 ± 2.31) min] and extubation time[(20.57 ±2.94)min]in the observation group were significantly shorter than those in the control group[(8.75 ± 1.89)min,(12.41 ±2.97)min,(24.06 ±3.42)min] (t =4.877,4.811,5.472,all P ＜0.05).The incidence rate of adverse events in the observation group (8％) was lower than 24％ in the control group (x2 =4.762,P ＜ 0.05).The score of cough and the score of restlessness in the observation group were (4.09 ± 1.63) and (4.27 ± 1.96),respectively,which were significantly lower than those in the control group [(6.24 ± 2.18) and (6.51 ± 2.32)] (t =5.186,5.215,all P ＜ 0.05).At 6 h after operation,the scores of MMSE,vocabulary memory,simple calculation and picture memory in the observation group were (23.95 ±2.13),(7.35 ± 1.08),(7.14 ± 1.12) and (7.26 ± 1.17),respectively,which were higher than those in the control group[(20.47 ± 1.91),(6.17 ± 0.94),(5.89 ± 1.04),(6.02 ± 0.89)] (t =8.601,5.828,5.783,5.965,all P ＜ 0.05).Conclusion The application of dexmetomidine in patients under general anesthesia under tracheal intubation can effectively reduce the fluctuation of hemodynamic indicators after anesthesia,help to maintain the hemodynamic stability of patients,and promote the recovery of consciousness after operation.It can prevent adverse events during recovery of anesthesia and reduce the effect of anesthesia on cognitive function of patients.