Repercussions of the Emergency neurological life support on scientific literature: a bibliometric study / Repercussões do Emergency neurological life support na literatura científica: um estudo bibliométrico

Abstract Background In 2012, the Neurocritical Care Society launched a compilation of protocols regarding the core issues that should be addressed within the first hours of neurological emergencies - the Emergency neurological life support (ENLS). Objective We aim to evaluate this repercussion through a bibliometric analysis. Methods We searched Scopus on October 2022 for articles mentioning ENLS. The following variables were obtained: number of citations; number of citations per year; number of publications per year; year of publication; research type; research subtype; country of corresponding author and its income category and world region; journal of publication and its 5-year impact factor (IF); and section where ENLS appeared. Results After applying eligibility criteria, we retrieved 421 articles, published from 2012 to 2022. The mean number of citations per article was 17.46 (95% Confidence Interval (CI) = 8.20-26.72), while the mean number of citations per year per article was 4.05 (95% CI = 2.50-5.61). The mean destiny journal 5-year IF was 5.141 (95% CI = 4.189-6.093). The majority of articles were secondary research (57.48%; n= 242/421) of which most were narrative reviews (71.90%; n= 174/242). High-Income countries were the most prominent (80.05%; n= 337/421 articles). There were no papers from low-income countries. There were no trials or systematic reviews from middle-income countries. Conclusion Although still low, the number of publications mentioning ENLS is increasing. Articles were mainly published in journals of intensive care medicine, neurology, neurosurgery, and emergency medicine. Most articles were published by authors from high-income countries. The majority of papers were secondary research, with narrative review as the most frequent subtype.

Resumo Antecedentes Em 2012, a Neurocritical Care Society lançou uma compilação de protocolos sobre as questões centrais que devem ser abordadas nas primeiras horas de emergências neurológicas - Emergency neurological life support (ENLS). Objetivo Avaliar a repercussão do ENLS por meio de uma análise bibliométrica. Métodos A base de dados Scopus foi utilizada em outubro de 2022 para a busca por artigos mencionando o ENLS. As seguintes variáveis foram obtidas: número de citações; número de citações por ano; número de publicações por ano; ano de publicação; tipo de pesquisa; país do autor correspondente e sua categoria de renda; revista de publicação e seu fator de impacto de 5 anos (IF); e seção onde o ENLS apareceu. Resultados Os 421 artigos incluídos foram publicados de 2012 a 2022. A média de citações por artigo foi de 17.46 (intervalo de confiança (IC) 95% = 8.20-26.72), enquanto a de citações por ano por artigo foi de 4.05 (IC95% = 2.50-5.61). O IF médio por revista foi de 5.14 (IC95% = 4.19-6.09). A maioria dos artigos era de pesquisa secundária (57.48%; n= 242/421), dos quais a maioria eram revisões narrativas (71.90%; n= 174/242). Os países de alta renda foram os mais prolíficos (80.05%; n= 337/421 artigos). Não houve publicações de países de baixa ou média renda. Conclusão Embora ainda baixo, o número de publicações mencionando o ENLS vem aumentando recentemente. A maioria dos artigos foram publicados em revistas de medicina intensiva, neurologia, neurocirurgia e medicina de emergência. Artigos de pesquisa secundária foram os mais comuns, com revisões narrativas sendo o subtipo mais frequente.

Diagnostic and Therapeutic Strategy Updates of Rare Oncogenic Mutations in Chinese Society of Clinical Oncology Guidelines on Diagnosis and Treatment of Non-small Cell Lung Cancer (2023 Edition) / 肿瘤防治研究

The Chinese Society of Clinical Oncology (CSCO) issued the new version of the guidelines on diagnosis and treatment of NSCLC in April 2023.The new version updated the diagnostic and therapeutic strategy of rare oncogenic mutations, including ROS1 fusion, BRAF V600E mutation, NTRK fusion, MET exon 14 skipping mutation, RET fusion, and EGFR exon 20 insertion mutation, in NSCLC.This review will interpret the most important updates in the guidelines 2023 regarding the diagnosis as well as first-line and post-line therapies of these rare oncogenic mutations.

Cardiovascular surgery in COVID-19: Change and countermeasure / 中国胸心血管外科临床杂志

@#The coronavirus disease 2019 (COVID-19) epidemic has a tremendous impact on the countries around the world since the outbreak in December 2019. From December 2022, with the loosening of domestic epidemic control policies, the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rose significantly and reached to its epidemic peak in the majority of the cities in China, which further overwhelmed our medical care system. The cardiac surgery departments in China lack the experience in conducting work under the COVID-19 pandemic. In this paper, we summarize the main topics that might be faced during the pandemic by reviewing the previous related literatures, which included: the cardiac surgery volume trends, the impact of SARS-CoV-2 infection on the prognosis of cardiac surgery, the timing of cardiac surgery and the surgical strategy should be modified, and possible recommendations for the manager or governors during the pandemic, so as to outline a path forward for cardiac surgery for the near future.

Progress of the functions and active mechanisms of sepsis associated microRNAs and their diagnostic value / 中华检验医学杂志

Sepsis is a syndrome encompassing a uncertain pathobiology and threatens the health of human being. The new definition of sepsis indicates that sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The exacerbation of inflammation accompanied with dysregulation of immunosuppression leads to the complicated changes of pathophysiology in sepsis. MicroRNAs (miRNAs) perform vital roles in the regulations of inflammation responses as well as organ damages associated with sepsis. The variety in the expression level of miRNA appears in the development of sepsis; monitoring and analyzing miRNA levels contributes to the diagnosis and prognosis of the disease. Controlling the expression levels of miRNAs related with sepsis is able to alleviate the organ damages and dysfunctions caused by the disease.

Progress of the functions and active mechanisms of sepsis associated microRNAs and their diagnostic value / 中华检验医学杂志

Sepsis is a syndrome encompassing a uncertain pathobiology and threatens the health of human being. The new definition of sepsis indicates that sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The exacerbation of inflammation accompanied with dysregulation of immunosuppression leads to the complicated changes of pathophysiology in sepsis. MicroRNAs (miRNAs) perform vital roles in the regulations of inflammation responses as well as organ damages associated with sepsis. The variety in the expression level of miRNA appears in the development of sepsis; monitoring and analyzing miRNA levels contributes to the diagnosis and prognosis of the disease. Controlling the expression levels of miRNAs related with sepsis is able to alleviate the organ damages and dysfunctions caused by the disease.

IgG4 related disease involving the renal pelvis: a case report and the literature review / 中华泌尿外科杂志

Objective To summarize the characteristics of IgG4 related disease (IgG4-RD),and to avoid unnecessary surgical procedures due to misdiagnosis.Methods Retrospective analysis of the clinical data of one case of IgG4 related disease involving the renal pelvis in our hospital,and the clinical features of IgG4 related disease involving the renal pelvis were reviewed and discussed.A 56-year-old man presented with microscopic hematuria,CT showed right renal pelvis and ureteral wall thickening,local soft tissue density,post contrast CT showed low-density renal pelvic mass and the wall of the ureter-pelvic was irregularly thicken,indicating renal pelvic cancer and lymph node metastasis.PET-CT (18F-FDG) findings indicated that the renal pelvic mass was a malignant tumor,because the glucose metabolism was very high.The preoperative diagnosis was retroperitoneal lesion,suspecting renal pelvic carcinoma or lymphoma.The patient underwent 3D laparoscopic nephroureterectomy with out preoperative biopsy.During operation,we found extensive enlargement of the right renal portal and retroperitoneal lymph nodes,including that the renal portal and the renal pelvis mass had a serious adhesion to the vena cava and renal arterial vein.Results Postoperative pathology results revealed lymphatic tissue hyperplasia and germinal center formation.Immunohistochemical staining showed that most plasma cells positive expression of IgG4 (IgG4 ＞ 40％,IgG4 ＞ 100/HPF),reactive hyperplasia of lymph node,considering the IgG4 related diseases.Serum IgG4 level was 15.2 g/L (0.03-2.01 g/L)after operation.Combined with serological examination,IgG4 related disease was confirmed.There was no evidence of IgG4-related disease at any other site during the follow up period,thereby obviating the need for any additional therapy.Conclusions IgG4 related disease is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells,which leads to the enlargement of the organ or nodular/proliferative lesions.The disease can be revealed as a soft tissue tumor of the renal pelvis and be misdiagnosed as malignant tumor.Surgical intervention could be avoided according to the correct diagnosis.

Research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy / 国际生物医学工程杂志

Chemotherapy is one of the traditional tumors treatment solutions.Chemotherapy has the feature of tissue non-specificity,which can cause side effects on normal cells while inhibiting tumor cell growth.Magnetic targeting drug delivery system (MTDDS) employs biocompatible and stable magnetic nanoparticles (MNP) as drug carries to transport and accumulate anticancer drugs to the specific tumor tissues under the guidance of external magnetic field.This technology not only improves the efficiency of drug delivery and antitumor activity,but also reduces the drug dosage and side effects.The properties of drug-loaded MNPs and the applied external magnetic field are the main factors that affecting the MNPs targeting to the tumor tissues.The effectiveness of the targeted delivery of the drug-loaded magnetic nanoparticles mainly depends on the form and strength of the magnetic field at the target site.That is,whether there is sufficient strength to attract and retain NMPs,and to promote antitumor drug release at the tumor region.In this paper,the research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy was summarized,which can provide some basic information for the relative scientific researches.

Intervenciones de enfermería para la detección oportuna, el control y limitación del daño por diabetes mellitus tipo 1 y tipo 2 en la población mayor de 12 años / Nursing interventions for early detection, control and limitation of damage Diabetes Mellitus Type 1 and Type 2, the population over 12 years

Introducción: En México la diabetes mellitus, se encuentra entre las primeras causas de muerte, ocupa el séptimo lugar a escala mundial. 6.4 millones de personas refirieron haber sido diagnosticadas con diabetes. La cifra de diagnóstico previo aumenta después de los 50 años representando un gasto de 3,430 millones de dólares al año en atención y complicaciones. Métodos: Planteamiento de preguntas a responder y conversión a preguntas clínicas estructuradas, búsqueda y revisión sistemática de literatura: recuperación de guías internacionales, meta-análisis, ensayos clínicos aleatorizados y estudios observacionales. Se estableció un algoritmo de búsqueda reproducible en bases de datos electrónicas, encontrando 40 fuentes de utilidad. Se realizó validación por pares clínicos mediante el método Delphi y validación de protocolo de búsqueda así como evaluación de la Calidad de evidencia y fuerza de recomendación, y aprobación por el Comité Nacional de Guías de Práctica Clínica.Resultado: Se plantearon 3 preguntas estructuradas y del análisis de la literatura se obtuvieron 36 evidencias, 40 recomendaciones y 4 puntos de buena práctica lo que contribuirá a disminuir la incidencia, prevalencia, morbilidad y complicaciones de la diabetes mellitus. Conclusiones: Mejorar la efectividad, seguridad y calidad de la atención contribuye al bienestar de las personas y comunidades mediante la monitorización de los niveles de glucosa, estrategias de educación, visitas de seguimiento, asesoramiento, y un programa educativo. Diabetes Mellitus, Educación, Enfermería, Prevención y Control, Diagnóstico y Terapia

Introduction: In Mexico the diabetes mellitus, is among the leading causes of death, ranks seventh worldwide. 6.4 million people reported having been diagnosed with diabetes. The number of previous diagnosis increases after 50 years representing an expenditure of 3,430 million dollars a year in care and complications.Methods: Asking questions to answer and conversion to structured clinical questions, search and systematic review of literature retrieval international guidelines, meta-analyzes, randomized trials and observational studies. Search algorithm was established reproducible in electronic databases and collaborating centers, finding 40 sources of income. Clinical validation pairs was performed using the Delphi method and search protocol validation and evaluation of the quality of evidence and strength of recommendation, and approval by the National Committee on Clinical Practice Guidelines.Result: Three structured questions were established and from the analysis of the literature 36 evidences were raised, 40 recommendations and 4 points of good practice were obtained and will help to reduce the incidence, prevalence, morbidity and complications of diabetes mellitus.Conclusions: To improve the effectiveness, safety and quality of caring contributes to the wellbeing of people and communities by monitoring glucose levels, education strategies, follow-up visits, counseling, and an educational program. Diabetes Mellitus, Education, Nursing, Prevention and Control, Diagnosis and Therapy

As intervenções de enfermagem para detecção precoce, controle e limitação de danos causados por diabetes mellitus tipo 1 e tipo 2 na população acima de 12 anosIntrodução: No diabetes mellitus do México, está entre as principais causas de morte, é o sétimo no mundo. 6,4 milhões de pessoas relataram ter sido diagnosticado com diabetes. O número de aumentos de diagnóstico prévio após 50 anos representando uma despesa de 3.430 milhões de dólares por ano em cuidados e complicações. Métodos: Abordagem de questões clínicas para responder, pesquisar e revisão sistemática de diretrizes internacionais de recuperação de literatura, meta- análise, ensaios clínicos randomizados e estudos observacionais. algoritmo de busca foi estabelecida reprodutível em bases de dados electrónicas, encontrando 40 fontes de renda. pares de validação clínica foi realizada utilizando o método e protocolo de busca de validação Delphi e avaliação da qualidade da evidência e força de recomendação, e aprovação pelo Comitê Nacional de Diretrizes da Prática Clínica. Resultados: 3 estruturadas e análise das questões de literatura foram levantadas 36 provas, 40 recomendações e 4 pontos foram obtidas boas práticas que vão ajudar a reduzir a incidência, prevalência, morbidade e complicações da diabetes mellitus. Conclusões: promover a melhoria da eficácia, segurança e qualidade dos cuidados de contribuir para o bem-estar das pessoas e comunidades, monitorando os níveis de glicose, estratégias de ensino, visitas de acompanhamento, aconselhamento e um programa educacional. Diabetes Mellitus, Educação, Enfermagem, Prevenção e Controle, Diagnóstico e Terapia

Clinical study for stroke treated with meridian-collateral diagnosis and therapy by / 中国针灸

<p><b>OBJECTIVE</b>To compare the effect difference for stroke between meridian-collateral diagnosis and therapy byand conventional acupuncture with syndrome differentiation.</p><p><b>METHODS</b>Totally 148 patients were assigned into an observation group(72 cases) and a control group(76 cases) by random number table,with 10 cases dropping out in the observation group. In the observation group,meridians were examined and differentiated and then the treating meridians and acupoints were defined. Corresponding acupuncture was used according to them. In the control group,acupuncture was applied at acupoints by internal differentiation and experience. Treatment was given once a day and five times a week,with total 20 times. The motion function of limbs and coloboma degree of nerve function were assessed by Fugl-Meyer score and National Institutes of Health Stroke Score(NIHSS) before and after treatment as well as at three-month follow-up.</p><p><b>RESULTS</b>After treatment,the Fugl-Meyer scores increased and the NIHSS scores decreased in the two groups compared with those before treatment(all<0.05). At follow-up three months after treatment,Fugl-Meyer score upgraded in the observation group (<0.05) and NIHSS score declined in the two groups (both<0.01) than those before treatment,and NIHSS scores were statistically different between the two groups(<0.05).</p><p><b>CONCLUSIONS</b>Meridian-collateral diagnosis and therapy byhas better long-term efficacy when it is compared with conventional acupuncture with syndrome differentiation for motion function of limbs and nerve function of stroke.</p>

Abordagem do pediatra na puberdade precoce (do leite de bruxa ao Tanner V) / Role of the Pediatrician in early puberty (from witch milk to Tanner V)

O autor estuda o desenvolvimento puberal normal, define a puberdade precoce, analisa suas variações epidemiológicas, classificação e doenças envolvidas, quanto ao diagnóstico e tratamento, avaliação pelo pediatra e encaminhamento ao endocrinologista, quando necessário.

Clinical analysis of 45 patients with community acquired pneumonia complicated with type two diabetes / 中国基层医药

Objective To investigate clinical characteristics about patients of community acquired pneumonia complicated with type two diabetes and the methods of diagnosis and therapy, in order to improve recovery rate.Methods To analyze clinical data methods of diagnosis and therapy and therapeutic effect of forty five patients who were diagnozed community acquired pneumonia complicated with type two diabetes. Results The clinical characteristics of patients of community acquired pneumonia complicated with type two diabetes are delitescence of symptom,metabolic disturbance,severe pathogenetic condition,difficult control of infection and high fatality rate cetera,after afford homologue treatments including regimenting blood glucose, selecting sensitive antibiotics to control infection, ameliorating pulmonary function and nutritional support and so on, thirty eight patients were cured, two patients were given up because of severe pathogenetic conditions,five patients died because of multiple organ failure,recovery rate was 84. 44%. Conclusion Compared to patients of purecommunity acquired pneumonia, the patients of community acquired pneumonia complicated with type two diabetes had unique clinical characteristics, and need to give special treatment

Hipoglicemia infantil / Hypoglycemia of infancy

Hypoglycemia of infancy is a common metabolic disorder that can have serious neurological consequences. Therefore, its early diagnosis and treatment are crucial prognostic factors. Hypoglycemia has a variety of causes and a good clinical history, physical examination and laboratory determination will orient the correct diagnosis. Occasionally a molecular study will be required.

Clinical analysis of 212 patients suffering from benign biliary strictures / 中国综合临床

Objective To analyze the etiology,diagnosis and therapy of benign biliary strictures and im-prove curative and preventive effects. Methods 212 patients suffering from benign biliary strictures in Nankai Hos-pital from January 2004 to December 2006 were retrospectively analyzed. Results Inflammatory strictures (65.12%,140/215) and strictures caused by operations (20.46%,44/215) were the most two causes. Strictures parts were mainly located in the latter segment of common bile duct 52.09% (112/215). In our group,the stent of strictures parts took 31.37% (64/204), bilioendodraignage 18.13% (37/204), and the modification of strictures parts 43.63% (89/204) as well as resection of stricture parts 1.96% (4/204). Conclusions Inflammatory stricture is the main cause in benign biliary strictures and the main locus is the hinder segment of common bile duct. The di-agnesis of benign biliary strictures before operation is important because it can help to decide the approach way and prognosis. The strategies of curing benign biliary strictures could include operations and endoscopy. The stent of stric-tures parts, bilioendodraignage and the modification of strictures parts are the main treaments for benign biliary stric-tures.

The interventional diagnosis and therapy for thyroid disease should be studied deeply and developed prudently / 介入放射学杂志

Many details concerning the interventional diagnosis and therapy of thyroid disease need to be studied deeply and carefully; for example, the thyroid applied anatomy, especially the anatomical imageology study of the thyroid arterial anastomosis involving the therapeutic effects and complications, the thyroid artery embolization treatment, presently as a substitution or the supplement therapy for the traditional classical therapy of Graves disease. There are many exploration to extend the indication scope, the therapeutic effect, embolization scope in intervention for Graves disease due to having no accurate individual quantification standard, and so on. The thyroid arterial embolization for Graves disease is to reduce the main cause of thyroxin secretion. Simultaneously, the comprehensive therapeutic effects might have possibly produce the thyroidcytic apoptosis and immune adjustments. Serious complications such as the cerebral infarction, the hyperthyroidism crisis, the hypocalcemia, the periodic paralysis, and so on commonly occured in thyroid arterial embolization. It is necessary to keep strictly the procedure rule and the indication. The mid-and long-term therapeutic effect of thyroid artery embolization for Graves disease is good, but still need more extensive and prudent research for the prospective achievement.

Recognition of the Diagnosis and Therapy Mode of Combinating Diseases and Symptoms in Traditional Chinses Medcine / 中华中医药杂志

Different diagnosis and therapy modes decide different professional choices of clinical thought.In this artical,writer not only analyse the influence of two diagnosis and therapy modes combinatied diseases with symptoms in Traditonal Chinses Medicine clinic,discuss the actual significance of establishing the mode combinated diseases with symptoms;but also bring up the ways and manners of diagnosis and therapy modes combinated diseases with symptoms,which combine diseases of Chinese and Western medicine concents based on the diagnosis and therapy modes of Shang Han Lun.In order to support the methodology basic for building up the diagnosis and therapy modes combinated diseases with symptoms,which is able to meet the clinical thought characteristic of Traditional Chinese Medcine.

Development of multi-function hydraulic pressure diagnostic and therapeutic instrument / 医疗卫生装备

This paper introduces some information of the multi-function hydraulic pressure diagnostic and therapeutic instrument, which is applied to the diagnoses and treatments of oviduct, matrix, urethra, bladder and bile duct, including its system function, operation principle, software and hardware designs. Being reliable, cheap, convenient and multipurpose, the instrument has a bright future in the market.

Clinic investigation of pseudoaneurysm / 重庆医科大学学报

Objective:To improve diagnosis and therapy of pseudoaneurysm by retrospectively discussing and analyzing of patients with pseudoaneurysm.Methods:The curative effects in 30 patients with pseudoaneurysm from 2003 to 2006 treated in our department were retrospectively addictive drugs and iatrogenic false.Femoral artery were constantly injuryed position.30 clinical cases were treated by surgical operations.The surgical treatment methods included pseudoaneurysm resection and arterial ligation in 9 cases,arterial suture in 3 cases,pseudoaneurysm resection and arterial suture in 15 cases,pseudoaneurysm resection and artificial vascular or autogenous saphenous vein bypass grafting in 3 cases.Conclusion:Pseudoaneurysm could be successfully cured after accurate diagnosis and proper surgical therapy.