Progress of intestinal flora in colorectal cancer / 肿瘤研究与临床

The pathogenesis of colorectal cancer is related to genetic and environmental factors. Chronic inflammation of the intestinal mucosa is one of the most important factors in environmental factors. In inflammation factors, Intestinal flora plays a role in bridging and inducing intervention. Environmental changes disrupt the homeostasis of intestinal flora, intestinal flora maladjustment occurred, bacteria induces intestinal mucosal inflammation. The pathogenic bacterium adheres to the surface of the intestinal mucosa, it produces cytotoxic and genotoxic products, intestinal epithelial cells undergo genetic damage. The synthesis and metabolites of bacteria also control the occurrence of colorectal tumor process. This process leads to the progression of inflammation to cancer. This article reviews the process of intestinal flora mediated from inflammation to carcinogenesis, and the latest progress in related pathogenic bacteria, and proposes that the intestinal flora can be adjusted and targeted removal of the conditional pathogenic bacteria, and achieve the goal of cancer prevention. The relationship between intestinal flora, intestinal inflammation and colorectal cancer is reviewed.

Research advances in the pathogenesis of autoimmune hepatitis / 临床肝胆病杂志

Autoimmune hepatitis (AIH) is a progressive chronic inflammatory liver disease with unknown etiology. At present, genetic susceptibility and environmental factors are universally recognized as the etiological factors for AIH. With the deepening of research in recent years, other etiological factors, such as immune cells, immune factors, liver transplantation, and drugs, have attracted more and more attention. This article briefly describes related research findings in the past five years.

Investigation and analysis on hearing status of workers exposed to noise / 中国耳鼻咽喉头颈外科

OBJECTIVE To investigate the influence of noise on the hearing of the workers with noise exposureand explore the relationship between the hearing damage and the length of noise exposure.METHODS 120 workers who exposed to noise were recruited. Their physical examination including audiometry was done in our hospital from year 2012 to 2014. Hearing loss and the length of noise exposure were detected in all subjects after 2-year's follow-up.The rate of hearing loss between workers with different length of noise exposure was analyzed statistically. RESULTS There were 22 workers who were exposed to noise for 2 years, 43 workers for 3-5 years and 55 workers for 6-10 years. After 2-year's follow up, there were significant differences between the rate of hearing loss and the length of noise exposure at 3,4 and 6 kHz. And the rate of hearing loss at different sound frequency were significantly different statistically. CONCLUSION The relevance ratio of hearing loss in long noise-exposed group was significantly higher than short groups. The hearing damages at 4 KHz were more frequent than other sound frequency.

The relationship between mine environment and hypertension in coal miners / 中华内科杂志

Objective To investigate the relationship between mine environment and hypertension in miners. Methods 1736 male miners who worked under the ground and 825 on the ground were recruited in this study. Prevalence of hypertension under the ground and on the ground miners was compared. Results Prevalence of hypertension of miners under the ground was 23.91% and on the ground was 15.52% (χ2 = 23.56,P <0.001 ). Compared to miners on the ground, the relative risk of hypertension under the ground workers was 1.71 (95% CI 1.38 - 2.13 ). Prevalence of hypertension was correlated to the years of ground working (χ2 = 37.00, P < 0.001 ). The binary logistic regression showed significant relationship between mine environment and hypertension under the ground miners ( OR = 1.05,95% CI 1.02 - 1.08 ).Conclusion The underground environment is an important risk factor hypertension to the miners.

Preliminary analysis on specific expressed genes in brain tissue of rats with stroke-like episodes induced by complex environmental factors / 中华神经科杂志

Objective To investigate the stroke caused by a combination of genetic and environmental factors Though epidemiological studies have provided evidence of genetic influence on the occurrence of human stroke,however,the role of environmental risk factors to the development of stroke is still not well known. Methods Using cold stimuli plus high salt intake as environmental risk factors, we established a hypertension model in rats, for producing a complicated stroke, then, applied a new technique, suppression subtractive hybridization(SSH),to identify the differential genes which were specifically expressed in total rat cerebrum tissues in between two populations, namely the control and the stroke groups. Results Using this SSH approach, totally 288 clones were generated in our study from a subtractive libraries, among them,226 clones were usable and analyzed The average length of this group is (286 6?120 3) bp Among those clones, 126 clones represented sequences with significant identity to the known genes, 78 were matched to existing ESTs in dbEST but not to any known gene sequences, and the remaining 22 were novel transcripts exhibiting no similarity to any known sequences Mitochondrial transcripts were observed at a high rate of 26 5% Mitochondrial genes may play important roles in causes and effects of stroke. Conclusions Our investigation suggests that environmental risk factors may induce an increased sensitivity to stroke through genetic influence Also we will identify the genes responsible for stroke in this rat model